CAS: 3768-18-1; N-Acetylcytidine

相似化合物

113886-71-8 401812-97-3 10578-79-7

上下游产品

CAS号108-24-7 乙酸酐 | CAS号65-46-3 胞嘧啶核苷 | CAS号5040-18-6 N-Acetyl-2'-O,3... | CAS号64-19-7 冰醋酸 | CAS号70740-24-8 1-(4-nitro-1H-b... | CAS号75-36-5 乙酰氯 | CAS号199593-08-3 N-乙酰基-5'-O-(4,4... | CAS号7481-89-2 2',3'-二脱氧胞苷 | CAS号951-77-9 2’-脱氧胞苷 | CAS号121058-88-6 美拉诺坦II | CAS号121058-82-0 5'-O-(4,4'-二甲氧基... | CAS号121058-85-3 5'-DMT-2'-TBDMS... | CAS号14631-20-0 N4-乙酰胞嘧啶 | CAS号120885-66-7 N4,O5'-diacetyl... | CAS号126430-20-4 N4-acetyl-5'-O-... | CAS号199593-09-4 2'-OMe-Ac-C 亚磷酰胺单体

胞苷置于phosphate Buffer,Aspergillus Niger Lipase Amano A,Sodium Acetate体系中,用 水 作为反应溶剂,化学反应 16.5H,反应生成 N-乙酰胞嘧啶核苷
参考文献:基于酶催化的脱乙酰基合成胞嘧啶的区域选择性保护形式是关键步骤.
标题:基于酶催化的脱乙酰基合成胞嘧啶的区域选择性保护形式是关键步骤.
摘要:N4-乙酰基胞苷(77%)和2',3'-O,N4-三乙酰基胞苷(95%)通过共同的前体,黑曲霉脂肪酶(amano A)和伯克霍尔德酒原洋葱酯酶的胞嘧啶过乙酰化形式获得(sc酯酶s),分别在非常温和的条件下使用.还详细说明了将三乙酰胞苷转化为相应的亚磷酰胺(82%)(糖核苷酸合成的中间体)的实验步骤.
DOI:10.1271/bbb.64.363

专利信息

专利号:US-4900828-A
优先权日:1988-05-12
标 题:Intermediate compounds and an improved procedure for the synthesis of 2',3'-dideoxycytidine
发明人：BELICA PETER S; HUANG TAI-NANG; MANCHAND PERCY S; PARTRIDGE JOHN J; TAM STEVE
权利人:HOFFMANN LA ROCHE
摘要:A method for the synthesis of 2',3'-dideoxycytidine comprising a novel procedure of bromoacetylating cytidine to yield novel intermediates which are subsequently reduced and hydrogenated by novel procedures to yield 2',3'-dideoxycytidine.

专利号:US-2023212204-A1
优先权日:2020-01-16
标题:Reagents and their use for modular enantiodivergent synthesis of c-p bonds
发明人：XU DONGMIN; RIVAS-BASCÓN NAZARET; KNOUSE KYLE W; PADIAL NATALIA; ZHENG BIN; VANTOUROUT JULIEN; SCHMIDT MICHAEL; EASTGATE MARTIN D; BARAN PHI
权利人:BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:The disclosure describes chiral P(V)-based reagents and their uses for the modular, scalable, and stereospecific synthesis of chiral phosphines, phosphine oxides and particular oligonucleotides.

专利号:US-8350022-B2
优先权日:2008-04-04
标题 :Method for the stereoselective synthesis of phosphorus compounds
发明人：MEIER CHRIS; THOMANN JENS O
权利人:UNIV HAMBURG; MEIER CHRIS; THOMANN JENS O
摘要:The present invention relates to a method for stereoselective synthesis of phosphorus compounds, whereby in the first reaction step a chiral auxiliary on the phosphorus atom of phosphoryl chloride, thiophosphoryl chloride or phosphorus trichloride is covalently bonded, the product from the first reaction step is reacted in the following step with an alcohol, thiol, or amine as the nucleophile in the presence of a base, and in the last step the chiral auxiliary is displaced from the product of the following step by a nucleophile.

专利号:WO-2024082545-A1
优先权日:2022-10-21
标 题:Method for enzymatic synthesis of nucleoside containing protecting group, and composition
发明人：HONG HAO; JAMES GAGE; XIAO YI; ZHANG NA; JIAO XUECHENG; LI MINGJI; LI RUI; DING SHIMAO
权利人:ASYMCHEM LIFE SCIENCE TIANJIN CO LTD
摘要:The present invention provides a method for enzymatic synthesis of a nucleoside containing a protecting group, and a composition. The method comprises: using pyrimidine nucleoside phosphorylase or uracil nucleoside phosphorylase and purine nucleoside phosphorylase to catalyze a substrate to synthesize a nucleoside containing a protecting group, wherein the substrate comprises a substrate nucleoside, a substrate base and a substrate phosphate, and the substrate base contains a protecting group; the pyrimidine nucleoside phosphorylase comprises a protein which has more than 80% homology with a protein PyNP shown in SEQ ID NO: 1; the uracil nucleoside phosphorylase comprises a protein which has more than 80% homology with a protein UP shown in SEQ ID NO: 2; and the purine nucleoside phosphorylase comprises a protein which has more than 80% homology with a protein PNP shown in SEQ ID NO: 3, 7 or 8. The present invention can solve the problem in the prior art that there is no biosynthesis method to produce a nucleoside containing a protecting group, and is suitable for the field of enzyme catalysis.

专利号:US-2014378538-A1
优先权日:2011-12-14
标 题:Methods of responding to a biothreat
发明人：BANCEL STEPHANE
权利人:MODERMA THERAPEUTICS INC
摘要:The present disclosure provides for devices, in particular mobile devices, which may be used in the synthesis of modified nucleic acid molecules, in particular modified mRNA molecules. The device for making the modified nucleosides, modified nucleotides and modified nucleic acids (e.g., mRNA) disclosed herein may be mobile devices comprising at least one sample block for insertion of one or more sample vessels, a device base with electronic control units for the sample block, a voltage supply, and one or more reagent(s) for the synthesis of at least one nucleic acid.

专利号:EP-0799313-A2
优先权日:1994-12-13
标 题 :Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses
发明人：BEIGELMAN LEONID; STINCHCOMB DANIEL T; JARVIS THALE; DRAPER KENNETH; PAVCO PAMELA; MCSWIGGEN JAMES; GUSTOFSON JOHN; USMAN NASSIM; WINCOTT FRANCINE; MATULIC-ADAMIC JASENKA; KARPEISKY ALEXANDER; THOMPSON JAMES D; MODAK ANIL; BURGIN ALEX
权利人:RIBOZYME PHARM INC
摘要:An enzymatic nucleic acid molecule which cleaves RNA associated with development or maintenance of an arthritic condition, induction of graft tolerance or reversal of an immune response. In particular, the ribozyme sequences are directed to an mRNA encoding B7-1, B7-2, B7-3, CD40 and/or stromelysin. Also provided are ribozymes where the uracil in positions 4 and/or 7 are substituted, as well as methods for the synthesis of 2'-alkylnucleotides, 2'-O-alkylthioalkyl, or 2'-alkylthioalkylnucleotides. The application further describes a method for diprotection of RNA with aqueous ethylamine, a method for synthesis of a basic ribonucleoside mimetics, and transcription units comprising an RNA polymerase II promoter, a U6 small nuclear promoter, or an adenovirus VA1 promoter system.