CAS: 83-49-8; Hyodeoxycholic Acid

上下游产品

3α,6α-diacetoxy-12-oxo-5β-cholan-24-oic acid ethyl ester 6-Ketolith°Cholic acid 3,6-diox°Cholanoic acid 7,7-ethanediyldimercapto-3α,6α-dihydroxy-5β-cholan-24-oic acidethyl hyodeoxycholate Progesterone Pregnenolone 3β-hydroxy-5-cholenoic acid

3α-羟基-7-氧代-5β-胆烷酸置于吡啶,盐酸,氢氧化钾,乙醇,Boron Fluoride Ether,氢溴酸,溴,镍,溶剂黄146体系中,化学反应生成 猪去氧胆酸
参考文献:Hsia Et Al.,Journal Of Biological Chemistry,1957,Vol. 225,P. 811,818
标题:Hsia Et Al.,Journal Of Biological Chemistry,1957,Vol. 225,P. 811,818

专利信息

专利号:US-4351767-A
优先权日:1981-06-29
标题 :Synthesis of 24,25-dihydroxycholesterol
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:This invention relates to the synthesis of steroids which are useful for their biological activity or which may be converted to steroids which have such activity. More particularly, the invention pertains to the synthesis of 24,25-dihydroxycholesterol. It includes intermediate sterols of this synthesis and processes for their preparation.

专利号:US-4174345-A
优先权日:1978-08-01
标题:Synthesis of steroids
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:In the synthesis of sterols wherein methoxyethoxymethyl groups in an ether linkage are attached to the nucleus of the sterol to protect the sterol nucleus during other steps of the synthesis and the sterols are thereafter treated to remove the methoxyethoxymethyl groups and set free the hydroxyl groups, the improvement in which the sterols being treated with zinc bromide are held in a methylene chloride solution containing a small amount of an aliphatic alcohol having from 1 to 6 carbon atoms.

专利号:US-4226770-A
优先权日:1978-02-10
标题:Synthesis of steroids
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:The synthesis of 1α,25-dihydroxycholesterol, 1α,25-dihydroxy-7-dehydrocholesterol and 1α,25-dihydroxycholecalciferol and other sterol derivatives from bile acids. Also the synthesis of 3,6-diketo steroids useful in the production of 1α,25-dihydroxycholesterol and other sterols which are biologically active or can be converted to biologically active sterols. The invention involves the sterols so produced and the processes by which they are prepared.

专利号:US-4354972-A
优先权日:1981-06-29
标 题 :Synthesis of steroids
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:This invention relates to the synthesis of steroids which are useful for their biological activity or which may be converted to steroids which have such activity. These syntheses include the steroid compounds and processes for their preparation. n An object of the invention is to provide syntheses which are applicable to materials which are readily available in good supply for converting such materials to steroids which are useful and desirable in the manufacture of pharmaceutical products. n More particularly, I have sought to discover processes and intermediate compounds useful in the synthesis of 24, 25-dihydroxycholesterol from hyodeoxycholic acid or lithocholic acid which are constituents of, and readily available from, animal bile.

专利号:US-4163744-A
优先权日:1978-02-10
标 题:Synthesis of steroids
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:The synthesis of 1α,25-dihydroxycholesterol, 1α,25-dihydroxy-7-dehydrocholesterol and 1α,25-dihydroxycholecalciferol and other sterol derivatives from bile acids. Also the synthesis of 3,6-diketo steroids useful in the production of 1α,25-dihydroxycholesterol and other sterols which are biologically active or can be converted to biologically active sterols. The invention involves the sterols so produced and the processes by which they are prepared.

专利号:US-4217279-A
优先权日:1978-12-18
标 题 :Synthesis of steroids
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:The synthesis of 25-hydroxycholesterol and 1α,25-dihydroxycholesterol in which the sterol nucleus of an ester of hyodeoxycholic acid is stabilized by protection of the 3 and 6α-hydroxyl groups with alkyl groups, alkyl ether groups, preferably with the 3β-methoxyethoxymethyl group or with the heterocyclic 2-tetrahydropyran group, then extending the chain from the carbon at the 24-position to a cyanide group at the 25-position and then subjecting the sterol so formed to a series of reactions by which it is transformed into 1α,25-dihydroxycholesterol or by a modified series of reactions to 25-hydroxycholesterol.