专利号:US-2025179012-A1 优先权日:2022-03-04 标 题:Synthesis of sulfur(vi) compounds and reagents for same 发明人:LOPCHUK JUSTIN MATTHEW; SHULTZ ZACHARY 权利人:H LEE MOFFITT CANCER CT & RES 摘要:This disclosure provides reagents and processes for the synthesis of organic compounds, more particularly reagents and processes for the asymmetric synthesis of sulfur (VI) containing organic compounds.
专利号:US-5231198-A 优先权日:1992-07-06 标题:Asymmetric synthesis of hexahydrodibenzofurans by stereospecific inversion of ortho substituted 2-phenylcyclohexanols 发明人:POWERS MATTEW R; GOLEC FREDERICK A 权利人:RHONE POULENC RORER PHARMA 摘要:This invention relates to the stereospecific process for the preparation, separation and purification of hexahydrodibenzofurans which are used in the preparation of the 5HT 3 compounds. More specifically, the present invention relates to a process for the preparation of substantially optically pure cishexahydrodibenzofuran compounds including at least two chiral fused ring centers which comprises the acidic catalyzed stereospecific ring closure by the intra-molecular inversion of a gamma, i.e. 2', carbon atom of a 2-[(2'-leaving group)cycloalkyl]phenol.
专利号:US-6268499-B1 优先权日:1998-08-10 标 题 :Process and intermediates for preparation of substituted piperidine-epoxides 发明人:GUELLER ROLF; LOHRI BRUNO; SCHMID RUDOLF 权利人:HOFFMANN LA ROCHE 摘要:The present invention concerns intermediates useful in and a process for the preparation of a compound of formula 1 or a salt thereof n comprisingepoxidation of a compound of formula 2 or a salt thereof n wherein A, R 1 and R 2 are as herein defined. These compounds are useful in the synthesis of renin inhibitors.
专利号:US-6274735-B1 优先权日:1998-08-10 标 题 :Process and intermediates for preparation of substituted piperidines 发明人:LOHRI BRUNO; SCHMID RUDOLF; VIEIRA ERIC 权利人:HOFFMANN LA ROCHE 摘要:The present invention concerns intermediates useful in and a process for the preparation of a compound of formula 1 or a salt thereof n comprising n a) hydroboration of a compound of formula 2 n A, R 1 and R 2 are as herein defined. These compounds are useful in the synthesis of renin inhibitors.
专利号:US-5136085-A 优先权日:1990-11-28 标 题 :Synthesis of 2-aminobenzophenones 发明人:JOHNSON MARTY C; FRYE STEPHEN V 权利人:GLAXO INC 摘要:Process for synthesizing 2-aminobenzophenones such as the following formula (I): (I) wherein X1 and X2 are substituents and r and s are 1 or 2, by reacting an anthranilic acid amide e.g. an N-alkoxy-N-alkyl anthranilic acid amide, with a halobenzene in the presence of an alkyllithium reagent.
专利号:US-5053543-A 优先权日:1990-11-28 标 题 :Synthesis of 2-aminobenzophenones 发明人:JOHNSON MARTY C; FRYE STEPHEN V 权利人:GLAXO INC 摘要:Process for synthesizing 2-aminobenzophenones such as the following formula (I): (I) wherein X1 and X2 are substituents and r and s are 1 or 2, by reacting an anthranilic acid amide e.g. an N-alkoxy-N-alkyl anthranilic acid amide, with a halobenzene in the presence of an alkyllithium reagent.
[参考文献]: K Suzuki, Et Al. 2-Arylmethyl-1,4-Benzoquinones. Ii. Novel Inhibitors Of Platelet Aggregation: Synthesis And Pharmacological Evaluation. Chem Pharm Bull (Tokyo). 1997 Apr;45(4):668-74. [参考文献]: Mingzhang Gao, Et Al. Synthesis And Preliminary Biological Evaluation Of New Carbon-11 Labeled Tetrahydroisoquinoline Derivatives As Serm Radioligands For Pet Imaging Of Er Expression In Breast Cancer. Eur J Med Chem. 2008 Oct;43(10):2211-9.
合成参考文献
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