CAS: 278788-66-2; (R)-Tert-Butyl 3-(Hydroxymethyl)Piperazine-1-Carboxylate

相似化合物

301673-16-5 314741-40-7 205434-75-9

上下游产品

N-B°C-piperazine-2-amidoanhydride (R)-tert-butyl-3-(O-tert-butyldiphenylsilane)methyl-piperazine-1-carboxylate (R)-tert-butyl 3-(hydroxymethyl)-4-methylpiperazine-1-carboxylate 1,1-dimethylethyl (3R)-4-[3-fluoro-5-(trifluoromethyl)-2-pyridinyl]-3-(hydroxymethyl)-1-piperazinecarboxylate (R)-4-(2-chloroacetyl)-3-(hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester

N-Boc-Piperazine-2-Amidoanhydride置于sodium Tetrahydroborate体系中,用 乙醇 用作溶剂,化学反应 48.0H,以50%的收率获得(R)-1-Boc-3-羟甲基哌嗪
参考文献:Farnesyl Protein Transferase Inhibitors
标题:Farnesyl Protein Transferase Inhibitors

专利信息

专利号:US-9695191-B2
优先权日:2009-08-05
标题 :Conformationally constrained, fully synthetic macrocyclic compounds
发明人：OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; LACH FRANCK; LUTHER ANATOL; MARX KARSTEN; MÖHLE KERSTIN
权利人:OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; LACH FRANCK; LUTHER ANATOL; MARX KARSTEN; MÖHLE KERSTIN; POLYPHOR AG
摘要:Conformationally restricted, spatially defined 12-30 membered macrocyclic ring systems of type (I) are constituted by three distinct building blocks: an aromatic template a, a conformation modulator b and a spacer moiety c as detailed in the description and the claims. Macrocycles of type (I) are readily manufactured by parallel synthesis or combinatorial chemistry. They are designed to interact with specific biological targets. In particular, they show agonistic or antagonistic activity on the motilin receptor (MR receptor), on the serotonin receptor of subtype 5-HT 2B (5-HT 2B receptor), and on the prostaglandin F2•receptor (FP receptor). They are thus potentially useful for the treatment of hypomotility disorders of the gastrointestinal tract such as diabetic gastroparesis and constipation type irritable bowl syndrome; of CNS related diseases like migraine, schizophrenia, psychosis or depression; of ocular hypertension such as associated with glaucoma and preterm labour.