CAS: 203854-49-3; Fmoc-ß-Hoglu(Otbu)-Oh

相似化合物

1421258-67-4 1275612-13-9 2135655-76-2

上下游产品

CAS号71989-18-9 Fm°C-O-叔丁基-L-谷氨酸

N-芴甲氧羰基-L-谷氨酸gamma-叔丁酯一水物置于n-甲基吗啉,Silver Trifluoroacetate,氯甲酸异丁酯体系中,用 四氢呋喃,水 用作溶剂,化学反应 12.33H,反应生成Fmoc-L-Beta-高谷氨酸 6-叔丁酯
参考文献:的制备ñ-Fmoc保护的β 2-和β3氨基酸和它们作为构建块的β肽固相合成中的用途†往最‡
标题:的制备ñ-Fmoc保护的β 2-和β3氨基酸和它们作为构建块的β肽固相合成中的用途†往最‡
摘要:受n-Fmoc保护的(fmoc =(9 H-氟-9-基甲氧基)羰基)β-氨基酸是在固相支持物上高效合成β-寡肽所必需的.对映体纯的fmoc-β 3-氨基酸β 3:侧链和nh 2在c(3)(= C(β))从fmoc保护的(制备小号)-和(-[r)-α-氨基酸与脂族,芳香族和官能化侧链,使用标准或优化的arndt-Eistert反应顺序.将fmoc-β 2-氨基酸(β 2在c(2),Nh侧链2(中c 3)(= C(β)))配置轴承丙氨酸,缬氨酸,亮氨酸,和phe的侧链合成经由所述埃文斯'手性助剂的方法.目标β 3个-Heptapeptides 5-8,一个β 3-十五肽9和β 2-Heptapeptide 10使用常规的固相肽合成方法(在手动固相合成装置合成方案3).在β的情况下3-肽,两种方法被用于锚定所述第一β氨基酸:酯化的邻-Chlorotrityl氯乙烯树脂与所述第一的
Doi:10.1002/hlca.19980810202

专利信息

专利号:US-10407468-B2
优先权日:2016-03-23
标 题 :Methods for synthesizing α4β7 peptide antagonists
发明人：BHANDARI ASHOK; MANTHATI SURESH KUMAR; MEHROTRA MUKUND M; ANANDAN SAMPATH-KUMAR; PATEL DINESH V
权利人:PROTAGONIST THERAPEUTICS INC
摘要:The present invention provides methods of making α4β7 peptide monomer and dimer antagonists. Methods of the present invention include solid phase and solution phase methods, as well as synthesis via condensation of smaller peptide fragments. Methods of the present invention further include methods directed to the synthesis of peptides comprising one or more penicillamine residues.

专利号:US-2022185846-A1
优先权日:2019-03-28
标 题:Methods for synthesizing beta-homoamino acids
发明人：MANTHATI SURESH KUMAR; BHANDARI ASHOK; MASJEDIZADEH MOHAMMAD REZA
权利人:PROTAGONIST THERAPEUTICS INC
摘要:Methods of making β-homoamino acids as intermediate for synthesis of peptide monmer and dimer α4β7-antagonists are disclosed. The disclosed methods include solid phase and solution phase methods.

专利号:CN-115925790-A
优先权日:2016-03-23
标 题:Method for the synthesis of α4β7 peptide antagonists