CAS: 52315-75-0; (S)-2-Amino-6-Dodecanamidohexanoic Acid

该化合物是一种合成的氨基酸衍生物,由酸与L-lysine结合而成,由于它独特的分子结构,它具有极好的乳化和地表活性特性,它结合了水益(lysine)和水分(lauroyl-L-lysine)的分子结构,它广泛用于化妆品配方,作为调制剂,改进质质质和可传播性,同时提高皮肤的兼容性;它的生物兼容性和温度使它适合敏感应用;此外,N-L-L-lysine作为乳胶中的一种稳定剂,能够改变制剂的病理特性;它的无刺激性性和生物降解性,进一步有助于它在可持续产品开发中的吸引力.

结构式图片

上下游产品

lauric acid L-lysine methyl n-dodecanoateα,Nε-bis(1-oxododecyl)-L-lysineNα,Nε-bis(1-oxododecyl)-L-lysine α-(cyclohexylcarbonyl)-Nε-(1-oxododecyl)-L-lysineNα-(cyclohexylcarbonyl)-Nε-(1-oxododecyl)-L-lysine

合成工艺路线路线简述

  • 合成目标产物 N'-Laruoyl-L-Lysine 主要起始原料 Lauric Acid And L-Lysine
  • (文献来源)合成步骤主要原料 Lauric Acid 和 L-Lysine
月桂酰氯,L-赖氨酸盐酸盐置于水,Sodium Dodecyl-Sulfate,Sodium Hydroxide体系中,用 乙醇,正己烷,水 作为反应溶剂,以76 %的收率获得产物n-(十二酰基)赖氨酸
参考文献:Cn117164470
标题:Cn117164470

海关参考信息

专利信息


专利号:WO-2006097348-A1
优先权日:2005-03-15
标 题:Use of agents such as nonpolymeric nitric oxide donors for making the lips full again and/or colouring the lips
发明人:CALS-GRIERSON MARIE-MADELEINE
权利人:OREAL; CALS-GRIERSON MARIE-MADELEINE
摘要:The invention relates in particular to the cosmetic use (i) of at least one agent for promoting the production of NO in and/or on the lips, chosen from nitric oxide NO donors or precursors; nonpolymeric NO releasers; and NO synthase synthesis and/or activity stimulators; or (ii) of other agents for promoting microcirculation in the skin, chosen from potassium channel openers; calcium channel blockers; phosphodiesterase inhibitors; flavonoids; vasodilator peptides that are not NO donors; temperature modulators; agents for promoting the stimulation and/or maintenance of angiogenesis; agents for promoting the stimulation of endothelial cell proliferation; agents for promoting endothelial cell migration; and mixtures thereof, in a makeup and/or care composition for the lips, as an agent for naturally making the lips full again and/or naturally coloring the lips. It also relates to specific care and/or makeup compositions for the lips containing said agent, and also to a cosmetic process aimed at making the lips naturally full and/or colored, using said compositions .

专利号:US-2020123103-A1
优先权日:2017-05-12
标 题 :Method for the synthesis of an n-acyl compound without the use of organic solvent or acid chloride

专利号:US-12226379-B2
优先权日:2022-02-08
标 题 :Highly sustainable compositions for modulation of gene expression in human skin, and methods of production thereof
发明人:DUGAR DEEPAK
权利人:VISOLIS TECH INC; VISOLIS INC
摘要:Formulations containing biologically-produced, high-purity R-mevalonolactone are provided for modulating the expression of genes and metabolism related to epidermal turnover, hyaluronic acid synthesis, barrier function, anti-aging elasticity, extracellular matrix degradation, inflammation, stress, and pigmentation in human skin. The biologically-produced, high-purity R-mevalonolactone may be used as an ingredient in pharmaceutical, food, or cosmetic products and may be applied topically or ingested for modulation of gene expression and metabolism.

专利号:WO-2004096171-A1
优先权日:2003-04-29
标题 :Skin whitening cosmetic composition comprising the extract of machilus thunbergii and the compounds isolated therefrom
发明人:SON JONG-KEUN; LEE SEUNG-HO; CHANG HYEUN-WOOK
权利人:YEUNGNAM EDUCATIONAL FOUND; SON JONG-KEUN; LEE SEUNG-HO; CHANG HYEUN-WOOK
摘要:The present invention is related to a cosmetic composition comprising the extract of Machilus thunbergii and lignan compounds isolated therefrom having potent inhibitory effect on melanin synthesis. Inventive composition shows the excellent inhibitory activity on cultured B-16 melanoma cell therefore, it can be useful in skin whitening cosmetic composition as an cream, skin, lotion, pack and the like.

专利号:US-8361516-B2
优先权日:2006-08-03
标 题:Composition comprising sarsasapogenin
发明人:LINTNER KARL; MAS CHAMBERLIN CLAIRE
权利人:SEDERMA SA; LINTNER KARL; MAS CHAMBERLIN CLAIRE
摘要:The présent invention relates to a composition comprising sarsasapogenin or a plant extract containing it in order to improve the gêneral state of the skin and in particular to improve and/or embellish any part of the body showing a déficit in lipids. More particularly, the invention is directed to a cosmetic method to improve the figure, comprising the step of topically applying to the skin a cosmetic or dermopharmaceutical composition comprising sarsasapogenin to favour the expansion and/or the formation of the subcutaneous adipose tissue, and/or to favour the lipid synthesis in the epidermis.

专利号:US-6268454-B1
优先权日:1999-10-06
标 题:Amino acid silicon polymer, method for preparing the same, cosmetic particles surface-treated with the same, and cosmetic composition containing the particles
发明人:SONG DONG HYUK; CHOI YEONG JIN; KIM KIL JOONG; LEE YOUNG CHUL
权利人:PACIFIC CORP
摘要:The invention relates to a novel amino acid silicon polymer with good adhesion to the keratin layer of the skin, a method of preparing the amino acid silicon polymer, a cosmetic particles surface-treated with the amino acid silicon polymer, and a color cosmetic composition including the cosmetic particles. According to the present invention, the particles surface-treated up to 3% to the maximum with the amino acid silicon polymer prepared by reacting an amino acid and a functional silicon polymer in the manner of organic synthesis have water resistance and usability peculiar to silicon-treated pigments and take positive surface charges, thereby offering good adhesion to the skin and durability. Due to these characteristics, the cosmetic containing the surface-treated particles of the present invention is superior in the cosmetic effect to that containing the conventional surface-treated particles.
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主要参考文献


1: Koreishi M, Kawasaki R, Imanaka H, Imamura K, Takakura Y, Nakanishi K. Efficient Nepsilon-lauroyl-L-lysine production by recombinant epsilon-lysine acylase from Streptomyces mobaraensis. J Biotechnol. 2009 May 20;141(3-4):160-5. doi: 10.1016/j.jbiotec.2009.03.008. Epub 2009 Mar 27. doi: 10.1016/j.jcis.2009.09.010. Epub 2009 Sep 13. doi: 10.1016/j.ejmech.2008.11.003. Epub 2008 Nov 14. doi: 10.3109/03639045.2012.665928. Epub 2012 Mar 15.
13: Sugimoto Y, Toyoshima S. Influence of chemical modification of N alpha-cocoyl-L-arginine ethyl ester on its hepatitis B surface antigen-inactivating effect. Antimicrob Agents Chemother. 1980 Oct;18(4):525-8.
14: Burnett CL, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics. Int J Toxicol. 2017 May/Jun;36(1_suppl):17S-56S. doi: 10.1177/1091581816686048.

合成参考文献


摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118
摘要:International Journal of Toxicology 36(Suppl. 1):17-56, 2017
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