CAS: 14109-72-9; 1-(Methylthio)Propan-2-One

相似化合物

6943-87-9 13678-58-5 20996-62-7

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CAS号74-93-1 甲硫醇 | CAS号78-95-5 氯丙酮 | CAS号64127-51-1 methyl 4-methyl... | CAS号106-47-8 对氯苯胺 | CAS号35928-65-5 2-methylsulfany... | CAS号917-65-7 甲基二氯化铝 | CAS号598-31-2 溴丙酮 | CAS号5188-07-8 甲硫醇钠 | CAS号36832-54-9 (2-methoxy-ally... | CAS号67-56-1 甲醇 | CAS号5000-46-4 甲磺酰乙酮 | CAS号170806-10-7 6,7-dichloro-3-... | CAS号850785-50-1 6-甲氧基-2-甲基-3-(甲... | CAS号6943-87-9 1-(甲基硫烷基)丙-2-醇 | CAS号50450-24-3 chloromethyl(2-... | CAS号56870-03-2 1-chloro-1-meth... | CAS号40015-20-1 ethyl 2-methyl-...

α-Methylmercaptopropionamidine置于硫酸体系中,化学反应生成1-甲基硫代-2-丙酮
参考文献:Kirrmann,A. Et Al.,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1962,Vol. 255,P. 728-730
标题:Kirrmann,A. Et Al.,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1962,Vol. 255,P. 728-730

专利信息

专利号:US-2006257560-A1
优先权日:2004-12-30
标 题 :Polymer surfaces for insitu synthesis of polymer arrays
发明人：BARONE ANTHONY D; LI HANDONG; MCGALL GLENN H
权利人:AFFYMETRIX INC
摘要:In one aspect of the present invention polymers are used to create films providing three-dimensional array substrates. The films were stable and presented good hydroxyl group numbers as compared with arrays without polymer films. It is an object of the present invention that three dimensional arrays substrates provide a means to obtain higher density polymer arrays.

专利号:US-3901899-A
优先权日:1973-04-27
标题 :Synthesis of indoles from anilines and intermediates therein
发明人：GASSMAN PAUL G
权利人:UNIV OHIO STATE RES FOUND
摘要:Preparing indoles and intermediates therefor by reacting an Nhaloaniline with a Beta -carbonylic hydrocarbon sulfide to form an azasulfonium halide, reacting the azasulfonium halide with a strong base to form a thio-ether indole derivative, and then reducing the thio-ether indole, e.g. with Raney nickel, to form the indole compound. When an acetal or ketal of the Beta carbonyl hydrocarbon sulfide is used, the azasulfonium salt is treated with a base, and then with an acid to form the thio-ether indole derivative. When an Alpha -ethyl- Beta -carbonylic hydrocarbon sulfide is used, the resulting azosulfonium salt reacts with strong base to form a thio-ether indolenine derivative, which on reduction with Raney nickel or complex metal hydrides yields 3-substituted indoles. The aniline may be an aminopyridine to form an aza-indole compound in the process. The azasulfonium salts and thio-ether indole or thio-ether indolenine derivatives can be isolated and recovered from their respective reaction mixtures. The thio-ether-indole and thio-ether indolenine derivatives are useful as intermediates to make the indoles without the thio-ether group. The indoles are known compounds having a wide variety of uses, e.g., in making perfumes, dyes, amino acids, pharmaceuticals, agricultural chemicals and the like.

专利号:EP-0051792-A1
优先权日:1980-11-08
标 题 :Derivatives of hydroxamic-acid esters, process for their preparation and their use as herbicides
发明人：FUEHRER WOLFGANG DR; STETTER JOERG DR; EUE LUDWIG DR; SCHMIDT ROBERT RUDOLF DR
权利人:BAYER AG
摘要:Hydroxamic acid derivatives of the formula in which Y represents oxygen or sulfur, R¹ represents hydrogen, alkyl or alkoxy, R² represents hydrogen, alkyl, alkoxy or halogen, R³ represents hydrogen, alkyl, alkoxy or halogen, R < 4> represents hydrogen or alkyl, R <5> represents alkyl, alkenyl, alkynyl or alkoxyalkyl, R <6> represents hydrogen, alkyl, alkenyl, alkynyl or alkoxyalkyl or R <4> and R <5> together represent one Alkylene chain, or R 5 and R 6 together represent an alkylene chain, provided Y is oxygen and Z is halogen, a process for their preparation and their use as herbicides. N-phenylglycine derivatives of the formula in which Y, R¹, R², R³, R <4>, R <5> and R <6> have the meanings given above, several processes for their preparation and their use as intermediates for the synthesis of the substances of formula (I).

专利号:US-3992392-A
优先权日:1973-04-27
标题:Synthesis of indoles from anilines and intermediates therein
发明人：GASSMAN PAUL G
权利人:UNIV OHIO STATE RES FOUND
摘要:Preparing indoles and intermediates therefor by reacting an N-haloaniline with a β-carbonylic hydrocarbon sulfide to form an azasulfonium halide, reacting the azasulfonium halide with a strong base to form a thio-ether indole derivative, and then reducing the thio-ether indole, e.g. with Raney nickel, to form the indole compound. When an acetal or ketal of the β-carbonyl hydrocarbon sulfide is used, the azasulfonium salt is treated with a base, and then with an acid to form the thio-ether indole derivative. When an α-ethyl-β -carbonylic hydrocarbon sulfide is used, the resulting azosulfonium salt reacts with strong base to form a thio-ether indolenine derivative, which on reduction with Raney nickel or complex metal hydrides yields 3-substituted indoles. The aniline may be an aminopyridine to form an aza-indole compound in the process. The azasulfonium salts and thio-ether indole or thio-ether indolenine derivatives can be isolated and recovered from their respective reaction mixtures. The thio-ether-indole and thio-ether indolenine derivatives are useful as intermediates to make the indoles without the thio-ether group. The indoles are known compounds having a wide variety of uses, e.g., in making perfumes, dyes, amino acids, pharmaceuticals, agricultural chemicals and the like.

专利号:US-8927485-B2
优先权日:2010-02-18
标题:Site-specific modification of proteins through chemical modification enabling protein conjugates, protein dimer formation, and stapled peptides
发明人：KRANTZ ALEXANDER; YU PENG
权利人:KRANTZ ALEXANDER; YU PENG; ADVANCED PROTEOME THERAPEUTICS INC
摘要:The present invention generally provides methods for the site-specific modification of peptides, polypeptides, and proteins, e.g., granulocyte macrophage colony-stimulating factor, human superoxide dismutase, annexin, leptin, antibodies and the like, cytokines and chemokines, at their N-termini and at sites at which unnatural aminoacids have been introduced along the protein framework. The modifications described herein can be used for the synthesis and application of the adducts in radio-labeling, molecular imaging and protein therapeutic applications, and the treatment of disorders such as rheumatoid arthritis, lupus erythematosus, psoriasis, multiple sclerosis, type-1 diabetes, Crohn's disease, and systemic sclerosis, Alzheimer disease, cancer, liver disease (e.g., alcoholic liver disease), and cachexia.

专利号:US-9090629-B2
优先权日:2010-11-03
标题:Cytotoxic agents comprising new ansamitocin derivatives
发明人：CHARI RAVI V J; WIDDISON WAYNE C; WILHELM SHARON D
权利人:CHARI RAVI V J; WIDDISON WAYNE C; WILHELM SHARON D; IMMUNOGEN INC
摘要:New ansamitocin derivatives bearing a linking group are disclosed. Also disclosed are methods for the synthesis of these new ansamitocin derivatives and methods for their linkage to cell-binding agents. The ansamitocin derivative-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.