3-氯丙烯置于氯体系中,化学反应生成顺式-1,3-二氯丙烯,反式-1,3-二氯-1-丙烯 参考文献:The High Temperature Chlorination Of Various Mono-And Dichloropropenes 标题:The High Temperature Chlorination Of Various Mono-And Dichloropropenes 摘要: Doi:10.1021/ja01102A037
专利信息
专利号:US-9765077-B2 优先权日:2015-05-29 标题:Synthesis of duocarmycin analogues 发明人:STEPHENSON MICHAEL J; HOWELL LESLEY A; SEARCEY MARK 权利人:UNIV OF EAST ANGLIA 摘要:A novel Fmoc protected duocarmycin subunit and utilization as a reagent in solid phase protein synthesis methodology. Also provided is a novel method of solid phase peptide synthesis, and in particular a method for the production of novel intermediates and novel monomeric and extended duocarmycin analogues having amino acid substituents.
专利号:US-4479859-A 优先权日:1983-12-27 标 题 :Laser photochemical synthesis of benzene and its derivatives 发明人:MCDONALD JOSEPH K; MERRITT JAMES A 权利人:US ARMY 摘要:A cw CO2 tunable laser is employed to irradiate an allyl halide selected from allyl chloride, allyl bromide, allyl fluoride, 2-methyl-3-chloropropene, and 2,3-dichloropropene and contained in one or more reaction cells at a predetermined pressure. A predetermined power level from about 25 to 150 watts, an irradiating time from about 0.2 second to about 60 seconds, and a selected radiation line for example P(36), P(32), P(28), P(26), or P(22) (that is resonant with an absorption band of the selected allyl halide) are employed to achieve dissociation of the selected allyl halide and to achieve a laser-induced photochemical synthesis of benzene and substituted benzenes.
专利号:US-6310209-B1 优先权日:1997-12-08 标题:Synthesis of CC-1065/duocarmycin analogs 发明人:BOGER DALE L 权利人:SCRIPPS RESEARCH INST 摘要:The present invention relates to a method for the synthesis of the dihydroindole C-ring found in CC-1065/duocarmycin analogs.
专利号:US-7329760-B2 优先权日:2002-04-05 标题 :CC-1065 analog synthesis 发明人:ZHAO ROBERT YONGXIN; CHARI RAVI V J 权利人:IMMUNOGEN INC 摘要:Improved synthesis of seco(−)CBI (5-hydroxy-3-amino-1-[S]-(chloromethyl)-1,2-dihydro-3H-benz(e)indole): n nand improved syntheses therefrom of a wide variety of CC-1065 analogs that comprise a cyclopropabenzidole (CBI) alkylating moiety, and which are collectively DC1 and its derivatives, for the synthesis of cell-targeted therapeutic agents.
专利号:US-2009088576-A1 优先权日:2006-01-30 标题:Process for the Stereoselective Preparation of Alcohols From Alpha, Beta-Insaturated Compounds 发明人:HEROLD PETER; STUTZ STEFAN; MAH ROBERT; STOJANOVIC ALEKSANDAR; LYOTHIER ISABELLE; BEHNKE DIRK; SPINDLER FELIX; BAPPERT ERHARD 权利人:HEROLD PETER; STUTZ STEFAN; MAH ROBERT; STOJANOVIC ALEKSANDAR; LYOTHIER ISABELLE; BEHNKE DIRK; SPINDLER FELIX; BAPPERT ERHARD 摘要:A process for the synthesis of an alcohol of formula (I), using as intermediate a compound of formula (V).
专利号:US-8541524-B2 优先权日:2006-07-04 标 题 :Free-radical polymerization process in aqueous dispersion for the preparation of a block copolymer at least one block of which is a block of a halogenated polymer 发明人:FRINGANT CHRISTOPHE; VANDERVEKEN YVES; LACROIX-DESMAZES PATRICK; TONNAR JEFF 权利人:FRINGANT CHRISTOPHE; VANDERVEKEN YVES; LACROIX-DESMAZES PATRICK; TONNAR JEFF; SOLVAY 摘要:Process of controlled free-radical polymerization in aqueous dispersion for the preparation of a block copolymer at least one block of which is a block of a halogenated polymer using molecular iodine and at least one oxidant whose solubility in water is at least 10 g/l for the synthesis of the first block of the block copolymer.