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3-羟基苯甲酸乙酯置于硫酰氟,四甲基氟化铵,Potassium Carbonate体系中,用 乙酸乙酯,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 24.0H,反应生成 3-氟苯甲酸乙酯
参考文献:通过芳基氟磺酸酯中间体对苯酚进行亲核脱氧氟化
标题:通过芳基氟磺酸酯中间体对苯酚进行亲核脱氧氟化
摘要:本报告描述了一种通过芳基氟磺酸 (Arofs) 中间体使用硫酰氟 (So2F2) 和四甲基氟化铵 (Nme4F) 对苯酚进行脱氧氟化的方法.我们首先证明 Arofs 与 Nme4F 的反应在温和条件下(通常在室温下)进行,以提供广泛的电子多样化和富含官能团的芳基氟化物产品.然后将该转化转化为使用 So2F2 和 Nme4F 的组合将苯酚一锅法转化为芳基氟化物.从头算计算表明,碳-氟键的形成是通过协调的过渡态而不是离散的迈森海默中间体进行的.
DOI:10.1021/jacs.6B12911

专利信息

专利号:US-7993494-B2
优先权日:2008-01-23
标题:Method for manufacturing triarylpyrazine derivative
发明人：INOUE HIDEKO; NOMURA HIROKO
权利人:SEMICONDUCTOR ENERGY LAB
摘要:A novel synthesis method of a triarylpyrazine derivative, in particular, a manufacturing method by which a triarylpyrazine derivative, in specific, a 2,3,5-triarylpyrazine derivative in which an aryl group at a 5-position includes a substituent having an electron-withdrawing property can be synthesized with high yield as compared to a conventional method is provided. By using a synthesis method in which a mixture including a 1-aryl-2-(methylsulfinyl)ethanone derivative, meso-1,2-diarylethylenediamine, and a dehydrogenation agent is irradiated with a microwave to be reacted, the above object is achieved.