专利号:US-6177564-B1 优先权日:1998-09-11 标题:Process for the synthesis of N-benzyl-3-(4-fluorophenyl)-1-4-oxazin-2-one 发明人:NELSON TODD D; BHUPATHY MAHADEVAN 权利人:MERCK & CO INC 摘要:The present invention is concerned with a novel process for the preparation of N-benzyl-3-(4-fluorophenyl)-1,4-oxazin-2-one of the formula:This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity, in particular, as substance P (neurokinin-1) receptor antagonists.
专利号:US-11680224-B2 优先权日:2020-11-04 标 题:Hydroxy fatty acid synthesis 发明人:CERMAK STEVEN C; Isbell Terry; LOWERY BENJAMIN A 权利人:US AGRICULTURE; THE US SECRATERY OF AGRICULTURE 摘要:The invention relates to methods for the synthesis of hydroxy fatty acids from unsaturated fatty acids via epoxidation and catalytic hydrogenation.
专利号:US-8557979-B2 优先权日:2004-06-10 标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation 发明人:CHOI WOO-BAEG; KOWALIK EWA 权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC 摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.
专利号:US-12159971-B2 优先权日:2020-12-11 标题 :Method of synthesis of solid electrolyte, a solid-state electrolyte composition, and an electrochemical cell 发明人:CARLSON BENJAMIN; CULVER SEAN P; IISENKER ILYA 权利人:SOLID POWER INC; SOLID POWER OPERATING INC 摘要:A method of synthesizing a solid-state electrolyte where P 2 S 5 , Na 2 S and LiCl are dissolved in one of more solvents; where upon reacting of the mixture, NaCl precipitates out and is removed from the solution; the solvent is removed; and the sulfide solid-state electrolyte is dried, then crystalized to be used in a solid-state battery. A solid-state battery comprising the produced sulfide solid-state electrolyte is also described.
专利号:US-2005209355-A1 优先权日:2004-03-22 标 题:[Novel Reactions and the Products of Such Reactions] 发明人:ROITMAN LIPA L 权利人:ROITMAN LIPA L 摘要:A process for the synthesis of novel compounds is described comprising reacting tetrachloroethylene with substances containing active methylene group in the presence of free radical initiators. Also, a process for grafting tetrachloroethylene is described comprising reacting these compounds with polymers containing active methylene group in the presence of free radical initiators. Furthermore, a method of conducting such reactions to high conversion is described, comprising conducting the reactions in the reflux condensate. The present invention provides a novel and high yield route for heretofore unobtainable materials.
专利号:US-5663480-A 优先权日:1993-12-20 标题:Synthesis of aromatic carbonates by transesterification using a catalyst comprising a microporous material and a group IV metal 发明人:TSUNEKI HIDEAKI; KIRISHIKI MASARU; WATANABE KENICHI; ONDA YOSHIYUKI 权利人:NIPPON CATALYTIC CHEM IND 摘要:A catalyst for producing an aryl ester of a carbonic or carboxylic acid is disclosed, which includes a microporous material containing a metal element belonging to group IV. This catalyst can be used as a heterogeneous catalyst to produce the aryl ester in high yield with industrial advantages. In order to produce the aryl ester using the catalyst, a carbonate or an aliphatic carboxylate is transesterified with an aromatic hydroxy compound, or an aryl carboxylate is transesterified with a carbonate, or an alkyl aryl carbonate is disproportionated by transesterification.
摘要:Acute Toxicity Data. Journal of the American College of Toxicology, Part B., 1(192), 1992 摘要:Santana, V. C. S.; Munaretto, L. S.; de Lucca, E. C., Jr., Science of Synthesis Knowledge Updates, (2022) 1, 204. 摘要:Hudson, R.; Moores, A., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2017) 1, 73. 摘要:Food and Cosmetics Toxicology., 18(661), 1980