CAS: 60-82-2; 3-(4-Hydroxyphenyl)-1-(2,4,6-Trihydroxyphenyl)Propan-1-One

相似化合物

3516-95-8 1088-08-0 23130-26-9

上下游产品

3,5-dihydroxyphenol 3-(p-hydroxyphenyl)propiononitrile 3-(4-acetoxyphenyl)propanenitrile 4'-(β-D-glucopyranosyloxy)-2',4",6'-trihydroxydihydr°Chalcone2'-hydroxy-4,4',6'-trimethoxydihydr°Chalcone 3,5-dihydroxyphenol 4-hydroxyphenylpropionic acid 4-hydroxy-benzoic acid

Phloridizin置于盐酸体系中,用 甲醇,水 作为反应溶剂,化学反应 3.0H,以85%的收率获得产物根皮素
参考文献:天然查耳酮在人类巨噬细胞中引发专门的促溶解介质和相关 15-脂氧合酶产物的形成
标题:天然查耳酮在人类巨噬细胞中引发专门的促溶解介质和相关 15-脂氧合酶产物的形成
摘要:专门的促分解介体 (Spm) 包括由多不饱和脂肪酸 (Pufa) 通过立体选择性氧化作用特别是涉及 12/15-脂氧合酶 (Lox) 产生的脂质介体 (Lm).与促炎 Lm(例如由 5-Lox 形成的白三烯和由环氧合酶形成的前列腺素)相比,Spm 具有抗炎和消炎特性.尽管糖皮质激素和阻止前列腺素产生的非甾体抗炎药 (Nsaid) 仍然是炎症相关疾病的主要治疗方法,尽管有严重的副作用,但新概念集中在 Spm 作为抗炎药物治疗的免疫溶解剂.在这里,我们研究了来自melodorum Fruticosum 的天然查耳酮 Mf-14 和相应的二氢查耳酮 Mf-15,用于调节人单核细胞来源的巨噬细胞中 Lm 的生物合成,包括白三烯,前列腺素,Spm 及其 12/15-Lox 衍生前体(Mdm) M1 和 M2 样表型.在受到金黄色葡萄球菌衍生的外毒素攻击的 Mdm 中,两种化合物 (10 µm) 均显着抑制
DOI:10.1016/j.Bcp.2021.114825

专利信息

专利号:US-5043328-A
优先权日:1986-05-09
标 题 :Formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems
发明人：WEITHMANN KLAUS U
权利人:HOECHST AG
摘要:The present invention relates to formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems and to the use of such formulations for the preparation of medicaments which are suitable for curing prostaglandin deficiencies in humans or animal, for example healing or preventing diseases of the gastro-intestinal tract.

专利号:US-2025235415-A1
优先权日:2022-02-23
标 题:Modulation of human breast milk composition
发明人：ROSS MICHAEL G; DESAI MINA
权利人:LUNDQUIST INST FOR BIOMEDICAL INNOVATION AT HARBOR UCLA MEDICAL CENTER
摘要:Compositions and methods for improving a child, such as an infant's health, are provided. The methods entail improving the quality of breast milk in a female human individual that provides breast milk, or expects to provide breast milk, to the child, by administering to the individual an agent that increases the individual's sensitivity to insulin, and/or an agent that reduces the substrate uptake, synthesis or secretion of long chain fatty acids, reduces the substrate uptake, synthesis or secretion of short chain fatty acids, increases the amino acid uptake, protein synthesis or protein secretion of proteins, or reduces the uptake or synthesis of lactose.

专利号:US-4113755-A
优先权日:1977-05-18
标题 :Synthesis of prostaglandin precursors
发明人：LAROCK RICHARD C
权利人:UNIV IOWA STATE RES FOUND
摘要:A process of making prostaglandin precursors by reacting bicyclic or polycyclic olefins with an alkenylmercuric salt, in the presence of a noble metal salt to provide a cis, beta-alkenyl bicyclic alkyl noble metal salt.

专利号:US-2019276389-A1
优先权日:2015-12-18
标题:Synthesis of aryl cyclohexane ester derivatives useful as sensates in consumer products
发明人：WOS JOHN AUGUST; YELM KENNETH EDWARD; BUNKE GREGORY MARK; FREDERICK HEATH ALAN; REILLY MICHAEL; HAUGHT JOHN CHRISTIAN; SREEKRISHNA KOTI TATACHAR; LIN YAKANG
权利人:PROCTER & GAMBLE
摘要:Personal care compositions, such as oral care and skin care compositions containing a flavor/perfume system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers.

专利号:US-2023266302-A1
优先权日:2020-07-24
标 题:Synthesis and use of n-benzyl sulfonamides
发明人：LAMAR ANGUS A; SHEAFF ROBERT J
权利人:THE UNIV OF TULSA
摘要:Disclosed is a method for preparing N-benzyl sulfonamides. Also disclosed is a composition for treating cancer. The composition includes a N-benzyl sulfonamide and a metabolic inhibitor. Also disclosed is a method for determining the impact on cell ATP levels of a composition containing a N-benzyl sulfonamide with or without a metabolic inhibitor.

专利号:US-2022228171-A1
优先权日:2019-07-17
标 题 :Compositions and production of nicked closed-ended dna vectors
发明人：ALKAN OZAN; KOTIN ROBERT MICHAEL; KERR DOUGLAS ANTHONY; MONDS RUSSELL; PELLETIER CAROLYN; STANTON MATTHEW
权利人:GENERATION BIO CO
摘要:The present application discloses methods for synthetic production and cell-free synthesis of DNA vectors, particularly closed-ended linear DNA vectors having one or more gaps (e.g., nicked ceDNA vectors, “neDNAâ€?) and adenoassociated-virus (AAV) vector which is single strand DNA having linear and continuous structure, for delivery and expression of a transgene in the host cell. The present invention also relates to an in vitro process for production of closed-ended DNA vectors, corresponding DNA vector products produced by the methods and uses thereof, and oligonucleotides and kits useful in the process of the present invention.