CAS: 300543-56-0; (R)-1-((4-Chlorophenyl)(Phenyl)Methyl)Piperazine

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(R)-4-Methoxyphenyl 4-((4-Chlorophenyl)(Phenyl)Methyl)Piperazine-1-Carboxylate置于sodium Hydroxide,水体系中,用 异丙醇 用作溶剂,化学反应 2.75H,反应生成(-)-1-[(4-氯苯基)苯甲基]哌嗪
参考文献:Process For Making N-(Diphenylmethyl)Piperazines
标题:Process For Making N-(Diphenylmethyl)Piperazines
摘要:公式(8)的化合物,无论是消旋体还是单对映体形式,对制备n-(二苯甲基)-哌嗪类化合物如西替利嗪和左西替利嗪很有用. 其中z最好是苯基.

专利信息

专利号:US-2010145049-A1
优先权日:2008-11-21
标 题 :Process for making n-(diphenylmethyl)piperazines
发明人：ZHU JIE; FIRET JUDITH JANNEKE
权利人:ZHU JIE; FIRET JUDITH JANNEKE
摘要:A compound of formula (8) or a salt thereof: n n n n n n n n n n wherein Z represents a group containing 1-20 carbon atoms and at least one chiral carbon atom and having a single conformation, is useful in the synthesis of pharmaceutical compounds, especially chiral compounds such as levocetirizine.