CAS: 1166-52-5; Dodecyl 3,4,5-Trihydroxybenzoate

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CAS号112-53-8 月桂醇 | CAS号149-91-7 没食子酸; 3,4,5-三羟基苯甲酸 | CAS号1063201-08-0 dodecyl 3,4,5-t... | CAS号35388-10-4 3,4,5-trihydrox...

没食子酸置于4-二甲氨基吡啶,Hydrazine Hydrate,三乙胺,N,N'-二环己基碳二亚胺体系中,用 乙醇,N,N-二甲基甲酰胺,甲苯 用作溶剂,化学反应 6.5H,反应生成没食子酸月桂酯
参考文献:用没食子酸和十二烷基双子链开发用于水包油乳液的双子界面抗氧化剂.
标题:用没食子酸和十二烷基双子链开发用于水包油乳液的双子界面抗氧化剂.
摘要:在这项研究中,通过使用预填充柱和蠕动泵为基础的纯化系统,通过使用没食子酸和十二烷基双基尼链的steglich酯化,开发了用于水包油(o / W)乳液的双基没食子酸酯(gg)界面抗氧化剂.制备的gg和单没食子酸酯(mg)的结构特征和纯度通过NMR,傅里叶变换红外光谱和高效液相色谱-质谱法得到证实.进一步的评价表明,相对于mg,Gg在o / W乳液中具有优异的自由基清除活性和优异的抗氧化活性,尤其是在乳化剂的量减少的条件下.通过荧光探针和透射电子显微镜(tem)进行的显微镜研究表明,由于独特的双子分子结构,O / W乳液中出色的抗氧化性能可能归因于优选的界面位置.双子抗氧化剂的优异抗氧化活性为o / W乳液中的抗氧化提供了广阔前景.
Doi:10.1021/acs.Jafc.0C00807

专利信息

专利号:EP-2354120-A1
优先权日:2003-08-20
标题 :Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; YAO FENMEI; LUDWIKOW MARIA J; PHAN THU; PENG GE
权利人:XENOPORT INC
摘要:The present invention relates to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-tluorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The present invention also relates to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.

专利号:US-11273138-B2
优先权日:2017-11-02
标 题 :Use of amino acid supplementation for improved muscle protein synthesis
发明人：WOLFE ROBERT R; FERRANDO ARNY
权利人:BIOVENTURES LLC
摘要:The present invention encompasses an amino acid composition for stimulating muscle protein synthesis. Further, the present disclosure relates generally to the use of an anabolic amino acid composition for the stimulation of muscle protein synthesis. In particular, disclosed are compositions and methods of using the same for the prevention and/or treatment of a loss of any one of muscle mass, muscle strength, muscle function, and physical function, or any combination thereof, in a mammal, especially an adult mammal. Also provided are kits comprising a composition for the stimulation of muscle protein synthesis and, in certain embodiments, instructions for administration.

专利号:US-8372881-B2
优先权日:2005-06-20
标题 :Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use
发明人：ZERANGUE NOA; JANDELEIT BERND; LI YUNXIAO; GALLOP MARK A
权利人:XENOPORT INC; ZERANGUE NOA; JANDELEIT BERND; LI YUNXIAO; GALLOP MARK A
摘要:Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid, pharmaceutical compositions thereof, methods of making prodrugs of trans-4-(aminomethyl)-cyclohexane-carboxylic acid, and methods of using prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid and pharmaceutical compositions thereof to treat or prevent various diseases or disorders are disclosed. Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid and pharmaceutical compositions thereof suitable for oral and topical administration and for administration using sustained release dosage forms are also disclosed.

专利号:US-7749985-B2
优先权日:2006-09-15
标 题 :Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
发明人：GALLOP MARK A; XU FENG; PHAN THU; DILIP USHA; PENG GE
权利人:XENOPORT INC
摘要:Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.

专利号:US-7935686-B2
优先权日:2004-11-03
标 题 :Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use
发明人：GALLOP MARK A
权利人:XENOPORT INC
摘要:Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous acid, 3-aminopropylphosphinic acid, and analogs thereof, pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous acid, 3-aminopropylphosphinic acid, and analogs thereof, methods of making prodrugs of 3-aminopropylphosphonous acid, 3-aminopropylphosphinic acid, and analogs thereof, methods of using prodrugs of 3-aminopropylphosphonous acid, 3-aminopropylphosphinic acid, and analogs thereof and pharmaceutical compositions thereof for treating or preventing diseases or disorders such as spasticity or gastroesophageal reflux disease are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous acid, 3-aminopropylphosphinic acid, and analogs thereof and sustained release oral dosage forms thereof, which are suitable for oral administration, are also disclosed.

专利号:US-10100088-B2
优先权日:2014-03-17
标题:Glycopeptide derivatives for the preservation and protection of biological materials and microorganisms
发明人：DELIENCOURT-GODEFROY GERALDINE; MARTIN THIBAUT
权利人:TFCHEM
摘要:The present invention relates to a compound of the following formula (I): n nin which at least one and only one group chosen among R 5 , R 6 and R 7 is a group of the following formula:n n n n n n n n n n n The present invention relates also to uses thereof for preservation and/or protection and/or regeneration of biological materials and or microorganisms and for cosmetic or dermatological applications such as anti-aging, skin protection and skin regeneration; to culture, storage and/or preservation media comprising such a compound; to cosmetic or dermatological compositions comprising such a compound; to processes for preparing such a compound; and to synthesis intermediates.