CAS: 619-89-6; 3-(4-Nitrophenyl)Acrylic Acid

该化合物是一种有机化合物,其特点是其芳香结构,其特点是一个硝基化合物组(-NO2)和一个附于一个碳酸基酸组(-COOH),通常看起来像一种黄色晶状固体,因其在各种化学反应和应用中的作用而闻名,包括作为有机合成和具有光性材料开发的前体;硝基辛酸组的存在增强了其反应力,使其在染料和药物合成中有用;4-硝基辛基酸显示有机溶剂中溶性中度和水中溶性有限,这在使用大型芳酸系统的化合物中很常见;其熔点和沸点可能因纯度和环境条件而不同;此外,它可以经历各种化学变异,例如减少和消毒化,使其成为有机化学的多元化合物;在处理该物质时,应当采取安全防范措施,因为如果浸入或吸入,可能会对健康造成危害.

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CAS号141-82-2 丙二酸 | CAS号555-16-8 对硝基苯甲醛 | CAS号79-10-7 丙烯酸 | CAS号586-78-7 对溴硝基苯 | CAS号27892-88-2 (E)-3-(4-nitrop... | CAS号64-19-7 冰醋酸 | CAS号1734-79-8 反式-4-硝基肉桂醛 | CAS号636-98-6 4-硝基碘苯 | CAS号557-34-6 醋酸锌 | CAS号100-00-5 对硝基氯苯 | CAS号100708-34-7 1-(3-iodopropyl... | CAS号501120-99-6 (R)-3-氨基-3-(4-硝... | CAS号949-99-5 4-硝基-L-苯丙氨酸 | CAS号18166-67-1 2-Propenamide,3... | CAS号555-16-8 对硝基苯甲醛 | CAS号298-12-4 乙醛酸 | CAS号64-18-6 甲酸 | CAS号3156-41-0 1-硝基,2-(4-硝基苯基)-乙烯 | CAS号953-26-4 4-硝基肉桂酸乙酯 | CAS号10342-64-0 1-(4-硝基苯基)乙酮肟

合成工艺路线路线简述

    P-Nitrocinnamonitrile置于磷酸体系中,用 水 作为反应溶剂,化学反应 2.0H,以92%的收率获得产物对硝基肉桂酸
    参考文献:Ep2157088
    标题:Ep2157088

    海关参考信息

    专利信息


    专利号:US-6765091-B1
    优先权日:1999-08-30
    标题:Oligosaccharides derived from ribose-ribitol-phosphate, and vaccines containing them
    发明人:BENCOMO VICENTE GUILLERMO VERE; ROY RENE
    权利人:UNIV LA HABANA; UNIV OTTAWA
    摘要:The present invention relates to the field of the Medicine, in particular with the chemical synthesis of oligosaccharide mixtures derived of ribose-ribitol-phosphate, which are used as active principle in vaccines for the prevention of infections caused by Haemophilus influenzae type b (Hib), as well as with the vaccines containing said oligosaccharide mixtures. n The oligasaccharide mixtures obtained by chemical synthesis of the present invention, comprise repeating units of formulae (phosphate-ribosa-ribitol)n or (ribose-ribitol-phosphate)n of at least 5 compounds of structure A or B, which represent the repeating unit of the capsular polysaccharide of Haemophilus influenzae type b and differ only by n, being n a value contained between 4 and 25 (n≧4 y≦25), and wherein R 1 or R 2 is a spacer for conjugation to a carrier, with the condition of R 1 =spacer if R 2 =H, or R 2 =spacer if R 1 =H. n The invention also is related with the immunogens containing such oligosaccharide mixtures, with the vaccines containing said immunogens and with the methods to prepare these oligosaccharides as mixtures. Furthermore, the invention includes the use of the vaccines, alone or combined with other vaccines, for the prevention of the infections caused by Haemophilus influenzae type b.

    专利号:US-5786448-A
    优先权日:1996-11-07
    标题:Combinatorial libraries of cyclic urea and cyclic thiourea derivatives and compounds therein
    发明人:NEFZI ADEL; OSTRESH JOHN M; HOUGHTEN RICHARD
    权利人:TREGA BIOSCIENCES INC
    摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of cyclic urea and cyclic thiourea compounds. The present invention further provides the compounds made by the combinatorial synthesis.

    专利号:US-6531470-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-2008214565-A1
    优先权日:2003-04-07
    标 题:Oxazolidinone Derivatives as Antimicrobials
    发明人:MEHTA ANITA; RUDRA SONALI; RAO AJJARAPU VENKATA SUBRAHMANYA RAJO; YADAV AJAY SINGH; RATTAN ASHOK
    权利人:MEHTA ANITA; RUDRA SONALI; RAO AJJARAPU VENKATA SUBRAHMANYA RAJO; YADAV AJAY SINGH; RATTAN ASHOK
    摘要:The present invention relates to certain substituted phenyl oxazolidinones of formula I and H and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

    专利号:US-10968162-B2
    优先权日:2018-03-30
    标 题:Method for the synthesis and purification of aryl acid esters
    发明人:MARSHALL JANET
    权利人:UNIV MIAMI
    摘要:The general inventive concepts are directed to the discovery that certain aryl acids can be esterified under particular conditions to provide the resulting ester as a solid that precipitates in good yield from the reaction mixture. The esters may then be isolated and purified with relative ease. Accordingly, a method for the esterification, isolation, and purification of aryl acids is provided.

    专利号:EP-4103640-B1
    优先权日:2020-02-11
    标 题 :New method of synthesis of chitosan derivatives and uses thereof
    发明人:KARGAPOLOV YURIY; FOMENKO VLADISLAV
    权利人:NOVOCHIZOL SA
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    主要参考文献

    [参考文献]: María L Salum, Et Al. Combined Experimental And Computational Investigation Of The Absorption Spectra Of E- And Z-Cinnamic Acids In Solution: The Peculiarity Of Z-Cinnamics. J Photochem Photobiol B. 2015 Jul:148:128-135.

    合成参考文献


    摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 356.
    摘要:Landelle, G.; Paquin, J.-F., Science of Synthesis Knowledge Updates, (2010) 4, 278.
    摘要:Kawęcki, R., Science of Synthesis Knowledge Updates, (2018) 4, 281.
    摘要:Bartsch, S.; Vogel, A., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 2, 302.
    摘要:Zhou, Q.-Q.; Wei, Y.; Lu, L.-Q.; Xiao, W.-J., Science of Synthesis: Photocatalysis in Organic Synthesis, (2018) 1, 173.
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