CAS: 939412-86-9; (3-Chloropyrazin-2-yl)Methanamine Hydrochloride

• 英文名称(3-Chloropyrazin-2-yl)Methanamine Hydrochloride
• 中文名称(3-氯吡嗪-2-基)甲胺盐酸盐
• IUPAC名称(3-chloropyrazin-2-yl)methanamine hydrochloride
• 其它别名(3-氯吡嗪-2-基)甲胺盐酸; 3-Chloropyrazine-2-Yl-Methylamine Hydrochloride
• CAS编号939412-86-9
• MFCD编号:MFCD09910171
• EINECS号:686-960-7
• 分子式:C5H7Cl2N3
• 分子量:180.04
• 产品CID: 1983056
• 产品分类有机原料→分子砌块→芳杂环类化合物→吡嗪类化合物

• 相似结构搜索
• InChIKey: YYVVOYJKQZWKFS-UHFFFAOYSA-N
• InChI=1S/C5H6ClN3.ClH/c6-5-4(3-7)8-1-2-9-5;/h1-2H,3,7H2;1H…
• 计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数1.0

相似化合物

物理性质

• PSA:51.8
• LogP:1.0105
• 外观形态黄色固体
• 储存条件在惰性气体(氮气或氩气)下 2-8°C

MSDS等安全信息

• GHS象形图
• GHS符号GHS07 & GHS05;
  注释: Exclamation mark & Corrosion
• 危险类别急性毒性 类别4(经口)
  严重眼损伤 类别1
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2A
• 警示词Danger(危险)
• 危险描述H302 |吞咽有害.
  H318 |造成严重眼损伤.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
• 危险品标志Xi

欧盟法规

合成工艺路线路线简述

• 合成目标产物 (3-Chloropyrazin-2-yl)Methanamine Hydrochloride 主要起始原料 3-Chloropyrazine-2-Carbonitrile
• 55557-52-3 = 939412-86-9
  反应条件:1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Acetic Acid; 1.5 D,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water
  标题:Imidazopyrazine Compound Useful In Treatment Of Various Diseases And Its Preparation
  参考文献:World Intellectual Property Organization]
  
  55557-52-3 = 939412-86-9
  反应条件:1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Acetic Acid,Water; Overnight,4 Bar,Rt1.2 Reagents: Hydrochloric Acid Solvents: Diethyl Ether,Ethyl Acetate; 30 Min,Cooled; > 1 D,Rt
  标题:Therapeutic Combinations Of A Btk Inhibitor,A Pi3K Inhibitor,A Jak-2 Inhibitor And/or A Cdk4/6 Inhibitor
  参考文献:World Intellectual Property Organization]
  
  55557-52-3 = 939412-86-9
  反应条件:1.1 Reagents: Acetic Acid,Hydrogen Catalysts: Nickel Solvents: Water; Overnight,4 Bar,Rt1.2 Reagents: Hydrochloric Acid Solvents: Diethyl Ether,Ethyl Acetate; 50 °C; Cooled; 30 Min; > 1 D,Rt
  标题:Bicyclic Heterocycles As Btk Inhibitors And Their Preparation
  参考文献:World Intellectual Property Organization]
  
  55557-52-3 = 939412-86-9
  反应条件:1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Acetic Acid; 4.5 - 5 Kg/cm2,30 °C -> 45 °C; 3 H,40 - 45 °C
  标题:Improved Process For The Preparation Of 4-{8-Amino-3-[(2S)-1-(But-2-Ynoyl)Pyrrolidin-2-Yl]Imidazo[1,5-A]Pyrazin-1-Yl)}-N-(Pyridine-2-Yl)Benzamide
  参考文献:India]
  
  = 939412-86-9 [标题:Reaction Conditions
  标题:4-Imidazopyridazin-1-Yl-Benzamides And 4-Imidazotriazin-1-Yl-Benzamides Btk Inhibitors
  参考文献:United States]
  
  1823551-51-4 = 939412-86-9
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Isopropanol; 25 - 30 °C; 1 H,50 - 55 °C; 35 °C -> 5 °C; 1 H,0 - 5 °C
  标题:Improved Process For Preparation Of Intermediates Of Brutons Tyrosine Kinase Inhibitor
  参考文献:India]
  
  55557-52-3 = 939412-86-9
  反应条件:1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Acetic Acid,Water; Overnight,4 Bar,Rt1.2 Solvents: Ethyl Acetate; 50 °C; Cooled1.3 Reagents: Hydrochloric Acid Solvents: Diethyl Ether; 30 Min,Cooled; > 1 D,Rt
  标题:Preparation Of Imidazopyridazinylbenzamide Derivatives And Analogs For Use As Btk Inhibitors
  参考文献:World Intellectual Property Organization]
  
  55557-52-3 = 939412-86-9
  反应条件:1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Acetic Acid,Water; Overnight,4 Bar,Rt1.2 Reagents: Hydrochloric Acid Solvents: Diethyl Ether,Ethyl Acetate; 30 Min,Cooled; 2 D,Rt
  标题:Preparation Of Imidazopyrazinylbenzamide Derivatives And Analogs For Use As Btk Inhibitors
  参考文献:World Intellectual Property Organization]
  
  55557-52-3 = 939412-86-9
  反应条件:1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Acetic Acid,Water; Overnight,4 Bar,Rt1.2 Reagents: Hydrochloric Acid Solvents: Diethyl Ether,Water; 30 Min,0 °C; > 1 D,Rt
  标题:Therapeutic Combinations Of A Btk Inhibitor,A Pi3K Inhibitor,A Jak-2 Inhibitor,And/or A Bcl-2 Inhibitor
  参考文献:World Intellectual Property Organization]
  
  55557-52-3 = 939412-86-9
  反应条件:1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Acetic Acid,Water; Overnight,4 Bar,Rt1.2 Reagents: Hydrochloric Acid Solvents: Diethyl Ether,Ethyl Acetate; 30 Min,Cooled; > 1 D,Rt
  标题:Therapeutic Combinations Of A Btk Inhibitor,A Pi3K Inhibitor,A Jak-2 Inhibitor,A Pd-1 Inhibitor And/or A Pd-L1 Inhibitor
  参考文献:World Intellectual Property Organization]
  
  55557-52-3 = 939412-86-9
  反应条件:1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Acetic Acid; 48 H,1 Mpa,Rt
  标题:Preparation Of Imidazo[1,5-A]Pyrazine Derivatives As Btk Inhibitors
  参考文献:World Intellectual Property Organization]
  
  771581-15-8 = 939412-86-9
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Ethyl Acetate
  标题:Preparation Of Deurated Imidazopyrazines Useful As Selective Btk Inhibitors
  参考文献:China]
  
  55557-52-3 = 939412-86-9
  反应条件:1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Acetic Acid,Water; 15 H,4 Bar,Rt1.2 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane,Ethyl Acetate; Cooled; 18 H,Rt
  标题:Preparation Of Heteroaromatic Nmda Receptor Modulators For Treating Neuropsychiatric Disorders
  参考文献:World Intellectual Property Organization]
  
  55557-52-3 = 939412-86-9
  反应条件:1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Acetic Acid; 48 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Rt
  标题:Preparation Of Pyrazolopyridinamines,Pyrazolopyrimidinamines And Imidazopyrazinamines As Tyrosine Kinase Inhibitors
  参考文献:World Intellectual Property Organization]
  
  = 939412-86-9
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Methanol,Water; 1 H,Rt -> Reflux1.2 Reagents: Sodium Carbonate Solvents: Water
  标题:Process For The Preparation Of Substituted Imidazo[1,5-A]Pyrazines
  参考文献:United States]
  
  = 939412-86-9 [标题:Reaction Conditions
  标题:Btk Inhibitors To Treat Solid Tumors Through Modulation Of The Tumor Microenvironment
  参考文献:World Intellectual Property Organization

专利信息

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管