CAS: 93-09-4; 2-Naphthoic Acid

• 英文名称2-Naphthoic Acid
• 中文名称2-萘甲酸
• IUPAC名称2-naphthoic acid
• 其它别名2-萘甲酸; 2-萘甲酸 99% Min; β萘甲酸; Naphthalene-2-Carboxylic Acid
• CAS编号93-09-4
• MFCD编号:MFCD00004101
• EINECS号:202-217-8
• FDA UNII编号:QLG01V0W2L
• 分子式:C11H8O2
• 分子量:172.18
• 产品CID: 2463226
• 产品分类有机原料→分子砌块→芳环类化合物→萘类化合物

• 相似结构搜索
• 产品信息参考;;;;
• InChIKey: UOBYKYZJUGYBDK-UHFFFAOYSA-N
• InChI=1S/C11H8O2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H,12,13)…
• 计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数1.0

相似化合物

物理性质

• 熔点185-187°C
• 沸点332.9±11.0 °C at 760 mmHg
• 闪点151.3±13.9 °C
• 密度1.3±0.1 g/cm3
• PH:4.5 (H2O, 20°C)
• pKa:4.17(at 25°C)
• PSA:37.3
• LogP:2.538
• 折射率1.673
• 蒸汽压0.0±0.8 mmHg at 25°C
• 溶解性Alcohol: Soluble
• 外观形态白色至米色粉末
• 储存条件密封, 常温干燥保存
• 产品应用用作有机合成中间体及植物生长调节剂.
• 性质描述白色片状或针状结晶.熔点185.5°C,沸点300°C.溶于醚和醇,微溶于热水.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  特定目标器官毒性 - 单次接触 类别3
  严重眼刺激 类别2A
• 警示词Warning(警告)
• 危险描述H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H335 |可能引起呼吸道刺激.
  H320 |会刺激眼睛
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
• UN编号NONH for all modes of transport
• 危险品标志Xi
• 安全声明26-36-24/25-36/373/39
• 危险类别码36/37/38
• WGK Germany2

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 2-Naphthoic Acid 主要起始原料 6-Bromo-2-Naphthoic Acid
• 66-99-9 = 93-09-4
  反应条件:1.1 Reagents: Methanesulfinic Acid,1,1,1-Trifluoro-,Sodium Salt (1:1),Oxygen Solvents: Acetonitrile; 12 H,1 Atm,Rt
  标题:Aerobic Oxidation System Containing Sulfinic Acid,Sulfonic Acid Or Derivatives Thereof And Photocatalytic Oxidation Method Therefor
  参考文献:World Intellectual Property Organization]
  
  66-99-9 = 93-09-4
  反应条件:1.1 Reagents: Oxygen Catalysts: Tetramesitylporphyrin Solvents: Acetonitrile,Dichloromethane; 48 H,Rt
  标题:A New And Efficient Aerobic Oxidation Of Aldehydes To Carboxylic Acids With Singlet Oxygen In The Presence Of Porphyrin Sensitizers And Visible Light
  作者:Hajimohammadi,Mahdi; Safari,Nasser; Mofakham,Hamid; Shaabani,Ahmad
  参考文献:Tetrahedron Letters 日期:2010 卷标:51(31) 页码:4061-4065]
  
  5773-80-8 = 93-09-4
  反应条件:1.1 Reagents: Potassium Acetate,Bis(Pinacolato)Diborane Catalysts: Palladium Solvents: Ethanol; 6 H,60 °C
  标题:Dimerization Of Aromatic Compounds Using Palladium-Carbon-Catalyzed Suzuki-Miyaura Cross-Coupling By One-Pot Synthesis
  作者:Du,Fangyu; Zhou,Qifan; Liu,Dongdong; Fang,Ting; Shi,Yajie; Et Al
  参考文献:Synlett 日期:2018 卷标:29(6) 页码:779-784]
  
  24091-02-9 = 93-09-4
  反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Poly(Diseleno-1,2-Phenylene) Solvents: Tetrahydrofuran,Water1.2 Reagents: Sodium Bicarbonate,Sodium Chloride Catalysts: Platinum Solvents: Water
  标题:One-Pot Oxidation Of Azomethine Compounds Into Arenecarboxylic Acids
  作者:Giurg,Miroslaw; Said,Samy B.; Syper,Ludwik; Mlochowski,Jacek
  参考文献:Synthetic Communications 日期:2001 卷标:31(20) 页码:3151-3159]
  
  101482-14-8 = 93-09-4
  反应条件:1.1 Reagents: Dimethyl Sulfoxide Catalysts: Perfluorobutyl Iodide; 27 H,Rt
  标题:Preparation Method Of Carboxylic Acid Compound Under Photopromotion
  参考文献:China]
  
  612-55-5 = 93-09-4
  反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Di-μ-Chlorobis(η3-2-Propenyl)Dipalladium (Reaction Products With Diphenylphosphane And Polystyrene-Poly(Ethylene Glycol) Resin Supported) Solvents: Acetonitrile,Water; 58 S,5 Bar,100 °C
  标题:Aqueous Flow Hydroxycarbonylation Of Aryl Halides Catalyzed By An Amphiphilic Polymer-Supported Palladium-Diphenylphosphine Catalyst
  作者:Osako,Takao; Kaiser,Reinhard; Torii,Kaoru; Uozumi,Yasuhiro
  参考文献:Synlett 日期:2019 卷标:30(8) 页码:961-966]
  
  135-19-3 = 93-09-4
  反应条件:1.1 Reagents: Triethylamine,Sulfonyl Fluoride Solvents: Dimethyl Sulfoxide; 2 - 6 H,Rt1.2 Reagents: Sodium Bicarbonate,Water Catalysts: Palladium Diacetate,1,3-Bis(Diphenylphosphino)Propane Solvents: Dimethyl Sulfoxide; 12 H,60 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 1 - 2
  标题:So2F2-Mediated One-Pot Synthesis Of Aryl Carboxylic Acids And Esters From Phenols Through A Pd-Catalyzed Insertion Of Carbon Monoxide
  作者:Fang,Wan-Yin; Leng,Jing; Qin,Hua-Li
  参考文献:Chemistry - An Asian Journal 日期:2017 卷标:12(17) 页码:2323-2331]
  
  1916516-62-5 = 93-09-4
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 11 H,100 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified
  标题:Dithioester-Enabled Chemodivergent Synthesis Of Acids,Amides And Isothiazoles Via C-C Bond Cleavage And C-O/c-N/c-S Bond Formations Under Metal- And Catalyst-Free Conditions
  作者:Soni,Sonam; Koley,Suvajit; Singh,Maya Shankar
  参考文献:Tetrahedron Letters 日期:2017 卷标:58(25) 页码:2512-2516]
  
  76749-35-4 = 93-09-4
  反应条件:1.1 Reagents: Tert-Butyl Nitrite Solvents: Water; 35 Min,29 °C
  标题:Tert-Butyl Nitrite-Mediated Synthesis Of N-Nitrosoamides,Carboxylic Acids,Benzocoumarins,And Isocoumarins From Amides
  作者:Yedage,Subhash L.; Bhanage,Bhalchandra M.
  参考文献:Journal Of Organic Chemistry 日期:2017 卷标:82(11) 页码:5769-5781]
  
  19350-74-4 = 93-09-4
  反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Poly(Diseleno-1,2-Phenylene) Solvents: Tetrahydrofuran,Water; 20 H,Reflux
  标题:Hydrogen Peroxide Oxidation Of Naphthalene Derivatives Catalyzed By Poly(Bis-1,2-Diphenylene) Diselenide
  作者:Giurg,M.; Syper,L.; Mlochowski,J.
  参考文献:Polish Journal Of Chemistry 日期:2004 卷标:78(2) 页码:231-238]
  
  1592-38-7 = 93-09-4
  反应条件:1.1 Reagents: Oxygen Catalysts: Catalase,Galactose Oxidase,Aldehyde Oxidase Solvents: Acetonitrile,Water; Overnight,Ph 7.6,37 °C1.2 Reagents: Hydrochloric Acid Solvents: Water
  标题:Enzyme Cascade Reactions: Synthesis Of Furandicarboxylic Acid (Fdca) And Carboxylic Acids Using Oxidases In Tandem
  作者:Mckenna,Shane M.; Leimkuhler,Silke; Herter,Susanne; Turner,Nicholas J.; Carnell,Andrew J.
  参考文献:Green Chemistry 日期:2015 卷标:17(6) 页码:3271-3275]
  
  66-99-9 = 93-09-4
  反应条件:1.1 Reagents: 1-Hydroxycyclohexyl Phenyl Ketone,Sodium Hydroxide Solvents: 1,2-Dimethoxyethane; 80 °C; 80 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified,Rt
  标题:Oxidation Of Primary Alcohols And Aldehydes To Carboxylic Acids With 1-Hydroxycyclohexyl Phenyl Ketone
  作者:Lu,Yi; Tan,Wen-Yun; Ding,Yuzhen; Chen,Wen; Zhang,Hongbin
  参考文献:Journal Of Organic Chemistry 日期:2023 卷标:88(13) 页码:8114-8122]
  
  893-33-4 = 93-09-4
  反应条件:1.1 Reagents: Sodium Bicarbonate,Oxygen Catalysts: Tris(2,2′-Bipyridyl)Ruthenium(Ii) Chloride Solvents: Acetonitrile; 4 H1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified
  标题:[ru(Bpy)3]Cl2-Catalyzed Aerobic Oxidative Cleavage β-Diketones To Carboxylic Acids Under Visible Light Irradiation
  作者:Wang,Xiao-Yan; Shang,Zhen-Peng; Zha,Gao-Feng; Chen,Xiao-Qing; Bukhari,Syed Nasir Abbas; Et Al
  参考文献:Tetrahedron Letters 日期:2016 卷标:57(50) 页码:5628-5631]
  
  53531-11-6 = 93-09-4
  反应条件:1.1 Reagents: Boron Trifluoride Etherate Solvents: Toluene; Rt -> 80 °C; 2 H,80 °C
  标题:Method For Preparing Carboxylic Acid By Removing Benzyl Protection From Benzyl Carboxylate
  参考文献:China]
  
  1592-38-7 = 93-09-4
  反应条件:1.1 Solvents: Dichloromethane; 2 H
  标题:Clean And Selective Oxidation Of Aromatic Alcohols Using Silica-Supported Jones' Reagent In A Pressure-Driven Flow Reactor
  作者:Wiles,Charlotte; Watts,Paul; Haswell,Stephen J.
  参考文献:Tetrahedron Letters 日期:2006 卷标:47(30) 页码:5261-5264]
  
  19350-74-4 = 93-09-4
  反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: 2-[[[3-(Trihydroxysilyl)Propyl]Amino]Seleno]Benzoyl Chloride (Silica-Supported) Solvents: Tetrahydrofuran,Water; Rt; 50 H,55 °C1.2 Reagents: Sodium Bicarbonate,Sodium Chloride Solvents: Water1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 2
  标题:Hydroperoxide Oxidation Of Different Organic Compounds Catalyzed By Silica-Supported Selenenamide
  作者:Giurg,M.; Brzaszcz,M.; Mlochowski,J.
  参考文献:Polish Journal Of Chemistry 日期:2006 卷标:80(3) 页码:417-428]
  
  101482-14-8 = 93-09-4
  反应条件:1.1 Reagents: Dimethyl Sulfoxide,Perfluorobutyl Iodide; 27 H,Rt
  标题:Transformation Of Thioacids Into Carboxylic Acids Via A Visible-Light-Promoted Atomic Substitution Process
  作者:Wang,Rui; Xie,Kai-Jun; Fu,Qiang; Wu,Min; Pan,Gao-Feng; Et Al
  参考文献:Organic Letters 日期:2022 卷标:24(10) 页码:2020-2024]
  
  580-13-2 = 93-09-4
  反应条件:1.1 Reagents: Poly(Methylhydrosiloxane) Catalysts: Cupric Acetate,1,2-Bis(Diphenylphosphino)Benzene Solvents: 1,4-Dioxane; 25 Min,60 °C1.2 Reagents: Triethylamine Catalysts: Palladium Diacetate,1,1′-(9,9-Dimethyl-9H-Xanthene-4,5-Diyl)Bis[1,1-Diphenylphosphine] Solvents: Toluene; 3 H,100 °C; 100 °C -> Rt1.3 Reagents: Sodium Hydroxide Solvents: Water; 10 Min,Rt1.4 Reagents: Hydrochloric Acid Solvents: Water; Ph 1 - 2
  标题:Method For Preparing Aromatic Carboxylic Acid Compound
  参考文献:China]
  
  580-13-2 = 93-09-4
  反应条件:1.1 Reagents: Poly(Methylhydrosiloxane) Catalysts: Cupric Acetate,1,2-Bis(Diphenylphosphino)Benzene Solvents: 1,4-Dioxane; 20 Min,Rt -> 65 °C1.2 Reagents: Triethylamine Catalysts: Palladium Diacetate,1,1′-(9,9-Dimethyl-9H-Xanthene-4,5-Diyl)Bis[1,1-Diphenylphosphine] Solvents: Toluene; 3 H,Rt -> 100 °C; 100 °C -> Rt1.3 Reagents: Sodium Bicarbonate Solvents: Water; 10 Min,Rt
  标题:Tandem One-Pot Co2 Reduction By Pmhs And Silyloxycarbonylation Of Aryl/vinyl Halides To Access Carboxylic Acids
  作者:Paridala,Kumaraswamy; Lu,Sheng-Mei; Wang,Meng-Meng; Li,Can
  参考文献:Chemical Communications (Cambridge 日期:2018 卷标:54(82) 页码:11574-11577]
  
  = 93-09-4
  反应条件:1.1 Reagents: Dimethyl Sulfide,N-Bromosuccinimide,4-Hydroxy-2-Methoxybenzenemethanol (Polymer Supported) Solvents: Dichloromethane1.2 Reagents: Dimethylacetamide Catalysts: 18-Crown-61.3 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane
  标题:Efficient Synthesis Of Benzylic Bromides Under Neutral Conditions On Solid Support
  作者:Zoller,T.; Ducep,J.-B.; Hibert,M.
  参考文献:Tetrahedron Letters 日期:2000 卷标:41(51) 页码:9985-9988]
  
  = 93-09-4 + 80166-90-1
  反应条件:1.1 Reagents: Water Solvents: Dichloromethane,1,4-Dioxane
  标题:5-Bromo-7-Nitroindoline
  作者:Michael,Katja
  参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2007

海关参考信息

• 2902902000-精萘
  2905110000-甲醇
  2906210000-苄醇
  2912110000-甲醛
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• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
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