CAS: 75985-45-4; Pyrimidin-2-Ylmethanamine

上下游产品

CAS号14080-23-0 2-氰基嘧啶 | CAS号330784-47-9 阿伐那非 | CAS号1260843-26-2 (嘧啶-2-基甲基)氨基甲酸叔丁酯

2-氰基嘧啶置于pd-C,氨 氢气体系中,用 乙醇 作为反应溶剂,化学反应生成 2-甲胺基嘧啶
参考文献:7-Azaisoindolinyl-Quinolone-Carboxylic Acid Derivatives
标题:7-Azaisoindolinyl-Quinolone-Carboxylic Acid Derivatives
摘要:这项发明涉及新的喹诺酮羧酸衍生物,其在7位被一个可选择部分氢化的氮杂异吲哚环取代,以及它们的制备过程,以及含有它们的抗菌剂和饲料添加剂.

专利信息

专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

专利号:CN-117430591-A
优先权日:2023-10-31
标 题:Synthesis method of avanafil