CAS: 37535-52-7; H-D-2-Pal-Oh

相似化合物

37535-51-6 17407-44-2 185379-39-9

上下游产品

(E)-3-(2-pyridyl)acrylic acid pyridine-2-carbaldehyde (S)-2-amino-3-(pyridin-2-yl)propanoic acid α-acetyl-β-(2-pyridyl)-L-alanineNα-acetyl-β-(2-pyridyl)-L-alanine 3-Pyridin-2-yl-2-(3-trifluoromethyl-benzylamino)-propionic acid 2-(4-Chloro-benzylamino)-3-pyridin-2-yl-propionic acid 2-(4-Bromo-benzylamino)-3-pyridin-2-yl-propionic acid D,L-β-(2-pyridyl)-α-alanine

3-吡啶-2-基丙-2-烯酸置于ammonium Hydroxide体系中,化学反应 2.0H,以89%的收率获得
参考文献:苯丙氨酸解氨酶通过 Mio 辅因子非依赖性途径催化合成氨基酸
标题:苯丙氨酸解氨酶通过 Mio 辅因子非依赖性途径催化合成氨基酸
摘要:苯丙氨酸解氨酶 (Pal) 属于 4-亚甲基咪唑-5-酮 (Mio) 辅因子依赖性酶家族,其负责在真核生物和原核生物中将l-苯丙氨酸转化为反式肉桂酸.在高氨浓度条件下,这种脱氨反应是可逆的,因此人们对开发 Pal 作为非天然氨基酸的对映选择性合成的生物催化剂有相当大的兴趣.在此发现了一种以前未观测到的竞争性 Mio 非依赖性反应途径,该反应途径以非立体选择性方式进行并导致l-和d的产生描述了-苯丙氨酸衍生物.通过同位素标记研究和关键活性位点残基的诱变探索了 Mio 非依赖性途径的机制.获得的结果与通过逐步 E 1 Cb 消除机制发生的氨基酸脱氨基作用一致.
Doi:10.1002/anie.201311061

专利信息

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-2025084410-A1
优先权日:2015-01-12
标 题:Incorporation of unnatural nucleotides and methods thereof
发明人：PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
权利人:SYNTHORX INC
摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

专利号:US-2018371021-A1
优先权日:2017-05-11
标 题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2009264300-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries