CAS: 2196-14-7; 4',7-Dihydroxyflavone

上下游产品

4'-amino-7-hydroxyflavone 4,7-dihydroxy-3-(4-hydroxy-benzoyl)-coumarin 7-benzyloxy-4'-methoxyflavone isoliquirtigenin 7-acetoxy-2-(4-acetoxy-phenyl)-chromen-4-one 2-(4-hydroxyphenyl)-7-methoxychromen-4-one 4,7-dimethoxyflavone kumatakenin B-4'-O-glucoside

异甘草素置于碘体系中,用 二甲基亚砜 用作溶剂,化学反应 0.75H,以71%的收率获得7,4'-二羟基黄酮
参考文献:异甘草素衍生物通过调节 Raw 264.7 细胞中的 P38 和 Nf-κb 激活来抑制 Rankl 诱导的破骨细胞生成
标题:异甘草素衍生物通过调节 Raw 264.7 细胞中的 P38 和 Nf-κb 激活来抑制 Rankl 诱导的破骨细胞生成
摘要:骨骼疾病可能不会立即危及生命,也不会成为心脏病或癌症等主要死亡原因.然而,随着世界几乎每个地区的人口老龄化,他们肯定会给社会带来巨大的社会经济负担,更不用说患者及其家人了.骨质疏松症是最常见的骨病类型,常发生于老年人,尤其是绝经后妇女.虽然目前有几种旨在抑制过度破骨细胞活化(骨质疏松症的主要原因)的抗破骨细胞药物可在市场上买到,但也有报道称伴随着从轻微到严重的不良反应.天然产品因其有效性和较少的副作用而变得越来越受欢迎.异甘草素 (Ilg),一种来自甘草的天然黄酮类化合物,已报道抑制破骨细胞分化和活化.在本研究中,筛选了新合成的 Ilg 衍生物作为更有效的 Ilg 替代候选物的抗骨质疏松活性.在测试的 12 种 Ilg 衍生物中,两种化合物在体外通过抑制破骨细胞生成和破骨细胞活性显着改善了骨质流失.本研究的结果表明,这些化合物可作为治疗骨质疏松症的潜在药物,值得进一步研究以评估其体内功效.
Doi:10.3390/molecules25173908

专利信息

专利号:US-2007232495-A1
优先权日:2006-03-24
标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
发明人：NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

专利号:CN-114854703-B
优先权日:2022-05-23
标 题 :A kind of flavone synthase I/flavanone-3-hydroxylase and its application in the field of synthesis of flavonoids

专利号:US-9238821-B2
优先权日:2009-04-14
标题 :Metabolic engineering for plant disease resistance
发明人：LI WENSHENG; UPPALAPATI SRINIVASA RAO; MYSORE KIRANKUMAR S; DIXON RICHARD A; SUMNER LLOYD W
权利人:LI WENSHENG; UPPALAPATI SRINIVASA RAO; MYSORE KIRANKUMAR S; DIXON RICHARD A; SUMNER LLOYD W; SAMUEL ROBERTS NOBLE FOUND INC
摘要:The invention provides methods and compositions for making a dicotyledonous plant that is susceptible to Phymatotrichopsis Root Rot (PRR) more resistant to PRR, by metabolic engineering of the plant's flavonoid and isoflavonoid biosynthetic pathways. Thus, methods for increasing the synthesis and accumulation of medicarpin and/or 7,4′-dihydroxyflavone in plants such as alfalfa are provided.