CAS: 1539-42-0; Bis(Pyridin-2-Ylmethyl)Amine

相似化合物

189440-33-3 2007916-80-3 25599-07-9

上下游产品

2-Cyanopyridine N,N-di(2-picolyl)-4-methylbenzenesulfonamide pyridine-2-carbaldehyde 2-(Aminomethyl)pyridine methyl 6-bromomethylnicotinate methyl 2-[bis-(2-pyridylmethyl)aminomethyl]pyridine-5-carboxylate 2,6-bis[bis(2-pyridylmethyl)aminomethyl]-4-methylphenol methyl>-4-methylphenol2-methyl-4-methylphenol

2-氰基吡啶置于氢气体系中,用 甲醇 用作溶剂,80.0 °C,3.0 Mpa 条件下,以93%的收率获得二甲基吡啶胺
参考文献:使用金属有机框架中的铱配合物通过腈的氢化均偶联选择性构建生物质基仲胺
标题:使用金属有机框架中的铱配合物通过腈的氢化均偶联选择性构建生物质基仲胺
摘要:最近研究了糠醛的还原胺化作为构建基于生物质的伯胺(糠胺)和叔胺[三(2-呋喃基甲基)胺]与仲胺[双(2-呋喃基甲基)胺]的直接方法由于选择性问题而成为问题.在这项研究中,我们展示了一种高度选择性和高效的策略来构建双(2-呋喃基甲基)胺通过 Ir 催化生物质基 2-呋喃甲腈一锅氢化自偶联得到 99% 的收率.Ir 催化剂是通过将 [cp*ir(Bpy)Cl]Cl 络合物固定在 2,2'-联吡啶官能化的 Uio-67 中制备的.相继检测到糠胺和糠胺衍生的仲亚胺作为中间体.详细的动力学分析表明仲亚胺氢化作为速率决定步骤而不是2-呋喃甲腈氢化.使用 Ir 催化剂,从相应的腈中选择性地制备出多种对称仲胺(18 个实施例),收率极佳至中等.
Doi:10.1021/acscatal.3C00831

专利信息

专利号:US-2021107859-A1
优先权日:2018-04-06
标题 :A process for the synthesis of carbon labeled organic compounds
发明人：AUDISIO DAVIDE; CANTAT THIBAULT; DESTRO GIANLUCA
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:A process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group is described. A method of using carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; a process for manufacturing labeled pharmaceuticals and agrochemicals comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; and a process for producing tracers comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure are also described.

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-2006051291-A1
优先权日:2004-09-07
标题 :Synthesis of radiolabeled sugar metal complexes
发明人：ADAM MICHAEL J; FISHER CARA L; BAYLY SIMON R; ORVIG CHRISTOPHER; LIM NATHANIEL C; STORR TIMOTHY J; EWART CHARLES B
权利人:ADAM MICHAEL J; FISHER CARA L; BAYLY SIMON R; ORVIG CHRISTOPHER; LIM NATHANIEL C; STORR TIMOTHY J; EWART CHARLES B
摘要:The invention provides a method for manufacturing or preparing neutral, low molecular weight 99m Tc-labeled and 186 Re-labeled carbohydrate complexes with an improved radiochemical yield from a simple functionalized sugar, such as glucosamine. In particular the synthesis relies on single ligand transfer (SLT) or double ligand transfer (DLT) reactions for converting a ferrocene compound into a rhenium or technetium tricarbonyl complex. The ferrocene compound may be linked to a sugar through various functional groups including, for example, thio, amino and alcohol functionalities to provide a wide range of radiolabeled sugar complexes that include both water soluble and relatively water insoluble compounds.

专利号:WO-2025045973-A1
优先权日:2023-08-31
标题 :Synthesis of lanifibranor intermediate
发明人：BOUBIA BENAÃ?SSA; GONZALEZ JÉRÔME; BELL FRÉDÉRIC
权利人:INVENTIVA
摘要:The present disclosure is directed to a process for preparing a compound of formula (I), which comprises a palladium-free coupling reaction between N-(4-chloro-2-iodo-phenyl)-1,3-benzothiazole-6-sulfonamide and methyl 5-hexynoate in the presence of a copper catalyst.

专利号:US-2023364251-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.

专利号:US-2010029911-A1
优先权日:2004-11-24
标题 :Method For Solid-Phase Peptide Synthesis And Purification
发明人：FRANK HANS-GEORG; CASARETTO MONIKA; KNORR KARSTEN
权利人:APLAGEN GMBH
摘要:Use of an activated solid phase and a peptide-conjugated anchoring part for solid phase peptide synthesis, wherein the anchoring part is coordinatively and reversibly attached to the activated solid phase.