CAS: 479-13-0; Coumestrol

该化合物是属于Coumpstan化合物类别的自然形成的植物性素,主要见于诸如Alfalfa和culver等豆类,以及大豆.结构上,它具有一种带有氢氧基的库姆斯坦核心,有助于其雌性致癌活动. Coumestro表现出明显的抗氧化特性,并研究其在调控雌激素受体途径方面的潜在作用.它与ER-β高度结合,使它成为内分泌研究的话题.此外,它显示了生理条件下的稳定性,促进了体外和活性研究.Coumersterol经常用于生物化学研究,以调查植物性相互作用及其对健康和疾病的影响.

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3-(2,4-dimethoxy-phenyl)-4,7-dihydroxy-coumarin 3-(2,4-dimethoxyphenyl)-4-hydroxy-7-methoxy-1-benzopyran-2-one 2,3-bis-(2,4-dimethoxy-phenyl)-3-oxo-propionitrile Coumestrol dimethyl ether2-(2,4-dimethoxy-phenyl)-6-methoxy-benzofuran-3-carboxylic acid methyl ester Coumestrol dimethyl ether 3,9-Bis-(tert-butyl-dimethyl-silanyloxy)-6-phenoxy-6H-benzo[4,5]furo[3,2-c]chromene

合成工艺路线路线简述

    2-(2,4-二甲氧基苯基)乙腈置于盐酸,乙醚,Aniline Hydrochloride,Potassium Carbonate,丙酮体系中,化学反应生成 考迈斯托醇
    参考文献:Synthesis Of Coumestrol,3,9-Dihydroxy-6H-Benzofuro [3,2-C] [1] Benzopyran-6-One1
    标题:Synthesis Of Coumestrol,3,9-Dihydroxy-6H-Benzofuro [3,2-C] [1] Benzopyran-6-One1
    摘要:
    DOI:10.1021/ja01549A067

    海关参考信息

    专利信息


    专利号:US-7759473-B2
    优先权日:2005-02-14
    标题:Nucleotide oligomer, nucleotide polymer, method for determining structure of functional substance and method for manufacturing functional substance
    发明人:FUJIHARA TSUYOSHI; FUJITA SHOZO
    权利人:FUJITSU LTD
    摘要:A modified nucleotide n-mer (where n is an integer of 2 or more) is used which comprises a nucleoside unit with a substituent group introduced into the base, wherein the substituent group is bound to the base via a triple bond. Novel nucleotide oligomers, nucleotide polymers, and nucleosides which can be used as raw materials or intermediates in the synthesis of this nucleotide oligomer and nucleotide polymer, as well as novel techniques for structural determination and manufacture of a functional substance having high affinity for a target, are provided.

    专利号:US-8541191-B2
    优先权日:2008-08-29
    标 题 :Hydrolases, nucleic acids encoding them and methods for biocatalytic synthesis of structured lipids
    发明人:DAYTON CHRISTOPHER L G; HITCHMAN TIM; KLINE KATIE; LYON JONATHAN; WALL MARK A; BARTON NELSON R
    权利人:DAYTON CHRISTOPHER L G; HITCHMAN TIM; KLINE KATIE; LYON JONATHAN; WALL MARK A; BARTON NELSON R; BUNGE OILS INC
    摘要:Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase activity, e.g., lipases, saturases, palmitases and/or stearatases and methods for preparing low saturate or low trans fat oils, such as low saturate or low trans fat animal or vegetable oils, e.g., soy or canola oils.

    专利号:US-6849701-B2
    优先权日:2001-03-02
    标 题:Droplet polymerization method for synthesis of molecularly imprinted polymers
    发明人:NORTON TUCKER
    权利人:DU PONT
    摘要:A droplet polymerization process is provided to create efficacious molecularly imprinted polymers (MIPs). Such imprinted polymers have increased surface area for adsorptive or catalytic reactions. This method provides for monomer-template interactions in the absence of a suspending medium, thereby permitting formation of MIPs with increased template selectivity and substantial processing advantages. The process is particularly useful for separating isoflavones from soy whey.

    专利号:US-2014357576-A1
    优先权日:2013-05-31
    标题:Methods for enhancement of muscle protein synthesis
    发明人:BREUILLE DENIS; STELLINGWERFF TRENT; MOORE DANIEL RYAN; OFFORD CAVIN ELIZABETH ANN; PHILLIPS STUART MARTIN
    权利人:NESTEC SA
    摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis by enhancing myofibrillar muscle protein synthesis. The method includes administering to the individual a mixed macronutrient composition having (i) an amount of whey protein that is not capable of enhancing myofibrillar protein synthesis when ingested by itself and (ii) free leucine. The composition comprises at least about 5.0 g total leucine per dose.

    专利号:WO-2015040533-A1
    优先权日:2013-09-19
    标题:Methods for enhancing muscle protein synthesis during energy deficit
    发明人:BAILEY DAVID MARK; ZALTAS ERIC SCOTT; STELLINGWERFF TRENT; MOORE DANIEL RYAN; HAWLEY JOHN ALAN; BURKE LOUISE MARY
    权利人:PREMIER NUTRITION CORP
    摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis during periods of negative energy balance, or energy deficit. The methods include administering to an individual suffering from energy deficit a composition comprising protein in an amount from about 15 g to about 30 g during a time period selected from the group consisting of during exercise, post-exercise, and combinations thereof. The methods also include administering to an individual suffering from energy deficit a composition comprising protein during a time period selected from the group consisting of during exercise, post-exercise, and combinations thereof, wherein the protein is administered in a dose that is higher than doses typically recommended for individuals experiencing energy balance.

    专利号:US-2014294788-A1
    优先权日:2013-03-26
    标 题 :Methods for enhancing muscle protein synthesis following concurrent training
    发明人:BAILEY DAVID MARK; ZALTAS ERIC SCOTT; MOORE DANIEL RYAN; STELLINGWERFF TRENT
    权利人:NESTEC SA
    摘要:The present disclosure provides methods for enhancing muscle protein synthesis following physical exertion. In a general embodiment, a method for enhancing muscle protein synthesis following physical exertion is provided and includes administering to an individual a composition comprising from about 15 to about 35 g protein immediately following concurrent training. Programs for enhancing muscle adaptation resulting from concurrent training are also provided. The programs include providing a composition comprising from about 15 to about 35 g protein; and providing guidelines for consumption including a recommendation of the amount of the composition to consume immediately following concurrent training.
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    主要参考文献


    1: Park G, Baek S, Kim JE, Lim TG, Lee CC, Yang H, Kang YG, Park JS, Augustin M, Mrosek M, Lee CY, Dong Z, Huber R, Lee KW. Flt3 is a target of coumestrol in protecting against UVB-induced skin photoaging. Biochem Pharmacol. 2015 Dec 1;98(3):473-83. doi: 10.1016/j.bcp.2015.08.104. Epub 2015 Sep 2. doi: 10.1016/j.steroids.2013.11.019. Epub 2013 Dec 5. doi: 10.1021/jf404882w. Epub 2014 Apr 30. doi: 10.1016/j.bmcl.2014.03.084. Epub 2014 Apr 3. doi: 10.1186/2050-6511-14-36.
    6: Castro CC, Pagnussat AS, Moura N, da Cunha MJ, Machado FR, Wyse AT, Netto CA. Coumestrol treatment prevents Na+, K+ -ATPase inhibition and affords histological neuroprotection to male rats receiving cerebral global ischemia. Neurol Res. 2014 Mar;36(3):198-206. doi: 10.1179/1743132813Y.0000000286. doi: 10.1530/JOE-15-0418. Epub 2015 Dec 23. doi: 10.1016/j.theriogenology.2013.06.002. Epub 2013 Jul 9. doi: 10.1002/tox.20735. Epub 2011 Jun 7. doi: 10.1111/asj.12007. Epub 2012 Dec 3. doi: 10.1016/j.jchromb.2016.03.012. Epub 2016 Mar 15. doi: 10.1002/jcp.25381. Epub 2016 Mar 30. doi: 10.1016/j.foodchem.2013.03.053. Epub 2013 Mar 23. doi: 10.1016/j.brainres.2012.07.025. Epub 2012 Jul 21. doi: 10.1002/jsfa.5835. Epub 2012 Aug 28. doi: 10.1128/AEM.07336-11. Epub 2012 Feb 3.
    18: Liu H, Wang L, Ma H, Guo R, Kang R, Han J, Dong Z. Coumestrol inhibits carotid sinus baroreceptor activity by cAMP/PKA dependent nitric oxide release in anesthetized male rats. Biochem Pharmacol. 2015 Jan 1;93(1):42-8. doi: 10.1016/j.bcp.2014.11.001. Epub 2014 Nov 13. doi: 10.1016/j.jnutbio.2016.03.003. Epub 2016 Mar 29. doi: 10.1016/j.jep.2015.04.028. Epub 2015 Apr 28.

    合成参考文献


    参考文献:10.1007/s00203-011-0729-2
    摘要:Margaret-Oliver I, Lei W, Parada M, Rodríguez-Carvajal MA, Crespo-Rivas JC, Hidalgo Á, Gil-Serrano A, Moreno J, Rodríguez-Navarro DN, Buendía-Clavería A, Ollero J, Ruiz-Sainz JE, Vinardell JM. Sinorhizobium fredii HH103 does not strictly require KPS and/or EPS to nodulate Glycyrrhiza uralensis, an indeterminate nodule-forming legume. Arch Microbiol. 2012 Feb;194(2):87–102. doi: 10.1007/s00203-011-0729-2.
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