CAS: 76801-93-9; 5-Amino-N1,N3-Bis(2,3-Dihydroxypropyl)-2,4,6-Triiodoisophthalamide

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CAS号76820-35-4 5-氨基-NN′-双(2.3-... | CAS号76820-34-3 N,N'-双(2,3-二羟丙基... | CAS号99-31-0 5-氨基间苯二甲酸 | CAS号35453-19-1 5-氨基-2,4,6-三碘间苯二甲酸 | CAS号13290-96-5 5-硝基间苯二甲酸二甲酯 | CAS号616-30-8 3-氨基-1,2-丙二醇 | CAS号37441-29-5 5-氨基-2,4,6-三碘异酞酰氯 | CAS号31127-80-7 5-乙酰氨基-N,N'-双(2...

5-硝基-N,N'-双(2,3-二羟基丙基)-1,3-苯二甲酰胺置于sodium Tetrahydroborate,水,一氯化碘体系中,化学反应生成 5-氨基-2,4,6-三碘-N,N'-二(2,3-二羟基丙基)-1,3-苯二甲酰胺
参考文献:离子液体功能化纤维素 (Au@cil) 上负载的金纳米颗粒:用于选择性还原芳香族硝基化合物的非均相催化剂
标题:离子液体功能化纤维素 (Au@cil) 上负载的金纳米颗粒:用于选择性还原芳香族硝基化合物的非均相催化剂
摘要:为了响应对绿色和具有成本效益的催化剂日益增长的需求,已经合成了一种在许多环境友好型应用中有效的新型生物质衍生的非均相催化剂.非均相催化剂 (Au@cil) 由嵌入金纳米粒子 (Nps) 的离子液体功能化纤维素组成,用于选择性还原硝基.au Nps 由 Au 3+还原为au 0形成与抗坏血酸同时嵌入固体支持系统.使用红外光谱,粉末 X 射线衍射,扫描电子显微镜,Zeta 电位测量,能量色散 X 射线分析,元素点映射和原子力显微镜证实了嵌入的 Au Nps 的存在.在 30 oc 的水中,多相催化剂au@cil在其他官能团(如羟基,氨基,醛,羧酸和酰胺)存在下选择性地将芳香族硝基化合物转化为相应的胺.
DOI:10.1002/aoc.6855

专利信息

专利号:US-8969619-B2
优先权日:2009-07-21
标题:Synthesis of iodixanol in propyleneglycol
发明人：JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; KJERNLI TROND; HOMESTAD OLE MAGNE
权利人:JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; KJERNLI TROND; HOMESTAD OLE MAGNE; GE HEALTHCARE AS
摘要:This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with propyleneglycol as solvent.

专利号:WO-9316981-A1
优先权日:1992-02-28
标 题:Synthesis of ioversol using a minimal excess of acetoxyacetylchloride
发明人：MC CARTHY WILLIAM Z; KNELLER MILLS THOMAS; LIN YOULIN; WALLACE REBECCA ABERNATHY; WHITE DAVID HILL
权利人:MALLINCKRODT MEDICAL INC
摘要:The use of a minimal excess of acetoxyacetylchloride as a reagent in the synthesis of N, N'-bis (2,3-dihydroxypropyl)-5-N-(2-hydroxyethyl)glycolamido-2,4,6-triiodoisophthalamide.

专利号:US-2011021821-A1
优先权日:2009-07-21
标题:Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
发明人：CERVENKA JAN; HUSSAIN KHALID
权利人:GE HEALTHCARE AS
摘要:This invention relates to an improved method for the synthesis of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound Aâ€?), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a continuous process of acetylation of 5-amino-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide (“Compound Bâ€?) followed by the removal of acetic anhydride.

专利号:US-5177261-A
优先权日:1991-07-22
标题 :Synthesis of ioversol using chloroacetyl chloride
发明人：MCCARTHY WILLIAM Z; KNELLER MILLS T; LIN YOULIN; WHITE DAVID H
权利人:MALLINCKRODT MEDICAL INC
摘要:The use of chloroacetylchloride as an alternative or substitute reagent for acetoxychloride in the synthesis of N,N'- bis (2,3-dihydroxypropyl)-5-N-(2-hydroxyethyl)glycolamido-2,4,6-triiodoisophthalamide.

专利号:US-7696381-B1
优先权日:2009-07-21
标题 :Alternative dimerisation reagents for synthesis of iodixanol
发明人：BERG ARNE; DUGSTAD HARALD; GACEK MICHEL; GULBRANDSEN TRYGVE; STRANDE PER
权利人:GE HEALTHCARE AS
摘要:This invention relates generally to non-ionic X-ray contrast agents. It further relates to the synthesis of iodixanol. In particular, it relates to alternative dimerisation reagents in the conversion of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound Aâ€?) to iodixanol.

专利号:US-8962886-B2
优先权日:2009-07-21
标题:Synthesis of iodixanol in methanol
发明人：JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; HOMESTAD OLE MAGNE
权利人:JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; HOMESTAD OLE MAGNE; GE HEALTHCARE AS
摘要:This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with methanol as solvent.