1017-89-6 = 1499-21-4 + 1079-66-9 + 813-77-4 + 3743-07-5 [标题:Reaction Conditions 标题:Reaction Of Chlorophosphoranes With Trialkyl Phosphites 作者:Gazizov,M. B.; Et Al 参考文献:Zhurnal Obshchei Khimii 日期:1986 卷标:56(7) 页码:1659-60
苯基二氯化磷置于氧气体系中,用 甲苯 用作溶剂,化学反应 4.0H,以93%的收率获得二苯基次膦酰氯 参考文献:Ramage,Robert; Atrash,Butrus; Hopton,David,Journal Of The Chemical Society. Perkin Transactions I,1985,P. 1217-1226 标题:Ramage,Robert; Atrash,Butrus; Hopton,David,Journal Of The Chemical Society. Perkin Transactions I,1985,P. 1217-1226
专利号:US-2012178710-A1 优先权日:2009-07-01 标题 :Synthesis of cyclic diguanosine monophosphate and thiophosphate analogs thereof 发明人:JONES ROGER A; GAFFNEY BARBARA L 权利人:JONES ROGER A; GAFFNEY BARBARA L; UNIV RUTGERS 摘要:The invention provides methods for the synthesis of cyclic dinucleotides and thiophosphate analogs thereof as well as a new family of analogs of cyclic diguanosine monophosphate that includes a series of seven phosphorothioate derivatives that includes diastereomers of mono-, di-, and trithiophosphates.
专利号:US-11708341-B2 优先权日:2016-08-05 标题:Synthesis of (S)-2-amino-4-methyl-((R)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof 发明人:Beaver Matthew; CUI SHENG; SHI XIANGQING 权利人:AMGEN INC 摘要:The present invention provides new methods for preparing compound 5, and pharmaceutically acceptable salts thereof, of structure n nCompound 5, or a pharmaceutically acceptable salt thereof, is an important intermediate in the synthesis of carfilzomib. The invention further provides methods of making a useful manganese catalyst that may be used in the epoxidation step of the present invention.
专利号:US-6875866-B2 优先权日:2002-02-21 标题:Process for synthesis of D1 receptor antagonists 发明人:DAHANUKAR VILAS H; ECKERT JEFFREY M; GALA DINESH; LUCAS BRIAN; SCHUMACHER DORIS P; ZAVIALOV ILIA 权利人:SCHERING CORP 摘要:In one embodiment, the present invention describes the synthesis of a compound of formula n n nand intermediates therefor.
专利号:US-6818773-B2 优先权日:2001-10-15 标题:Synthesis of 4-[(Z)-4-bromophenyl)(ethoxyimino) methyl]-1'-[(2,4-dimethyl-1-oxido-3-pyridinyl)carbony)]-4'-methyl-1,4-′bipiperidine 发明人:CHEN MINZHANG; D SA BOSCO ANTHONY; LEONG WILLIAM W; GAN TONG; WONG GEORGE S K; TANG SUHAN; NIELSEN CHRISTOPHER MICHAEL 权利人:SCHERING CORP 摘要:In one embodiment, the present invention describes the synthesis of 4-[(Z)-(4-bromophenyl)(ethoxyimino)methyl]-1'-[(2,4-dimethyl-1-oxido-3-pyridinyl)carbonyl]-4'-methyl-1,4'-bipiperidine, and intermediates therefor from easily available starting materials by a simple route.
专利号:US-10851130-B2 优先权日:2018-01-29 标题:Chemical synthesis method of Plesiomonas shigelloides serotype O51 O-antigen oligosaccharide 发明人:YIN JIAN; HU JING; SEEBERGER PETER; QIN CHUNJUN 权利人:UNIV JIANGNAN; MAX PLANCK INST OF COLLOIDS AND INTERFACES 摘要:The present disclosure discloses the chemical synthesis method of the Plesiomonas shigelloides serotype O51 O-antigen oligosaccharide, belonging to the field of chemistry. Source-abundant D-glucose, L-fucose, D-glucosamine and the like are used as raw materials to prepare three glycosylation building blocks, the synthetic route composed of 11 reaction modules is designed, and through the optimization of protecting group and the optimization of the time of introducing functional group, the preparation of the target oligosaccharide chain is successfully achieved. The oligosaccharide chain prepared in the present disclosure has the advantages of cheap and easy-to-get raw materials, and simple and easy-to-repeat preparation method. The present disclosure will have good application prospects in the aspects of development of new drugs and vaccines of Plesiomonas shigelloides , and the like.
专利号:US-7976824-B2 优先权日:2003-07-31 标题:Production of 2-18F-2-deoxy-D-glucose via solid-phase synthesis 发明人:BROWN LYNDA JANE; BROWN RICHARD CHARLES DOWNIE; WADSWORTH HARRY JOHN; JACKSON ALEXANDER 权利人:GE HEALTHCARE LTD 摘要:The invention relates to a compound of formula (I): wherein P 1 , P 2 , P 3 , and P 4 are each independently hydrogen or a protecting group; and n is an integer of from 2 to 20 and to the use of such compounds for the synthesis of 18 F-FDG.