CAS: 122555-91-3; Tri-Tert-Butyl 2,2',2''-(1,4,7,10-Tetraazacyclododecane-1,4,7-Triyl)Triacetate

上下游产品

CAS号5292-43-3 溴乙酸叔丁酯 | CAS号294-90-6 轮环藤宁 | CAS号107-59-5 氯乙酸叔丁酯 | CAS号10045-25-7 1,4,7,10-四氮环十二烷四盐酸盐 | CAS号137076-54-1 三叔丁基1,4,7,10-四氮...

轮环藤宁置于sodium Acetate,Potassium Carbonate体系中,用 N,N-二甲基乙酰胺,乙腈 用作溶剂,化学反应 48.5H,反应生成1,4,7,10-四氮杂环十二烷-1,4,7-三乙酸三叔丁酯
参考文献:Synthesis And Characterization Of Dota-Mono-Adamantan-1-Ylamide
标题:Synthesis And Characterization Of Dota-Mono-Adamantan-1-Ylamide
摘要:通过 1,4,7-三(叔丁氧羰基甲基)-1,4,7,10-四氮杂环十二烷 (5) 和 N-(金刚烷-1-基) 溴乙酰胺 (2) 的亲核取代反应,合成了一种新型的金刚烷官能化 1,4,7,10-四乙酸 (Dota) 螯合剂.傅立叶变换红外光谱(ft-Ir),1H 核磁共振(NMR),13C NMR,常压电离电喷雾质谱(api-Es-Ms)和元素分析对中间体和目标化合物(7)进行了表征.
Doi:10.1007/s11164-014-1615-8

专利信息

专利号:US-10189803-B2
优先权日:2008-02-22
标题 :Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
发明人：CHONG HYUN-SOON
权利人:CHONG HYUN SOON; ILLINOIS INSTITUTE OF TECH
摘要:Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

专利号:US-2008312430-A1
优先权日:2004-10-20
标题:Method of Preparing or Synthesizing Polyazamacrocycle Derivatives
发明人：CIHELNIK SIMON; DROZ LADISLAV; SRAMEK MARTIN
权利人:THERAPHARM GMBH
摘要:The present invention relates to novel processes for the synthesis of polyazamacrocycle derivatives. Furthermore, the present invention relates to novel polyazamacrocycle derivatives as well as novel intermediates for the synthesis of said polyazamacrocycle derivatives.

专利号:US-8138332-B2
优先权日:2005-04-19
标题 :Synthesis of cyclen derivatives
发明人：AXELSSON OSKAR; OLSSON ANDREAS
权利人:AXELSSON OSKAR; OLSSON ANDREAS; GE HEALTHCARE AS
摘要:The invention relates to an improved process for preparation of protected DO3A, such as DO3A-tri-t-butyl ester (1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid tri-t-butyl ester). The compound is prepared as a salt. The process includes a work-up procedure giving DO3A-tri-t-butyl ester as a salt of excellent purity.

专利号:US-9981953-B1
优先权日:2017-01-04
标题 :Contrast agent precursor and method for preparing the same
发明人：WU WEN-CHING; LU KUEI-LIN; CHANG YU; HSU CHENG-FANG
权利人:INER AEC EXECUTIVE YUAN
摘要:A contrast agent precursor is revealed. The contrast agent precursor includes a 1,4,7-Tris(carbonylmethyl)-1,4,7,10-tetraazacyclododecane that forms complexes with radioisotopes or connects to a peptide. The contrast agent precursor also includes a 2-nitroimidazole that allows the precursor to become retained in hypoxic tissues According to the features mentioned above, the contrast agent prepared by the precursor has a better binding specificity, labeling accuracy and detection sensitivity. Moreover, a method for preparing the contrast agent precursor not only solves the emulsion problem generated during conventional synthesis of intermediate products but also provides a solution to the problem of residual trifluoroacetic acid. Both the yield rate and the purity of the final product are also improved.

专利号:AT-E545636-T1
优先权日:2005-04-19
标题 :SYNTHESIS OF CYCLE DERIVATIVES

专利号:US-2019292206-A1
优先权日:2018-03-22
标 题 :Gadolinium complex, method for synthesis of the gadolinium complex, and mri contrast agent including the gadolinium complex