1,2,3-三甲氧基苯置于selenium(Iv) Oxide,双氧水,四氯化钛,三乙胺体系中,用 甲醇,二氯甲烷,叔丁醇 用作溶剂,化学反应 1.5H,反应生成2,3,4-三甲氧基苯酚 参考文献:Pet Imaging Of Nobiletin Based On A Practical Total Synthesis 标题:Pet Imaging Of Nobiletin Based On A Practical Total Synthesis 摘要:一种实用的合成方法成功合成了多甲氧基化的柑橘黄酮-诺比利丁,采用了我们新开发的黄酮合成法.合成的诺比利丁通过选择性去甲基化和快速引入11C原子进行了标记.正电子发射断层扫描图像成功地可视化了其在大脑中的分布,这可能为阿尔茨海默病的治疗提供治疗性益处. Doi:10.1039/c0Cc04936K
专利号:CN-102477452-A 优先权日:2010-11-22 标题:Enzymatic Synthesis of a Surfactant
专利号:WO-0149681-A1 优先权日:1999-12-30 标题 :A method for the preparation of substituted benzene derivatives 发明人:RUHLAND THOMAS; ROTTLAENDER MARIO; ANDERSEN KIM 权利人:LUNDBECK & CO AS H; RUHLAND THOMAS; ROTTLAENDER MARIO; ANDERSEN KIM 摘要:A method for the preparation of selectively substituted benzene derivatives by application of solid phase synthesis is disclosed. In particular, the invention provides a novel method for the preparation of substituted benzene derivatives containing two or three groups bound to the benzene ring via nitrogen-, oxygen-, sulphur-, selenium- or carbon-carbon bonds, by application of solid phase chemistry alone or in combination with post cleavage solution phase derivatisation.
专利号:GB-1566874-A 优先权日:1975-09-29 标题:Process for synthesis of coenzyme
专利号:GB-1566875-A 优先权日:1975-09-29 标题:Process for synthesis of coenzyme q compounds
专利号:US-5734067-A 优先权日:1994-09-28 标题 :Anti-oxidative tricyclic, condensed heterocyclic compound 发明人:JINNO SHUJI; KOGURE YASUYO; ONUKI HIROYUKI; OKITA TAKAAKI 权利人:NIPPON SUISAN KAISHA LTD 摘要:Providing a novel tricyclic, condensed heterocyclic compound having an anti-oxidative action and being promising for use in pharmaceutical agents, cosmetics, chemical products and the like. By chemical synthesis, a novel anti-oxidative, tricyclic, condensed heterocyclic compound represented by the following formula: ##STR1## (wherein X--Y represents CH 2 --Câ• O, CH 2 --CH 2 or CHâ• CH; Z represents O, S, or Sâ• O; R 1 to R 8 represent independently those selected from the group consisting of hydrogen atom, a hydroxyl group, a halogen group, a lower alkyl group, a lower alkoxyl group, a lower alkyl ketone group and CF 3 ; and at least two of R 1 to R 4 are hydroxyl groups); and the salts thereof are provided. The compound has an anti-oxidative activity at the same degree as or higher than the activity of α-tocopherol, so the compound is promising as a therapeutic drug for a variety of diseases, such as cancer, arteriosclerosis, or liver diseases, in which it is believed that biological lipid peroxides may b involved.
参考文献:10.1007/s11095-005-8813-4 摘要:Fedorov SN, Radchenko OS, Shubina LK, Balaneva NN, Bode AM, Stonik VA, Dong Z. Evaluation of Cancer-Preventive Activity and Structure–Activity Relationships of 3-Demethylubiquinone Q2, Isolated from the Ascidian Aplidium glabrum, and its Synthetic Analogs. Pharmaceutical Research. 2006 Jan;23(1):70–81. doi: 10.1007/s11095-005-8813-4.