CAS: 60274-60-4; 1-Chloro-5-Iodopentane

该化合物是一种有机化合物,被归类为卤化氢,具体地说是一种主要烷酸盐,其分子式为C5H10ClI,表明五碳五色五色中子链中存在氯和碘替代物,其特点是有机溶剂中的沸点相对较低,溶解度中等,因此在各种化学反应中有用,特别是在核循环替代过程中.两种卤素的存在都具有独特的再活动模式,允许各种衍生物的潜在形成.1-Chroloo-5-iodopentane可以参与消除和替代等反应,使其在合成有机化学中具有价值.此外,其结构允许有立体化学考虑,因为卤素次组可能影响分子的空间安排.在处理这种化合物时,应当采取安全防范措施,因为氯和碘都是危险物质.

英文名称1-Chloro-5-Iodopentane
中文名称1-氯-5-碘戊烷
IUPAC名称1-chloro-5-iodopentane
其它别名1-Chloro-5-iodopentane; 1-Iodo-5-chloropentane; 5-Chloro-1-iodopentane
CAS编号60274-60-4
MFCD编号:MFCD00039416
EINECS号:262-137-4
FDA UNII编号:9R3MCR55RT
分子式:C5H10ClI
分子量:232.49
产品CID: 1579242
产品分类有机原料→分子砌块→脂肪链类化合物

相似结构搜索
产品信息参考;
InChIKey: GUUHKOCYWBEGGX-UHFFFAOYSA-N
InChI=1S/C5H10ClI/c6-4-2-1-3-5-7/h1-5H2…
计算化学: 氢键受体数0.0氢键供体数0可旋转键数4

相似化合物

34683-73-3 10297-05-9 2163-00-0

物理性质

沸点75-77 °C at 4 mmHg
闪点75-77 °C/4mm
密度1.663
PSA:0.0
LogP:2.8305
折射率1.5305
蒸汽压0.116 mmHg at 25 °C
溶解性Not Miscible Or Difficult To Mix With Water.
敏感性光敏感
外观形态透明无色液体
储存条件2-8°C(避光保存)
产品应用该化合物用于药物中间体.

MSDS等安全信息

GHS符号GHS07
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
UN编号NONH for all modes of transport
危险品标志Xi
安全声明26-36-37
危险类别码36/37/38
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

合成目标产物 1-Chloro-5-Iodopentane 主要起始原料 1,5-Pentanediol
(文献来源)合成步骤主要原料 1,5-Pentanediol

四氢吡喃置于氢氧化钾,三甲基氯硅烷,Sodium Iodide,Zinc(II) Chloride体系中,用甲醇,乙腈作为反应溶剂,化学反应 16.0H,反应生成 1-氯-5-碘戊烷
参考文献:中性水溶液中1-氯-4-碘丁烷的oh加合物向分子内自由基阳离子的转化
标题:中性水溶液中1-氯-4-碘丁烷的oh加合物向分子内自由基阳离子的转化
摘要:自由基与1-氯-4-碘丁烷在中性水溶液中反应形成的以碘为中心的oh加合物转变为(k = 5.4x10 5 S-1)成为分子内自由基阳离子(图选项).自由基与1-氯-5-碘戊烷反应反应生成的溶质自由基阳离子的结构不利,无法将oh加合物转化为分子内自由基,而是形成了二聚体自由基阳离子(图选项).
DOI:10.1016/s0009-2614(98)01370-0

海关参考信息

2903110000-一氯甲烷及氯乙烷
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-4026911-A
优先权日:1976-02-23
标题:Process for the preparation of ketoalkynoic acids and use of the process in an improved synthesis of 2-(substituted)-cyclo-pentane-1,3,4-triones
发明人：REVERMAN LAWRENCE FRANCIS
权利人:MILES LAB
摘要:Reaction of a 2-methyl-2-(alkenyl)-1,3-dioxolane with an Î±,Ï‰-dihalogenoalkane to obtain a 2-methyl-2-(Ï‰-chloroalkynyl)-dioxolane, conversion of the latter to a corresponding nitrile, and hydrolysis of the nitrile to form a ketoalkynoic acid is a novel process for preparing the acid. n Use of the process in the synthesis of 2-(substituted)-cyclopentane-1,3,4-triones improves that synthesis.

专利号:US-2009264648-A1
优先权日:2008-01-14
标题:Synthesis of pyrazoles
发明人：CHEW WARREN; WANG ZHENG; CHEAL GLORIA; BERTRAND MARTIAL; POTOSKI JOHN; MIRMEHRABI MAHMOUD; NENCINI ARIANNA; ZANALETTI RICCARDO
权利人:WYETH CORP; SIENA BIOTECH SPA
摘要:The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate Î±7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system.

专利号:WO-2009091832-A1
优先权日:2008-01-14
标题 :Synthesis of pyrazoles

专利号:WO-9506037-A1
优先权日:1993-08-27
标题 :New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor
发明人：VOLLINGA ROELANT CHRISTIAAN; MENGE WIRO MICHAEL PETRUS BERN; TIMMERMAN HENDRIK
权利人:VRIJE UNIVERSITEIT; VOLLINGA ROELANT CHRISTIAAN; MENGE WIRO MICHAEL PETRUS BERN; TIMMERMAN HENDRIK
摘要:The invention relates to new imidazole derivatives of formula (I) having agonistic and antagonistic activity on the histamine H3-receptor. More in particular the invention concerns 4- and 5-substituted aminoalkyl imidazoles and their derivatives. The invention further relates to the synthesis of these compounds, pharmaceutical compositions comprising the said compounds or pharmacological salts thereof, and the use of the compounds as agents having biological activity on the histamine H3-receptor or for the preparation of a pharmaceutical composition.

专利号:US-5268501-A
优先权日:1990-02-08
标题 :Process for preparing haloketo acid derivatives
发明人：IKEDA TAKAHARU; KAI SEIICHI; MINAI MASAYOSHI
权利人:SUMITOMO CHEMICAL CO
摘要:Process for preparing haloketo acid derivatives [I]: ##STR1## wherein R is H or C 1-6 alkyl, and X is chlorine or bromine, which comprises reacting Î²-oxo-acid ester [II]: ##STR2## wherein R 1 is H or C 1-6 alkyl, R 2 is C 1-5 alkyl or OR 3 (R 3 is C 1-6 alkyl), and X is the same as above, with nitrosating agent [IV]: n n ONOR.sup.4 [IV] n n wherein R 4 is H, alkyl, halogen or SO 3 H to give 7-halo-2-hydroxyminoheptanoic acid ester [III]: ##STR3## wherein R 1 and X are the same as above, following by reacting the product with aldehyde or ketone; and intermediates therefor, and process for preparing said intermediates. Said haloketo acid derivatives are useful as intermediate for synthesis of cilastatin, which is useful as medicament, especially as dehydropeptidase inhibitor.

专利号:DE-2707128-A1
优先权日:1976-02-23
标题:PROCESS FOR THE PREPARATION OF KETOALKYNIC ACIDS AND APPLICATION OF THE PROCESS TO AN IMPROVED SYNTHESIS OF 2- (SUBSTITUTE) -CYCLOPENTANE-1,3,4-TRIONEN