CAS: 150238-87-2; Arldvasefrkkwnkwalsr-Nh2

上下游产品

Fm°C-Val-OH Fm°C-Leu-OH N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine N-Fm°C L-Phe

Fmoc-L-缬氨酸,Fmoc-L-亮氨酸,Fmoc-L-丙氨酸,Fmoc-L-苯丙氨酸,Fmoc-O-叔丁基-L-丝氨酸,Fmoc-L-天冬氨酸 Beta-叔丁酯,Fmoc-O-叔丁基-L-谷氨酸,N-Alpha-芴甲氧羰基-N-Epsilon-叔丁氧羰基-L-赖氨酸,Fmoc-N-三苯甲基-L-天冬酰胺,Fmoc-L-色氨酸(Boc)-Oh,Fmoc-Pbf-L-精氨酸置于(1-Cyano-2-Ethoxy-2-Oxoethylidenaminooxy)Dimethylaminomorpholinocarbenium Hexafluorophosphate,N,N-二异丙基乙胺,2-肟氰乙酸乙酯,哌啶体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 0.08H,反应生成肾上腺髓质素n端20肽(人类)
参考文献:超声促进fmoc固相肽合成
标题:超声促进fmoc固相肽合成
摘要:我们调查了基于fmoc的固相肽合成(spps)的超声介导作用.我们的研究最终以超声辅助策略(us-Spps)的开发为基础,该策略允许合成不同的生物活性肽(最多44个单体),并显着节省了材料和反应时间.值得注意的是,超声辐射并未加剧主要的副反应,并改善了具有"困难序列"的肽的合成,从而使us-Spps成为当前高效的肽合成策略之一.
Doi:10.1021/acs.Orglett.9B02283

专利信息

专利号:US-11707519-B2
优先权日:2017-05-11
标题 :Phosphorylated heptose compounds: process for their preparation and use
发明人：COX ANDREW; SAUVAGEAU JANELLE; OSCARSON STEFAN; GUAZZELLI LORENZO
权利人:NAT RES COUNCIL CANADA; UNIV DUBLIN; UNIV COLLEGE DUBLIN NATIONAL UNIV OF IRELAND
摘要:Processes for the preparation of phosphorylated heptose compounds are provided. Embodiments of the invention relate to the chemical synthesis of heptopyranose phosphate compounds. Also, embodiments of the invention relate to the use of compounds according to the invention in modulating an immune response in a subject.

专利号:WO-2023056470-A1
优先权日:2021-09-30
标 题:MnO NANOMATERIAL BASED INHIBITORS OF INFLAMMATION AND CANCER METASTASIS
发明人：LEONG KAM W; ZHONG YILING
权利人:UNIV COLUMBIA; NEWSOUTH INNOVATIONS PTY LTD
摘要:The anionic manganese oxide nanoparticle nucleic acid scavengers are biodegradable anionic scavengers with low cytotoxicity, which are able to scavenge (bind) cell-free nucleic acids (e.g., extracellular ssRNA, dsRNA, and unmethylated DNA), providing treatment for various medical conditions. The main component of the scavenger is manganese oxide, which may be synthesized by using a manganese compound (e.g., manganese acetate) and an acid (e.g., tannic acid) at high temperature (e.g., 100-150°C). Synthesis may be performed by mixing a manganese compound and an acid in water forming a mixture, which is stirred, heated, and allowed to cool. The anionic manganese oxide nanoparticles are extracted from the cooled mixture. The typical size of the resultant nanomaterials ranges from 30 to 100 nm; the zeta potential of the as-prepared nanomaterials is about -20 mV. The nanoparticles have various uses, including administration to a subject to treat inflammation or to treat cancer.

专利号:US-2022401561-A1
优先权日:2019-09-30
标题 :Protein-macromolecule conjugates and methods of use thereof
发明人：SONG YUNTAO; LI HUI; ZHOU HAIPING; LIAO CHUAN
权利人:BEIJING XUANYI PHARMASCIENCES CO LTD
摘要:The present disclosure provides protein-macromolecule conjugates, releasable linkers, and macromolecules, as defined herein. The disclosed conjugates provide unique properties that ae based at least upon the properties of linker and number of linker-Macromolecule moieties. Also provided herein are a method of synthesis and use of conjugates in treating diseases and disorders.

专利号:WO-2007098681-A1
优先权日:2006-02-28
标题:Use of a monoterpene in manufacturing medicaments for treating diabetes mellitus
发明人：SHU GANG; YAO FENGLING
权利人:SHU GANG; YAO FENGLING
摘要:Use of a monoterpene d-limonene in the field of pharmacy, particularly use of d-limonene in manufacturing medicaments for treating diabetes mellitus. In the experiments using the rat models of type I and type II diabetes mellitus, it shows that d-limonene can decrease the fasting blood glucose level markedly, thereby it proves that d-limonene is a potent medicament for treating type I and type II diabetes mellitus. Several clinical tests have proven that d-limonene can decrease postprandial blood glucose of type II diabetes mellitus patient markedly and stably. The toxicity of d-limonene is low and thereby it shows d-limonene is highly safe when it is administered orally. The source of d-limonene is rich, its price is cheap, and the extraction method is easy. D-limonene is extracted from the peel essential oils of citrus such as lemon and orange by the methods of cold compression or fractional distillation. This novel medicament is liquid and oily compound extracted from natural plants, other than the chemical synthesis compounds such as biguanides, sulfonylureas or glucosidase inhibitors.

专利号:US-2025255984-A1
优先权日:2022-02-01
标 题 :Mno nanomaterial based inhibitors of inflammation and cancer metastasis
发明人：LEONG KAM W; ZHONG YILING
权利人:UNIV COLUMBIA; NEWSOUTH INNOVATIONS PTY LTD
摘要:The anionic manganese oxide nanoparticle nucleic acid scavengers are biodegradable anionic scavengers with low cytotoxicity, which are able to scavenge (bind) cell-free nucleic acids (e.g., extracellular ssRNA, dsRNA, and unmethylated DNA), providing treatment for various medical conditions. The main component of the scavenger is manganese oxide, which may be synthesized by using a manganese compound (e.g., manganese acetate) and an acid (e.g., tannic acid) at high temperature (e.g., 100-150° C.). Synthesis may be performed by mixing a manganese compound and an acid in water forming a mixture, which is stirred, heated, and allowed to cool. The anionic manganese oxide nanoparticles are extracted from the cooled mixture. The typical size of the resultant nanomaterials ranges from 30 to 100 nm; the zeta potential of the as-prepared nanomaterials is about −20 mV. The nanoparticles have various uses, including administration to a subject to treat inflammation or to treat cancer.

专利号:US-2015050313-A1
优先权日:2013-08-16
标 题:Novel immunostimulants and synthesis thereof
发明人：MANCINI ROCK J; TOM JANINE K; ESSER-KAHN AARON P
权利人:UNIV CALIFORNIA
摘要:Disclosed herein are heteromeric molecules comprising two or more different pathogen associated molecular patterns (PAMPs), wherein the two or more PAMPs are linked together with discrete, linear inter-PAMP spacing. Also disclosed are immunogenic compositions comprising the heteromeric molecules and related methods of stimulating an immune response in vivo in a subject or ex vivo comprising administering the immunogenic composition to cells. Also disclosed is a method of synthesizing an immunostimulant comprising: identifying 2 or more different PAMPS, covalently linking the 2 or more different PAMPS together, varying spacing between the 2 or more different PAMPs, and testing the effect of spacing between the 2 or more different PAMPS to identify an optimal spacing that results in immune stimulation.