CAS: 1208319-26-9; N-Methyl-1-(Trans-4-(Methyl(7H-Pyrrolo[2,3-D]Pyrimidin-4-yl)Amino)Cyclohexyl)Methanesulfonamide

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-2023119606-A1
优先权日:2020-02-18
标 题:Immune cell modulators
发明人：SHERDEN NATHANIEL; YU SHEN; STONER ISAAC
权利人:OCTAGON THERAPEUTICS INC
摘要:Disclosed are immune cell-selective small molecule compounds that modulate certain immune cell-specific receptors and enzymes, and methods of their synthesis and use to treat proliferative disorders.

专利号:CN-114605420-B
优先权日:2022-04-25
标 题 :Synthesis method of oclacitinib maleate

专利号:CN-116897156-A
优先权日:2020-09-08
标题:Novel JAK inhibitor compounds, methods of synthesis and uses thereof

专利号:CN-116917285-A
优先权日:2020-09-11
标题 :Novel JAK inhibitor compounds, methods of synthesis and uses thereof

专利号:AU-2004227362-B2
优先权日:2003-04-01
标题:Acyl- phosphate and phosphonate probes and methods of their synthesis and use in proteomic analysis