CAS: 6911-87-1; 4-Bromo-N-Methylaniline

该化合物是一种含有分子式C7H8BRN的溴化芳烃矿,该化合物的特点是在苯环上存在一个溴替代体和一个甲基氨基组,使其成为有机合成中有价值的中间体,其主要优点包括电益替代和混合反应中的高度回活动,便利其用于制备药品,农用化学品和特殊化学品.甲基氨基化合物组提高了有机溶解性,而溴混合物会通过Suzuki或Buchwald-Hartwig等交叉反应进一步发挥作用.该化合物通常作为具有高纯度的晶状固体供应,确保合成应用的一贯性能.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

N-methyl-N-nitrosoaniline N-acetyl-N-methylaniline bromoacetic acid dimethyl sulfate N-methyl-p-aminobenzoic acid N-(4-bromophenyl)-N-methylbenzamide 4-bromo-N-nitroso-N-methylaniline N-(4-bromo-phenyl)-N-methyl-N'-phenyl-ureaN-(4-bromo-phenyl)-N-methyl-N'-phenyl-urea

合成工艺路线路线简述

    N-甲基-N-亚硝基苯胺置于乙醚,乙醇,氢溴酸体系中,化学反应生成 4-溴-N-甲基苯胺
    参考文献:Fischer,O.,Chemische Berichte,1912,Vol. 45,P. 1100
    标题:Fischer,O.,Chemische Berichte,1912,Vol. 45,P. 1100

    专利信息


    专利号:WO-2015058868-A1
    优先权日:2013-10-25
    标题 :Compositions and methods for the treatment of cancer
    发明人:JIMENO DOÑAQUE JOSÉ Mª
    权利人:PANGAEA BIOTECH S L
    摘要:The invention relates to anti-tumor compounds which have been designed to functionally disrupt the cross-talk between AEG-1 and the p65 subunit of NF-κB. Therefore, the invention relates to methods and compositions for the treatment of cancer using the compounds identified in the present invention, as well as compositions adequate for sustained release of the compounds of the invention to be administered to the surgical site after resection of the tumor. The invention also provides methods for the synthesis of the compounds of the invention.

    专利号:KR-20220169970-A
    优先权日:2021-06-21
    标题 :Method for synthesis of aminobenzyne and multisubstituted organic nitrogen compounds using aza-brook rearrangement and multisubstituted organic nitrogen compounds prepared using the same

    专利号:CN-112169836-A
    优先权日:2020-09-28
    标 题:A kind of porous ionic polymer heterogeneous catalyst and method for catalyzing the synthesis of N-formamide

    专利号:US-2012009151-A1
    优先权日:2007-12-21
    标题 :Triazines And Related Compounds Having Antiviral Activity, Compositions And Methods Thereof
    发明人:HAN AMY QI; COBURN GLEN A; PROVONCHA KATHLEEN P; ROTSHTEYN YAKOV
    权利人:HAN AMY QI; COBURN GLEN A; PROVONCHA KATHLEEN P; ROTSHTEYN YAKOV; PROGENICS PHARM INC
    摘要:Disclosed herein are novel triazines and related compounds, the synthesis thereof, and compositions, including pharmaceutical compositions, comprising the novel triazines and related compounds. Such novel triazines and related compounds function to inhibit or block entry of viruses of the Flaviviridae family, including Hepatitis C virus (HCV), into cells that are susceptible to virus infection. These compounds are useful for the treatment, therapy and/or prophylaxis of viral diseases and infection, including HCV infection.

    专利号:US-6207836-B1
    优先权日:1993-02-17
    标 题 :Indolin-2-one derivatives
    发明人:ESAKI TORU; EMURA TAKASHI; HOSHINO EIICHI
    权利人:CHUGAI PHARMACEUTICAL CO LTD
    摘要:A compound represented by formula (I):wherein R1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a nitro group, a trifluoromethyl group, a lower alkylthio group, an acyl group, a carboxyl group, a mercapto group or an amino group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, an alkoxy group, an acyl group, an aryl group or a heterocyclic group; R3 represents a lower alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group; R4 represents a hydrogen atom, a lower alkyl group, an aryl group, a heterocyclic group, -OR5, -SR5 or -NR6R7 (wherein R5, R6, and R7 each represent a lower alkyl group, etc.); X and Y each represent -CH2-, -NH- or -O-; and n represents an integer of from 0 to 4, and an intermediate for synthesis thereof are disclosed. The compound of the present invention exhibits selective antagonism against gastrin receptors without causing side effects attributed to CCK-A receptor antagonism and is useful for the treatment and prevention of peptic ulcers, gastritis, reflux esophagitis, and Zollinger-Ellison syndrome, and for the treatment of neoplasm originating in the gastrointestinal system.

    专利号:CN-109836365-A
    优先权日:2019-01-15
    标题 :A class of amine thioacyl fluoride derivatives and synthesis method thereof
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    合成参考文献


    摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 182.
    摘要:Zhang, H.; Liu, C.; Lei, A., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 164.
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