CAS: 5680-80-8; H-Ser-Ome.Hcl

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CAS号67-56-1 甲醇 | CAS号56-45-1 L-丝氨酸 | CAS号111934-17-9 (2S)-methyl 2-(... | CAS号16428-75-4 L-丝氨酸盐酸盐 | CAS号75-36-5 乙酰氯 | CAS号96854-24-9 L-Serine, N-(me... | CAS号58861-77-1 4-Oxazolecarbox... | CAS号1258511-48-6 tert-butyl 1-({... | CAS号1258511-47-5 tert-butyl 1-({... | CAS号1065102-64-8 Methyl 2-(4-flu... | CAS号534-03-2 丝氨醇 | CAS号34290-59-0 b°C-phe-ser-ome | CAS号17136-54-8 S-3-氯丝氨酸甲酯盐酸盐 | CAS号2311-26-4 EDTADISODIUM | CAS号35356-70-8 2-乙酰胺基丙烯酸甲酯 | CAS号81629-69-8 methyl 2-(diace... | CAS号82911-78-2 fm°C-l-丝氨酸甲酯 | CAS号78715-83-0 (S)-(+)-4,5-二氢-... | CAS号88099-67-6 N,N-二苄基-L-丝氨酸甲酯

L-丝氨酸 以 水 作为反应溶剂,化学反应生成 L-丝氨酸甲酯盐酸盐
参考文献:Preparation And Isolation Of Mineral Acid Salt Of An Amino Acid Methyl
标题:Preparation And Isolation Of Mineral Acid Salt Of An Amino Acid Methyl
摘要:一种循环过程,用于从在甲醇中存在矿物酸的情况下,通过酯化氨基酸和甲醇产生的反应溶液中高纯度和高收率地生产和分离氨基酸甲酯的矿物酸盐,包括将产生的反应溶液冷却以沉淀矿物酸盐的晶体;过滤晶体;干燥分离的湿晶体或用另一种有机溶剂洗涤;并回收过滤液以在酯化反应中再次使用.

专利信息

专利号:US-9643915-B2
优先权日:2013-03-15
标题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-9708354-B2
优先权日:2013-03-15
标 题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-5801247-A
优先权日:1997-01-23
标题 :Process for the enantioselective synthesis of hydroxypyrrolidines from amino acids and products thereof
发明人：DALTON DAVID R; HUANG YIFANG
权利人:UNIV TEMPLE
摘要:The present invention relates to processes for the enantioselective synthesis of hydroxypyrrolidines from amino acids. An amino methyl ester is used as the starting material. The ester is reacted with a benziminoethyl ether to produce an oxazoline or thiazoline. Specifically, L-serine methyl ester is used to produce 4-(carbomethoxy)-2-phenyl-.increment. 2 -oxazoline, and cysteine is used to produce the corresponding thiazoline. The oxazoline (or thiazoline) can be reduced to an aldehyde by treatment with a slight excess of DIBAL-H. The oxazoline is quenched with alcohol and reacted with (carbomethoxymethylene)triphenylphosphorane, to produce (S)-(+)-methyl (E)- and (S)-(-)-methyl (Z)-3-(4,5-dihydro-2-phenyl-4-oxazolyl)-2-propenoate. The double bond is hydroxylated to yield the diol esters. The resulting diol is then treated with aqueous acid to hydrolyze the oxazoline and recyclize to produce 3,4-dihydroxy-5-hydroxymethylpyrrolidone benzoate. This is treated with an excess of borane in tetrahydrofuran to yield (2-hydroxymethyl) 3,4-dihydroxypyrrolidine. The intermediate compounds are useful both in the present process and as final products themselves. The total yield of the mixture of isomers, as well as their ratio, can be varied.

专利号:EP-1724260-B1
优先权日:2005-05-06
标题:Process for the synthesis of (2S, 3aR, 7aS)octahydroindole-2-carboxylic acid and its conversion to trandolapril
发明人：AKHTAR HAIDER; RAMESH BABU POTLURI; VENKATA SUBHRAMANIAN HARIHARAK; HARI PRASSAD KODALI
权利人:SOCHINAZ SA
摘要:The present invention describes a novel method for the synthesis of (2S,3aR,7aS)-octahydroindole-2-carboxylic acid of formula III nusing a new intermediate of formula II nand conversion of the product of formula-III to trandolapril of formula I

专利号:US-3855198-A
优先权日:1972-09-29
标 题:Novel intermediates for synthesis of l-(5-oxoprolyl)-l-histidy-l-tryptophyl-l-seryl-l-tyrosyl-l-glycyl-l-leucyl-l-arginyl-l-prolyl-glycine amide
发明人：SARANTAKIS D
权利人:AMERICAN HOME PROD
摘要:A process for the synthesis of LRF, i.e. L-(5-oxoprolyl)-Lhistidyl-L-tryptophyl-L-seryl-L-tyrosyl-glycyl-L-leucyl -Larginyl-L-prolyl-glycine amine by the classical route is described which comprises coupling a tetrapeptide, azide terminated, representing the 3-6 amino acid sequence in LRF with a C-amide terminated tetrapeptide representing the 7-10 amino acid sequence in LRF and thereafter converting the resulting octapeptide to LRF. Novel tetrapeptides and octapeptides useful as intermediates are described.

专利号:US-5350851-A
优先权日:1992-03-16
标题 :Intermediates and a process for synthesis of tetrahydropteridine C6-stereoisomers, including (6S)-tetrahydrofolate and N5-formyl-(6S)-tetrahydrofolate
发明人：BAILEY STEVEN W; AYLING JUNE E
权利人:UNIV SOUTH ALABAMA
摘要:Intermediates and a process for the synthesis of 6-monosubstituted tetrahydropteridine C6-stereoisomers, including (6S)-tetrahydrofolic acid. The intermediates are shown in their two enantiomeric forms as follows: ##STR1## wherein R 1 and R 2 are the same or different and represent hydrogen, methyl, hydroxy, amino, alkyl or dialkylamino, alkoxy, benzyloxy, or benzylthio; R 3 represents an alkene, alkyne, cycloalkyl, benzyl, alkyl (substituted with hydroxy, acetoxy, benzyloxy, alkoxy, alkylthio, amino, carboxy, oxo, or phosphate), a protected aldehyde, or ##STR2## wherein n=1 or 2, R 4 is hydrogen, formyl, methyl, or propargyl, and ZZ represents an amino acid or amino acid polymer.