CAS: 17739-45-6; 2-(2-Bromoethoxy)Tetrahydro-2H-Pyran

该化合物是一种溴化醚衍生物,含有一种四氢环(oxane),与溴环氧替代物相连,该化合物主要用作有机合成的中间体,特别是用于通过核循环替代反应制备复杂的分子.溴环氧组的存在可增强再活性,促成高效的烷基或醚化过程.它的氧环有助于稳定性,适合在不同条件下的受控反应.该化合物通常用于用于用于建造异环化框架的制药和农用化学研究.由于它具有潜在的色素和刺激特性,需要妥善处理.建议在惰性条件下储存以稳定性.

结构式图片

相似化合物

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合成工艺路线路线简述

    2-溴乙醇置于对甲苯磺酸,3,4-二氢-2H-吡喃体系中,用 二氯甲烷 用作溶剂,化学反应 16.17H,以70%的收率获得2-(2-溴乙氧基)四氢吡喃
    参考文献: Lipid Compounds And Lipid Nanoparticle Compositions[fr] Composés Lipidiques Et Compositions De Nanoparticules Lipidiques
    标题: Lipid Compounds And Lipid Nanoparticle Compositions[fr] Composés Lipidiques Et Compositions De Nanoparticules Lipidiques
    摘要:本文提供了一种脂质化合物,可与其他脂质成分(如中性脂质,胆固醇和聚合物共轭脂质)结合使用,形成脂质纳米粒子,用于传递治疗剂(如核酸分子)以进行治疗或预防,包括疫苗接种.本文还提供了包含所述脂质化合物的脂质纳米粒子组合物.

    海关参考信息

    专利信息


    专利号:US-7390926-B2
    优先权日:2006-03-27
    标 题:Process for the diastereoselective alkylation of an ether oxime of the compound nopinone and novel intermediates for the synthesis of diastereospecific 2-amino-nopinone derivatives substituted on carbon 3
    发明人:CAILLE JEAN-CLAUDE; MAUDUIT MARC
    权利人:ZACH SYSTEM
    摘要:The invention provides the diastereoselective alkylation of optically active nopinone to form the compound of formula (I) according to scheme A below: n nin which:n —R is a C 5-15 alkyl group; —R1 is especially a C 1-15 alkyl, C 2-15 alkenyl or C 2-15 alkynyl group or a C 5-15 aryl, each group optionally being substituted; and —X is a halogen atom; and the configuration of the compound of formula (I) is either (E) or (Z) or a mixture of the two. nn The compound of formula (I) is a valuable synthetic intermediate.

    专利号:US-7402670-B2
    优先权日:2004-09-30
    标 题:Synthesis by chiral diamine-mediated asymmetric alkylation
    发明人:DENG XIAOHU; MANI NEELAKANDHA
    权利人:JANSSEN PHARMACEUTICA NV
    摘要:Chiral synthesis from an achiral starting material by chiral diamine-mediated, such as sparteine-mediated, intermolecular asymmetric alkylation with a strained cyclic ether in the presence of a Lewis acid.

    专利号:US-2007225516-A1
    优先权日:2006-03-27
    标题:Process for the diastereoselective alkylation of an ether oxime of the compound nopinone and novel intermediates for the synthesis of diastereospecific 2-amino-nopinone derivatives substituted on carbon 3

    专利号:US-2011124634-A1
    优先权日:2008-05-13
    标 题:Bioactive compounds for treatment of cancer and neurodegenerative diseases
    发明人:SUN CONNIE L; LI XIAOYUAN
    权利人:PONIARD PHARMACEUTICALS INC
    摘要:The invention provides bioactive compounds for the treatment of various malconditions such as cancer and neurodegenerative diseases including Alzheimer's disease. The chemical compounds as disclosed herein are found to show bioactivity in bioassays related to these conditions. Pharmaceutical compositions, combinations and methods of synthesis are provided, as are methods of using the compound, compositions and combinations in the treatment of the diseases.

    专利号:WO-2007110548-A1
    优先权日:2006-03-27
    标题 :Process for diastereoselective alkylation of the oxime ether of the compound nopinone, and new intermediates for the synthesis of diastereospecific 2-amino-nopinone derivatives substituted on the 3 carbon

    专利号:US-6465142-B1
    优先权日:1996-04-30
    标 题 :Low-temperature cure polyvinylbutyral as a photoconducter binder
    发明人:NGUYEN KHE C; GANAPATHIAPPAN SIVAPACKIA
    权利人:HEWLETT PACKARD CO
    摘要:Poly(vinyl butyral) compounds of Formula 1whereR1 is alkyl, dialkyl ether, alkyl carbonyl, cycloalkyl, cycloalkyl alkyl, aryl, aryl carbonyl, alkaryl carbonyl, aralkyl, or alkyl aralkyl;Z is -OH or -NHR2, where R2 is independently alkyl, dialkyl ether, alkyl carbonyl, cycloalkyl, cycloalkyl alkyl, aryl, aryl carbonyl, alkaryl carbonyl, aralkyl, alkyl, aralkyl or R2 is H.x is 60 to 95 mol %, y is 3 to 40 mol %, z is 0 to 20 mol %; andx+y+z is 100 mol %, a process for preparing compounds of Formula I, an intermediate in the synthesis of compounds of Formula I, and a photoconductor for electrophotography containing a compound of Formula I as a binder in the charge generation layer are described. These compounds can be crosslinked in the absence of strong acidic and basic catalyst at relatively low temperatures compared with conventional polyvinyl butyral, show good adhesion to a wide variety of surfaces, and exhibit high photoresponses when used in charge generation layers of photoconductors.
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    主要参考文献

    [参考文献]: Hitomi Uchimoto, Et Al. Preparation Of Chiral Ligands Connected With Quaternary Ammonium Group For Recyclable Catalytic Asymmetric Transfer Hydrogenation In Ionic Liquid. Chem Pharm Bull (Tokyo). 2015;63(3):200-9.
    [参考文献]: Y Endo, Et Al. Potent Estrogen Agonists Based On Carborane As A Hydrophobic Skeletal Structure. A New Medicinal Application Of Boron Clusters. Chem Biol. 2001 Apr;8(4):341-55.
    [参考文献]: Zhihao Zha, Et Al. Multidentate (18)F-Polypegylated Styrylpyridines As Imaging Agents For Aβ Plaques In Cerebral Amyloid Angiopathy (Caa). J Med Chem. 2011 Dec 8;54(23):8085-98.

    合成参考文献


    摘要:Molander, G. A.; Beaumard, F., Science of Synthesis Knowledge Updates, (2013) 3, 131.
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