N-硝基氨基甲酸乙酯置于sodium Acetate,溶剂黄146体系中,化学反应生成 肼基甲酸乙酯 参考文献:Backer,Recueil Des Travaux Chimiques Des Pays-Bas,1912,Vol. 31,P. 20 标题:Backer,Recueil Des Travaux Chimiques Des Pays-Bas,1912,Vol. 31,P. 20
专利号:WO-9847910-A1 优先权日:1997-04-21 标题:Method for solution phase synthesis of oligonucleotides 发明人:PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING; HILL KEN; SMITH RANDALL S 权利人:NEXSTAR PHARMACEUTICALS INC; PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING; HILL KEN; SMITH RANDALL S 摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.
专利号:US-9988492-B2 优先权日:2013-09-30 标题:Methods for post-fabrication functionalization of poly(ester ureas) 发明人:BECKER MATTHEW; LIN FEI 权利人:BECKER MATTHEW; LIN FEI; UNIV AKRON 摘要:Amino acid-based poly(ester urea)s (PEU) are emerging as a class of polymers that have shown promise in regenerative medicine applications. Embodiments of the invention relate to the synthesis of PEUs carrying pendent “clickableâ€? groups on modified tyrosine amino acids. The pendent species include alkyne, azide, alkene, tyrosine-phenol, and ketone groups. PEUs with M w exceeding 100k Da were obtained via interfacial polycondensation methods and the concentration of pendent groups was varied by copolymerization. The incorporation of derivatizable functionalities is demonstrated using 1 H NMR and UV-Vis spectroscopy methods. Electrospinning was used to fabricate PEU nanofibers with a diameters ranging from 350 nm to 500 nm. The nanofiber matricies possess mechanical strengths suitable for tissue engineering (Young's modulus: 300±45 MPa; tensile stress: 8.5±1.2 MPa). A series of bioactive peptides and fluorescent molecules were conjugated to the surface of the nanofibers following electrospinning using bio-orthogonal reactions in aquous media.
专利号:US-6600001-B1 优先权日:2002-01-11 标 题:Alkylamino oxamides as low odor, non-fugitive catalysts for the production of polyurethanes 发明人:GERKIN RICHARD M; ROBINSON KARENA KAYE; DERERIAN EDMOND J 权利人:CROMPTON CORP 摘要:A process for the synthesis of polyurethanes is disclosed wherein the process comprises reacting polyurethane-forming reactants in the presence of an effective amount of a catalyst comprising at least one alkylamino oxainide of the structure:wherein:R1 and R2 are independently selected alkyl groups or can be taken together to form a five or six-membered heterocyclic ring;R3 and R4 are independently selected from the group consisting of hydrogen and alkyl;n is 2 or 3;x is 0 or 1;Y is selected from the group consisting of O and NR9, wherein:R9 is selected from the group consisting of hydrogen and alkyl; andX is selected from the group consisting of OR10 and G, wherein:R10 is selected from the group consisting of hydrogen and alkyl; andG is
专利号:US-9265773-B2 优先权日:2011-09-08 标题 :Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases 发明人:MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; HE SHUWEN; DAI XING; LIU HONG; LAI ZHONG; LONDON CLARE; XIAO DONG; ZORN NICOLAS; NARGUND RAVI 权利人:MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; HE SHUWEN; DAI XING; LIU HONG; LAI ZHONG; LONDON CLARE; XIAO DONG; ZORN NICOLAS; NARGUND RAVI; MERCK SHARP & DOHME; MSD ITALIA SRL 摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
专利号:US-8367812-B2 优先权日:2005-05-26 标 题:Preparation of organosilicon compounds 发明人:STERIN SEBASTIEN 权利人:RHODIA CHIMIE SA; STERIN SEBASTIEN 摘要:The synthesis of purified functionalized organosilicon compounds containing at least one active azo group having formula (I): [(G 0 ) 3 SiO 1/2 ] m [(G 0 ) 2 SiO 2/2 ] n [G 0 SiO 3/2 ] o [SiO 4/2 ] p [(G 2 ) a (G 1 ) a′ (Z—CO—HNâ•?NH—CO-A)SiO (3-a-a′)/2 ] entails providing at least one hydrazino (—HN—NH—) precursor (II) of the compound (I) and oxidizing the precursor (II) into an azo group specific to the compound (I) with the aid of an oxidizing system comprising at least one oxidant (Ox) and at least one base (B), wherein 1) Ox is selected from among the oxidants that can oxidize a hydrazine function into an azo function, with or without the exclusion of N-bromosuccinimide (NBS), 2) and/or Ox (optionally B) is/are employed in stoichiometric quantities in relation to the precursor (II); 3) and/or the organosilicon compounds (I) thus prepared are subjected to a purification post-treatment to eliminate any unwanted residues of the base B used, with the proviso that, when NBS is not excluded, characteristic (1) is combined with charcteristic (2) and/or characteristic (3).
专利号:EP-1070733-A1 优先权日:1999-07-21 标题:Method of synthesis of polyaminofunctional hydroxyurethane oligomers and hybride polymers formed therefrom 发明人:FIGOVSKY OLEG; SHAPOVALOV LEONID; BLANK NELLY; BUSLOV FLORIDA 权利人:POLYMATE LTD; CHEMONOL LTD 摘要:Chemically resistant materials with high mechanical properties are provided by usingnadducts of primary diamines (with oligocyclocarbonate and epoxy compounds) andnepoxy oligomers with ended epoxy groups (or mixture of epoxy oligomers andnoligomercaptanes).
摘要:Gnanaprakasam, B.; Chaudhari, M. B., Science of Synthesis Knowledge Updates, (2019) 2, 414. 摘要:Archives of Environmental Contamination and Toxicology., 12(355), 1983 [] 摘要:Schafer, E. W., Jr., W. A. Bowles Jr., and J. Hurlbut. 1983. The acute oral toxicity and repellency and hazard potential of 998 chemicals to one or more species of wild and domestic birds. Archives of Environmental Contamination and Toxicology 12:355-382. 摘要:Schafer, E.W., Jr., et al. 1982. Effects of 77 chemicals on reproduction in male and female coturnix quail. Ecotox. Environ. Safety 6:149-156 参考文献:10.1107/s1600536810020623 摘要:Li YF, Sheng WH, Jian FF. Ethyl 3-(4-methyl-benzyl-idene)carbazate. Acta Crystallogr Sect E Struct Rep Online. 2010 Jun 05;66(Pt 7):o1565.