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二碳酸二叔丁酯置于potassium Carbonate,三乙胺体系中,用 四氢呋喃,N,N-二甲基甲酰胺 用作溶剂,化学反应生成二(2-甲基-2-丙基)(亚氨基二-2,1-乙二基)二氨基甲酸酯
参考文献:利用拟肽合成激活ryanodine受体钙释放通道的化合物
标题:利用拟肽合成激活ryanodine受体钙释放通道的化合物
摘要:Ryanodine受体(ryr)ca 2+释放通道对于骨骼肌和心肌的收缩至关重要,并且是影响骨骼或心脏肌肉系统疾病的收缩修饰的主要靶点.我们设计和合成了许多化合物,这些化合物的结构基于修饰ryrs活性的天然肽(a肽).总共制备了8种不同类别的34种化合物.筛选化合物增强从孤立的心脏肌浆网(sr)囊泡释放ca 2+的能力,其中25种显示增强的ca 2+释放.与母体肽的竞争研究表明,合成化合物在竞争位点起作用.使用ca 2+从骨骼sr小泡中释放以及在完整的骨骼肌纤维中收缩,进一步探索了最有效的化合物bit 180的活性.这些化合物没有改变完整纤维的张力,表明(如预期的那样)它们不是膜可渗透的,但重要的是,它们对完整细胞没有毒性.原则上证明,如果使用与结构相关的膜可渗透蝎毒(抗毒素a)获得膜可渗透性,则该化合物对膜可渗透性将是有效的,发现这种蝎子毒素可增强收缩力.
Doi:10.1002/cmdc.201800366

专利信息

专利号:US-7501526-B2
优先权日:2005-01-20
标题 :Synthesis of polyamine compounds
发明人：WU CHIEN-HUANG; ZHU JIA-LIANG; TSENG CHEN-TSO; YEN CHI-FENG; SHIA KAK-SHAN; XIANG YIBIN; HAKIMELAHI GHOLAM HOSSEIN; CHOU MING-CHEN
权利人:TAIGEN BIOTECHNOLOGY CO LTD
摘要:This invention relates to methods of preparing the compounds of formula (V): n nEach variable in this formula is defined in the specification.

专利号:US-11471537-B2
优先权日:2017-04-05
标题 :Oligomer extended insulin-Fc conjugates
发明人：MOELLER TAGMOSE TINA; MADSEN PETER; KJELDSEN THOMAS BOERGLUM; PRIDAL LONE; DE MARIA LEONARDO; LIN ZHAOSHENG; Wan zhe; ZHANG YUANYUAN; LYKKE LENNART; MUENZEL MARTIN WERNER BORCHSENIUS; KODRA JANOS TIBOR
权利人:NOVO NORDISK AS
摘要:This invention is in the field of protein conjugates. More specifically the invention relates to oligomer extended insulins with covalently attached Fc monomer polypeptides, for use in the treatment of a metabolic disorder or condition, and to methods of producing such oligomer extended insulin-Fc conjugates. The invention also relates to novel Fc fragments, to intermediate products, and to the use of such intermediate products in processes for the synthesis of the oligomer extended insulin-Fc conjugates of the invention. Finally the invention provides pharmaceutical compositions comprising the oligomer extended insulin-Fc conjugates of the invention, and relates to the use of such compositions for the treatment or prevention of medical conditions relating to metabolic disorders or conditions.

专利号:US-2006160860-A1
优先权日:2005-01-20
标题:Synthesis of polyamine compounds

专利号:WO-0039055-A1
优先权日:1998-12-23
标 题:Rapid purification by polyaromatic quench reagents
发明人：DA SILVA MARIANNE; DOWNING DENNIS MICHAEL; WARMUS JOSEPH SCOTT; ZHANG LU-YAN
权利人:WARNER LAMBERT CO; DA SILVA MARIANNE; DOWNING DENNIS MICHAEL; WARMUS JOSEPH SCOTT; ZHANG LU YAN
摘要:Novel polyaromatic hydrocarbon quenching reagents of Formula (I), wherein: P is a polyaromatic hydrocarbon of low chemical reactivity which is soluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; and L is one or more chemically robust linkers or dendritic linkers that join P and Q; are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis.

专利号:US-2009240028-A1
优先权日:2003-08-08
标 题:Synthesis and Application of New Structural Well Defined Branched Polymers as Conjugating Agents for Peptides

专利号:US-2006182714-A1
优先权日:2003-08-08
标题:Synthesis and application of new structural well defined branched polymers as conjugating agents for peptides