CAS: 57981-02-9; O-(2,3,4,5,6-Pentafluorobenzyl)Hydroxylamine Hydrochloride For Gc Derivatization

2-((Perfluorophenyl)Methoxy)Isoindoline-1,3-Dione,正丁胺,盐酸,盐酸羟胺置于氮,Ice体系中,用 乙醇 作为反应溶剂,化学反应 1.0H,反应生成 邻-(2,3,4,5,6-五氟苄基)羟胺盐酸盐
参考文献:Insecticidal Oximes
标题:Insecticidal Oximes
摘要:通式(i)的化合物 ##str1## 其中r代表f,Cl,Br,I,乙氧基,甲氧基或丙氧基,N为1至5之间的整数;或r代表3,4-亚甲二氧基;r.Sup.1代表二氯甲基或三氯甲基.这些化合物具有节肢动物杀虫(特别是杀虫和杀螨)活性.

专利信息

专利号:EP-4424821-A1
优先权日:2023-03-01
标题:Enzymatic synthesis of odilorhabdin and related peptides/proteins comprising non-standard amino acid residues
权利人:MAX PLANCK GESELLSCHAFT
摘要:The present invention relates to a novel method of preparing a non-standard amino acid or a peptide/protein comprising a non-standard amino acid residue, as appropriate, wherein said amino acid residue is selected from 2,4-diamino-3-hydroxybutyrate, L-5-hydroxylysine, L-3-hydroxyarginine, 2,3-didehydroarginine by using enzymatic transformations. Accordingly, the present invention further relates to a method of preparing a peptide/protein comprising one or more non-standard amino acids selected from 2,4-diamino-3-hydroxybutyrate, L-5-hydroxylysine, L-3-hydroxyarginine and 2,3-didehydroarginine. The methods of the present invention are particularly useful in enzyme-assisted preparation of odilorhabdins and their derivatives. The present invention further relates to a polypeptide having 2,4-diaminobutyrate-3-hydroxylase activity and its use for catalyzing a hydroxylation at position 3 of 2,4-diaminobutyrate, to a polypeptide having having L-arginine 3-hydroxylase activity and its use for catalyzing a hydroxylation at position 5 of L-lysine, to a polypeptide having L-arginine 3-hydroxylase activity and its use for for catalyzing a hydroxylation at position 3 of L-arginine, and to a polypeptide having a deacylase activity, which is preferably capable of removing fatty acyl from the N-terminus of an odilorhabdin, and its use for catalyzing a deacylation, preferably for removing a fatty acyl from the N-terminus of an odilorhabdin.