CAS: 5307-99-3; 7,7-Dichlorobicyclo[3.2.0]Hept-2-En-6-One

相似化合物

13173-09-6 92998-64-6 71155-04-9

上下游产品

CAS号79-36-7 二氯乙酰氯 | CAS号542-92-7 环戊二烯 | CAS号76-02-8 三氯乙酰氯 | CAS号20618-08-0 3,3-dichloropro... | CAS号78133-61-6 (1S,4S,5S)-7,7-... | CAS号4342-33-0 Acetic acid,2,2... | CAS号25436-07-1 三甲基硅基三氯乙酸 | CAS号533-75-5 环庚三烯酚酮 | CAS号1521-45-5 7-bicyclo[3.2.0... | CAS号2422-86-8 bicyclo[3.2.0]h... | CAS号34638-25-0 (1R,5S)-(+)-2-氧... | CAS号13173-09-6 双环[3,2,0]庚-2-烯-6-酮

(1S,4S,5S)-7,7-Dichloro-2,4-Bis(Trimethylsilyl)Bicyclo[3.2.0]Hept-2-En-6-One置于硫酸体系中,用 甲醇 作为反应溶剂,化学反应 18.0H,以37%的收率获得产物7,7-二氯二环[3.2.0]庚-2-烯-6-酮
参考文献:双(三甲基甲硅烷基)环戊二烯与二氯酮的反应,以及n-苯基马来酰亚胺与两个甲硅烷基化的甲基环戊二烯之间的狄尔斯-阿尔德反应
标题:双(三甲基甲硅烷基)环戊二烯与二氯酮的反应,以及n-苯基马来酰亚胺与两个甲硅烷基化的甲基环戊二烯之间的狄尔斯-阿尔德反应
摘要:双(三甲基甲硅烷基)环戊二烯与二氯酮反应,仅得到衍生自2,5-二甲硅烷基化的异构体(5)的加合物(7).甲基(三甲基甲硅烷基)环戊二烯(18)和三甲基甲硅烷基甲基环戊二烯(21)得到狄尔斯-阿尔德加合物(19)和(20),(22)和(23),其中区域选择性不受甲硅烷基的影响.加合物(22)的环氧化和环氧化物的酸催化的开口导致在甲硅烷基的存在控制下的重排中形成外-亚甲基降冰片烷(26).
DOI:10.1039/p19810000684

专利信息

专利号:US-11441163-B2
优先权日:2020-05-14
标 题:Enzyme-catalyzed synthesis of (1S,5R)-bicyclolactone
发明人：CHEN FENER; ZHU KEJIE; HUANG ZEDU; CHENG DANG; WANG JIAQI; TAO YUAN
权利人:UNIV FUDAN
摘要:An enzyme-catalyzed synthesis of (1S,5R)-bicyclolactone. A first genetically-engineered bacterium containing Baeyer-Villiger monooxygenase gene and a second genetically-engineered bacterium containing glucose dehydrogenase gene are constructed and then suspended with culture medium to prepare a first suspension and a second suspension, respectively. The first and second suspensions are centrifuged to respectively produce a first supernatant containing Baeyer-Villiger monooxygenase and a second supernatant containing glucose dehydrogenase, which are mixed. The mixed supernatant is then mixed with a raceme of a substituted bicyclo[3.2.0]-hept-2-en-6-one, a solvent, a hydrogen donor and a cofactor to perform an asymmetric Baeyer-Villiger oxidation to produce the (1S,5R)-bicyclolactone, where an amino acid sequence of the Baeyer-Villiger monooxygenase is shown in SEQ ID NO:1.

专利号:RU-2381221-C2
优先权日:2008-06-16
标题 :Method for synthesis of (+)- and (-)-3-oxabicyclo[3,3,0]oct-6-en-2-ones

专利号:US-2021355516-A1
优先权日:2020-05-14
标 题 :Enzyme-catalyzed synthesis of (1s,5r)-bicyclolactone