CAS: 99295-82-6; H-Cpa-Oh

相似化合物

96539-87-6 371770-32-0 143415-31-0

环戊烷三氟硼酸钾,L-丝氨酸置于rhodamine B,î²-Subunit Pyridoxal 5'-Phosphate Enzyme,Tryptophan Synthase From Pyrococcus Furiosus,E104G Mutant体系中,用 Aq. Phosphate Buffer 作为反应溶剂,以36%的收率获得产物
参考文献:协同光氧化还原-吡哆醛自由基生物催化立体选择性氨基酸合成
标题:协同光氧化还原-吡哆醛自由基生物催化立体选择性氨基酸合成
摘要:开发生物化学和有机化学中未知的合成有用的酶反应是生物催化中的一个重要挑战.通过光氧化还原催化和吡哆醛5'-磷酸(plp)生物催化的协同合并,我们开发了一种吡哆醛自由基生物催化方法来制备有价值的非经典氨基酸,包括那些带有立体化学二联体或三联体的氨基酸,而无需保护基团.使用工程化 Plp 酶,可以通过生物催化剂控制的方式生产任一对映体产物.协同光氧化还原-吡哆醛自由基生物催化代表了一个强大的平台,通过它可以发现以前未知的催化反应并驯服用于不对称催化的自由基中间体.
DOI:10.1126/science.Adg2420

专利信息

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-7091313-B2
优先权日:1999-08-30
标 题:Synthesis of template-fixed β-hairpin loop mimetics
发明人：ROBINSON JOHN A; OBRECHT DANIEL
权利人:POLYPHOR AG
摘要:Template-fixed β-hairpin loop mimetics comprising a template corresponding to one of the structures (a), (b), (c), (d), (e), (f), (g), (h) and a template-fixed chain of 4 to 20 α-amino acid residues which, if their α-C atom is asymmetric, have L-configuration can be manufactured by a novel process which is based on a mixed solid- and solution phase synthetic strategy. If desired, this process can be modified to give the enantiomers of these template-fixed β-hairpin loop mimetics. These enantiomers are novel compounds, and many of said template-fixed β-hairpin loop mimetics themselves are also novel compounds. The template-fixed β-hairpin loop mimetics and their enantiomers can mimic flat surfaces of proteins and thus be used to probe large surface protein-protein interactions. Accordingly they can serve as lead finding tools for protein targets where it is difficult to find small-molecular-weight lead compounds.

专利号:WO-2021130756-A1
优先权日:2019-12-25
标题:Combinations of non-protein amino acids and acetolactate synthase enzyme inhibitors
发明人：KLIPCAN LIRON; VAN-OSS PINHASI RUTH
权利人:THE STATE OF ISRAEL MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT AGRICULTURAL RES ORGANIZATION ARO VO
摘要:The present invention provides compositions and methods for disrupting protein synthesis in plant cells.

专利号:US-2018371021-A1
优先权日:2017-05-11
标 题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-11091522-B2
优先权日:2018-07-23
标题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2005181454-A1
优先权日:1999-08-30
标 题 :Synthesis of template-fixed beta-hairpin loop mimetics