CAS: 82097-01-6; 2-(2-Chloroethoxy)Benzenesulfonamide

该化合物是一种磺酰胺衍生物,其特点是其氯氧功能组,这增强了其在有机合成中的活性.该化合物因其能够进行核生殖替代反应,在制药和农用化学的准备中特别有用.苯乙酰氨酸盐混合物提供了稳定性,而氯氧基副链则提供了进一步功能化的多功能性.其明确界定的结构和一贯纯度使其适合研究和工业应用,需要精确的化学修改.该化合物通常在受控制的条件下处理,以确保合成途径的最佳性能.

英文名称2-(2-Chloroethoxy)Benzenesulfonamide
中文名称2-(2-氯乙氧基)苯磺酰胺
IUPAC名称2-(2-chloroethoxy)benzenesulfonamide
其它别名邻氯乙氧基苯磺酰胺; Triasulfuron Metabolite
CAS编号82097-01-6
MFCD编号:MFCD03265372
FDA UNII编号:C794426AN5
分子式:C8H10ClNO3S
分子量:235.69
产品CID: 1812650
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: WAJIUYJWAGLDAC-UHFFFAOYSA-N
InChI=1S/C8H10ClNO3S/c9-5-6-13-7-3-1-2-4-8(7)14(10,11)12/h1-4H,5-6H2,(H2,10,11,12)…
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数4.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
安全声明H303+H313+H333

上下游产品

CAS号82097-50-5 醚苯磺隆

合成工艺路线路线简述

111762-23-3 = 82097-01-6 [标题:Reaction Conditions
标题:Process For The Preparation Of 2-Alkoxybenzenesulfonamides Useful As Herbicide Intermediates
参考文献:European Patent Organization]

13001-28-0 = 82097-01-6
反应条件:1.1 Reagents: Chlorosulfonic Acid Solvents: Hexane; Rt -> 50 °C; 30 Min,50 °C; 1 H,50 °C2.1 Solvents: Water; Rt -> 60 °C2.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 73.1 Reagents: Phosgene Solvents: Dimethylformamide,Chlorobenzene; 1 H,80 - 85 °C
标题:Improved Process For The Synthesis 2-(2-Chloroethoxy)Benzene Sulfonamide
作者:Jiang,Chunyan
参考文献:Xiandai Nongyao 日期:2004 卷标:3(2) 页码:13-14]

96-49-1 + 3724-14-9 = 82097-01-6
反应条件:1.1 Reagents: Imidazole; Rt -> 90 °C; 4 H,160 °C2.1 Reagents: Thionyl Chloride Solvents: Dimethylacetamide; 0 °C; 30 Min,15 °C2.2 Solvents: Dichloromethane; 1 H,Rt
标题:Discovery Of Ortho-Alkoxy Substituted Novel Sulfonylurea Compounds That Display Strong Herbicidal Activity Against Monocotyledon Grasses
作者:Wang,Hai-Lian; Et Al
参考文献:Journal Of Agricultural And Food Chemistry 日期:2021 卷标:69(30) 页码:8415-8427]

111755-99-8 = 82097-01-6 [标题:Reaction Conditions
标题:Process For The Preparation Of 2-Alkoxybenzenesulfonamides Useful As Herbicide Intermediates
参考文献:European Patent Organization]

111762-23-3 = 82097-01-6
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 50 - 60 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; 2 H,Ph 7 - 9,Rt
标题:Improved Process For The Synthesis 2-(2-Chloroethoxy)Benzene Sulfonamide
作者:Jiang,Chunyan
参考文献:Xiandai Nongyao 日期:2004 卷标:3(2) 页码:13-14]

87483-80-5 = 82097-01-6
反应条件:1.1 Reagents: Thionyl Chloride Solvents: Dimethylacetamide; 0 °C; 30 Min,15 °C1.2 Solvents: Dichloromethane; 1 H,Rt
标题:Discovery Of Ortho-Alkoxy Substituted Novel Sulfonylurea Compounds That Display Strong Herbicidal Activity Against Monocotyledon Grasses
作者:Wang,Hai-Lian; Et Al
参考文献:Journal Of Agricultural And Food Chemistry 日期:2021 卷标:69(30) 页码:8415-8427]

111755-99-8 + 111762-20-0 = 82097-01-6
反应条件:1.1 Reagents: Phosgene Solvents: Dimethylformamide,Chlorobenzene; 1 H,80 - 85 °C
标题:Improved Process For The Synthesis 2-(2-Chloroethoxy)Benzene Sulfonamide
作者:Jiang,Chunyan
参考文献:Xiandai Nongyao 日期:2004 卷标:3(2) 页码:13-14]

111762-20-0 = 82097-01-6
反应条件:1.1 Reagents: Ammonia Solvents: Water; < 70 °C; 3 H,30 °C2.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 50 - 60 °C2.2 Reagents: Sodium Hydroxide Solvents: Water; 2 H,Ph 7 - 9,Rt
标题:Improved Process For The Synthesis 2-(2-Chloroethoxy)Benzene Sulfonamide
作者:Jiang,Chunyan
参考文献:Xiandai Nongyao 日期:2004 卷标:3(2) 页码:13-14]

111762-20-0 = 82097-01-6 [标题:Reaction Conditions
标题:Process For The Preparation Of 2-Alkoxybenzenesulfonamides Useful As Herbicide Intermediates
参考文献:European Patent Organization]

767248-65-7 = 82097-01-6
反应条件:1.1 Solvents: Water; Rt -> 60 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 72.1 Reagents: Phosgene Solvents: Dimethylformamide,Chlorobenzene; 1 H,80 - 85 °C
标题:Improved Process For The Synthesis 2-(2-Chloroethoxy)Benzene Sulfonamide
作者:Jiang,Chunyan
参考文献:Xiandai Nongyao 日期:2004 卷标:3(2) 页码:13-14]

20677-52-5 + 13001-28-0 = 82097-01-6 [标题:Reaction Conditions
标题:Process For The Preparation Of 2-Alkoxybenzenesulfonamides Useful As Herbicide Intermediates
参考文献:European Patent Organization

醚苯磺隆置于盐酸体系中,用乙腈作为反应溶剂,以53%的收率获得产物2-(2-氯乙氧基)苯磺酰胺
参考文献:Kinetics And Hydrolysis Mechanism Of Triasulfuron
标题:Kinetics And Hydrolysis Mechanism Of Triasulfuron
摘要:The Hydrolysis Of The Sulfonylurea Herbicide Triasulfuron [(2-(2-Chloroethoxy)-N-[[4-Methoxy-6-Methyl-1,3,5-Triazin-2-yl) Amino] Carbonyl]Benzenesulfonamide] Was Studied In Aqueous Buffers Of Ph Values 2,3,4,5,6,7,And 9. The Reaction Was Of First-Order And Ph-Dependent. Triasulfuron Was More Persistent In Neutral Or Weakly Basic Than In Acidic Solution. Five Metabolites Have Been Isolated And Identified. At All Ph Values Studied,The Primary Pathway Of Degradation Was The Cleavage Of The Sulfonylurea Bridge. However,Minor Degradation Pathways Have Also Been Observed Like O-Demethylation And Opening Of The Triazine Ring. The Product Distribution Was Ph-Dependent.
DOI:10.1021/jf970299D