专利号:US-7390926-B2 优先权日:2006-03-27 标 题:Process for the diastereoselective alkylation of an ether oxime of the compound nopinone and novel intermediates for the synthesis of diastereospecific 2-amino-nopinone derivatives substituted on carbon 3 发明人:CAILLE JEAN-CLAUDE; MAUDUIT MARC 权利人:ZACH SYSTEM 摘要:The invention provides the diastereoselective alkylation of optically active nopinone to form the compound of formula (I) according to scheme A below: n nin which:n —R is a C 5-15 alkyl group; —R1 is especially a C 1-15 alkyl, C 2-15 alkenyl or C 2-15 alkynyl group or a C 5-15 aryl, each group optionally being substituted; and —X is a halogen atom; and the configuration of the compound of formula (I) is either (E) or (Z) or a mixture of the two. nn The compound of formula (I) is a valuable synthetic intermediate.
专利号:US-7402670-B2 优先权日:2004-09-30 标 题:Synthesis by chiral diamine-mediated asymmetric alkylation 发明人:DENG XIAOHU; MANI NEELAKANDHA 权利人:JANSSEN PHARMACEUTICA NV 摘要:Chiral synthesis from an achiral starting material by chiral diamine-mediated, such as sparteine-mediated, intermolecular asymmetric alkylation with a strained cyclic ether in the presence of a Lewis acid.
专利号:US-2007225516-A1 优先权日:2006-03-27 标题:Process for the diastereoselective alkylation of an ether oxime of the compound nopinone and novel intermediates for the synthesis of diastereospecific 2-amino-nopinone derivatives substituted on carbon 3
专利号:US-2011124634-A1 优先权日:2008-05-13 标 题:Bioactive compounds for treatment of cancer and neurodegenerative diseases 发明人:SUN CONNIE L; LI XIAOYUAN 权利人:PONIARD PHARMACEUTICALS INC 摘要:The invention provides bioactive compounds for the treatment of various malconditions such as cancer and neurodegenerative diseases including Alzheimer's disease. The chemical compounds as disclosed herein are found to show bioactivity in bioassays related to these conditions. Pharmaceutical compositions, combinations and methods of synthesis are provided, as are methods of using the compound, compositions and combinations in the treatment of the diseases.
专利号:WO-2007110548-A1 优先权日:2006-03-27 标题 :Process for diastereoselective alkylation of the oxime ether of the compound nopinone, and new intermediates for the synthesis of diastereospecific 2-amino-nopinone derivatives substituted on the 3 carbon
专利号:US-6465142-B1 优先权日:1996-04-30 标 题 :Low-temperature cure polyvinylbutyral as a photoconducter binder 发明人:NGUYEN KHE C; GANAPATHIAPPAN SIVAPACKIA 权利人:HEWLETT PACKARD CO 摘要:Poly(vinyl butyral) compounds of Formula 1whereR1 is alkyl, dialkyl ether, alkyl carbonyl, cycloalkyl, cycloalkyl alkyl, aryl, aryl carbonyl, alkaryl carbonyl, aralkyl, or alkyl aralkyl;Z is -OH or -NHR2, where R2 is independently alkyl, dialkyl ether, alkyl carbonyl, cycloalkyl, cycloalkyl alkyl, aryl, aryl carbonyl, alkaryl carbonyl, aralkyl, alkyl, aralkyl or R2 is H.x is 60 to 95 mol %, y is 3 to 40 mol %, z is 0 to 20 mol %; andx+y+z is 100 mol %, a process for preparing compounds of Formula I, an intermediate in the synthesis of compounds of Formula I, and a photoconductor for electrophotography containing a compound of Formula I as a binder in the charge generation layer are described. These compounds can be crosslinked in the absence of strong acidic and basic catalyst at relatively low temperatures compared with conventional polyvinyl butyral, show good adhesion to a wide variety of surfaces, and exhibit high photoresponses when used in charge generation layers of photoconductors.
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合成参考文献
摘要:Molander, G. A.; Beaumard, F., Science of Synthesis Knowledge Updates, (2013) 3, 131.