CAS: 530-59-6; 3,5-Dimethoxy-4-Hydroxycinnamic Acid

该化合物是一种自然形成的氢辛基酸衍生物,广泛用作矩阵辅助激光解吸/离子(MALDI)质谱测量的矩阵.其主要优点包括强效紫外线吸收,高效电离特性和与广泛的解析物,特别是peptides,蛋白质和甘油的兼容性.该化合物的结构特征 --一种交融的双联和苯基氢氧基化合物组 --强化其在脱氧和高分子份电离子生物分子分子分子中的性能. 硅酸还展示了抗氧化剂活动,使其在生物化学研究中具有价值. 在激光辐照下,其稳定性和可复制性进一步巩固了其作为蛋白质学和代谢研究中首选的矩阵的作用.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

sodium acetate acetic anhydride syringic aldehyde sinalbin 1‐O‐sinapoyl‐beta‐D‐glucose N-succinimidyl sinapate 2,6-dimethoxy-p-quinone 2-hydroxyresorcinol

合成工艺路线路线简述

    Methyl Sinapate置于3-吗啉丙磺酸,溶剂黄146体系中,化学反应 0.17H,反应生成 芥子酸
    参考文献:Dependency Of The Hydrogen Bonding Capacity Of The Solvent Anion On The Thermal Stability Of Feruloyl Esterases In Ionic Liquid Systems
    标题:Dependency Of The Hydrogen Bonding Capacity Of The Solvent Anion On The Thermal Stability Of Feruloyl Esterases In Ionic Liquid Systems
    摘要:三种阿魏酸酯酶 Ec 3.1.1.73 (Fae),即来自黑曲霉的 Fae A (Anfaea),来自构巢曲霉的 Fae C (Andfaec) 以及来自特异腐质霉 (Ultraflo L) 的商业 β-葡聚糖酶混合物中的 Fae 活性测试了它们在四种离子液体(il)系统中催化芥子酸与甘油酯化的能力. Il 系统系统地由两对选定的阳离子和阴离子组成,分别为:[bmim][pf6],[c2Ohmim][pf6],[bmim][bf4] 和 [c2Ohmim][bf4]. Anfaea 在基于 [pf6] 的 Il 中具有活性,而 Ultraflo L 中的 Andfaec 和 Fae 没有明显的活性,并且在 Il 系统中通常不稳定. Il 系统中的 Fae 稳定性显然高度依赖于酶结构,值得注意的是 Anfaea 与 Il 相容性脂肪酶的相似性可以解释其稳定性. Anfaea 在缓冲液中的热稳定性高于 Il 系统,但在 40 oc 及以下,缓冲液和基于 [pf6]− 的系统之间 Anfaea 的稳定性没有显着差异:Anfaea置于[bmim] 中稳定][pf6] 和 [c2Ohmim][pf6] 系统在 40 oc 下反应 2 小时.然而,Il 阴离子对稳定性有重大影响:[bf4]− 导致 Anfaea 快速失活,而 [pf6]− 则不然.阳离子没有类似的效果.这些观察结果可以通过 Cosmo-Rs 模拟用 Il 阳离子和阴离子的氢键能力来解释.
    DOI:10.1039/c1Gc15115K

    海关参考信息

    专利信息


    专利号:US-2012190064-A1
    优先权日:2004-10-01
    标题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules
    发明人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA
    权利人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA; LIFE TECHNOLOGIES CORP
    摘要:Compositions, methods and kits for in vitro systems for synthesis of biomolecules such as polypeptides, are provided herein. Cell extracts that provide enhanced yields of soluble proteins using in vitro protein synthesis methods are provided. The invention also includes methods for producing high yields of proteins by the addition of a feeding solution that includes amino acids and an energy source to an ongoing in vitro synthesis system. The invention also includes methods of using a high-yield in vitro synthesis system to produce large quantities of proteins with incorporated labeled amino acids for analysis by methods such as by NMR. The invention further includes vectors for enhanced production of proteins from nucleic acid templates using in vitro synthesis systems.

    专利号:US-2024024489-A1
    优先权日:2020-11-20
    标 题:Protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof
    发明人:MULARD LAURENCE; DHARA DEBASHIS; PFISTER HELENE; PAOLETTI JULIE; PHALIPON ARMELLE; GUERREIRO-INVERNO CATHERINE
    权利人:PASTEUR INSTITUT
    摘要:The present invention provides zwitterionic oligosaccharides, in particular fragments of the surface polysaccharides from Shigella sonnei and Shigella sonnei conjugates comprising them. The present invention also provides protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof, the disaccharide repeating unit of Shigella sonnei being: (I)

    专利号:US-2023119068-A1
    优先权日:2020-02-13
    标题:Methods for rapid synthesis of pyranoanthocyanins
    发明人:ZHU XIAOYI; STRAATHOF NICOLE; MIYAGUSUKU-CRUZADO GONZALO; GIUSTI M MONICA; CANO ISRAEL GARCIA; JIMENEZ-FLORES RAFAEL
    权利人:OHIO STATE INNOVATION FOUNDATION
    摘要:The present disclosure provides methods for the rapid synthesis of pyranoanthocyanins.

    专利号:WO-2009033269-A1
    优先权日:2007-09-11
    标 题 :Novel polysaccharide immunogens from alloiococcus otitidis and synthesis of a glycoconjugate vaccine thereof
    发明人:MONTEIRO MARIO ARTUR; ARAR SARIF; HARIMAYA ATSUSHI
    权利人:UNIV GUELPH; MONTEIRO MARIO ARTUR; ARAR SARIF; HARIMAYA ATSUSHI
    摘要:The application relates to Alloiococcus otitidis cell surface polysaccharides, compositions comprising Alloiococcus otitidis cell surface polysaccharides, synthesis of a glycoconjugate vaccine and includes kits, methods and uses thereof.

    专利号:US-2025250302-A1
    优先权日:2024-02-05
    标题:Synthesis of self-assembling artificial proteins utilizing a host-guest system and uses thereof
    发明人:SANDANARAJ BRITTO S; KHYADE ASHWINI RAJENDRA; HATI KSHITISH CHANDRA
    权利人:INDIAN INSTITUTE OF SCIENCE EDUCATION AND RES PUNE IISER PUNE
    摘要:The invention relates to an efficient method for synthesizing self-assembling artificial proteins (SAPs) utilizing a catalytic host-guest system. The process involves encapsulating hydrophobic probes with cyclodextrin, performing site-specific protein bioconjugation, and employing a second catalysis cycle for enhanced labeling. SAPs produced through this method are versatile and find applications in therapeutic delivery and diagnostics. The process is simplified, scalable, cost-effective, and environmentally sustainable, addressing the challenges of traditional SAP synthesis. By offering improved yield, functionality, and structural integrity, this invention advances the potential of SAPs in medical and industrial fields.

    专利号:US-8647848-B2
    优先权日:2008-06-13
    标题:Enzymatic synthesis of sphingolipids
    发明人:HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS
    权利人:HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS; EVONIK GOLDSCHMIDT GMBH
    摘要:The invention relates to the enzymatic synthesis of sphingolipids and compositions that contain sphingolipids from lysosphingolipids and carbonic esters, and to cosmetic, dermatological or pharmaceutical formulations containing said sphingolipids or compositions.
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    主要参考文献

    [参考文献]: Quinn L, Et Al. Extraction And Quantification Of Sinapinic Acid From Irish Rapeseed Meal And Assessment Of Angiotensin-I Converting Enzyme (Ace-I) Inhibitory Activity. J Agric Food Chem. 2017 Aug 16;65(32):6886-6892.
    [参考文献]: Senawong T, Et Al. Histone Deacetylase (Hdac) Inhibitory And Antiproliferative Activities Of Phenolic-Rich Extracts Derived From The Rhizome Of Hydnophytum Formicarum Jack.: Sinapinic Acid Acts As Hdac Inhibitor. Bmc Complement Altern Med. 2013 Sep 22;13:232.
    [参考文献]: Zych M, Et Al. The Effects Of Sinapic Acid On The Development Of Metabolic Disorders Induced By Estrogen Deficiency In Rats. Oxid Med Cell Longev. 2018 Jun 4;2018:9274246.
    [参考文献]: Abhisek Chatterjee, Et Al. Dimethyl Sulphoxide And Ca2+ Stimulate Assembly Of Vibrio Cholerae Ftsz. Biochimie. 2014 Oct:105:64-75.
    [参考文献]: Arutselvan Natarajan, Et Al. Validation Of 64Cu-Dota-Rituximab Injection Preparation Under Good Manufacturing Practices: A Pet Tracer For Imaging Of B-Cell Non-Hodgkin Lymphoma. Mol Imaging. 2015:14.

    合成参考文献


    参考文献:10.1021/ja205783f
    摘要:Ökesli A, Cooper LE, Fogle EJ, van der Donk WA. Nine post-translational modifications during the biosynthesis of cinnamycin. J Am Chem Soc. 2011 Aug 31;133(34):13753–60.
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