CAS: 26218-78-0; Methyl 6-Bromonicotinate

相似化合物

122306-01-8 149806-06-4 6311-35-9

上下游产品

CAS号67-56-1 甲醇 | CAS号6311-35-9 6-溴烟酸 | CAS号73781-91-6 6-氯烟酸甲酯 | CAS号18107-18-1 (三甲硅烷)重氮甲烷 | CAS号5006-66-6 6-羟基烟酸 | CAS号7789-69-7 五溴化磷 | CAS号584-08-7 碳酸钾 | CAS号74-95-3 二溴甲烷 | CAS号1603-41-4 2-氨基-5-甲基吡啶 | CAS号3510-66-5 2-溴-5-甲基吡啶 | CAS号4634-13-3 6-苯基烟酸甲酯 | CAS号209971-44-8 6-{[[(4-甲基苯基)磺酰... | CAS号132144-03-7 6-哌嗪-1-烟酸甲酯 | CAS号122306-01-8 6-溴吡啶-3-甲醇 | CAS号179408-54-9 6-THIEN-2-YLNIC...

6-溴烟酸置于硫酸,碳酸氢钠体系中,用 甲醇 用作溶剂,以66%的收率获得6-溴烟酸甲酯
参考文献:在heck反应中具有空前活性的新型双层负载型离子液体催化剂(silca)的制备和表征
标题:在heck反应中具有空前活性的新型双层负载型离子液体催化剂(silca)的制备和表征
摘要:设计了一种新型的负载钯的双层负载型离子液体催化剂(silca),并将其成功应用于碘代苯与丙烯酸甲酯的heck反应.由第一离子液体层(共价锚定的溴化咪唑鎓)组成的二氧化硅改性催化剂,其上连接了第二层(由吡啶羧酸与四甲基胍鎓阳离子平衡而成),从而形成了高活性的催化剂.22,000 H-1的高周转频率在低钯负载量为0.009 Mol%的反应中获得了5%的碳原子数.较低的tof,表明当使用更高的量时,检测到钯二聚化.Tmg阳离子具有重新捕获和稳定pd纳米颗粒的目的,因此遵循释放和捕获机制.为了充分了解催化剂的结构和性能,通过氮物理吸附,热重分析,红外光谱,扫描电子和透射电子显微镜,固态NMR,X射线光电子能谱和感应法对催化剂进行了表征.耦合等离子体光谱.该催化剂在五个循环中保持了非常好的活性.
Doi:10.1016/j.Jcat.2019.01.029

专利信息

专利号:US-8487094-B2
优先权日:2008-07-25
标题 :Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1
发明人：FANDRICK KEITH R; GAO JOE JU; LI WENJIE; LU ZHI-HUI; ZHANG YONGDA
权利人:FANDRICK KEITH R; GAO JOE JU; LI WENJIE; LU ZHI-HUI; ZHANG YONGDA; BOEHRINGER INGELHEIM INT
摘要:Disclosed are syntheses of 11β-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticoid effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).

专利号:WO-2023203374-A1
优先权日:2022-04-20
标 题 :[1,2]selenazolo[2,3-a]pyridin-8-ium inhibitors of pyruvate kinase isoform m2
发明人：ARSENJANS PAVELS; DIMITRIJEVS PAVELS; MAKRECKA-KUKA MARINA
权利人:LATVIAN INST ORGANIC SYNTHESIS
摘要:The present invention relates to a novel isoselenazolopyridinium salts as anticancer agents by inhibiting pyruvate kinase isoform M2 (PKM2) activity, as well as methods of their manufacturing and use in different pharmaceutical compositions for the treatment of various diseases and disorders by administration of such substances.

专利号:US-9919064-B2
优先权日:2012-08-10
标 题 :Compositions, methods, and systems for the synthesis and use of imaging agents
发明人：CESATI RICHARD R; RADEKE HEIKE S; PANDEY SURESH K; PUROHIT AJAY; ROBINSON SIMON P
权利人:LANTHEUS MEDICAL IMAGING INC
摘要:The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

专利号:US-2010004245-A1
优先权日:2006-10-20
标 题:Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：OBALLA RENATA M; DESCHENES DENIS; GAGNON MARC; LEBLANC YVES; POWELL DAVID; RAMTOHUL YEEMAN K
权利人:MERCK FROSST CANADA LTD
摘要:Azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:WO-2009017671-A1
优先权日:2007-07-26
标题 :Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1

专利号:US-2010256363-A1
优先权日:2007-07-26
标题 :SYNTHESIS OF INHIBITORS OF 11ß-HYDROXYSTEROID DEHYDROGENASE TYPE 1