CAS: 152520-56-4; Nebivolol Hydrochloride

上下游产品

[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-((R)-6-fluoro-chroman-2-yl)-ethyl]-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-2-((S)-6-fluoro-chroman-2-yl)-ethyl]-amine 6-fluoro-(2R)-2-[(2R)-2-oxiranyl]-3,4-dihydrobenzopyran (R)-2-amino-1-[(S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]ethanol 4-Fluorophenol

专利信息

专利号:WO-2013018053-A1
优先权日:2011-08-02
标题 :Process for the preparation of epoxides as intermediates for the synthesis of nebivolol
发明人：CIPOLLONE AMALIA; D ANDREA PIERO; FATTORI DANIELA
权利人:MENARINI INT OPERATIONS LU SA; CIPOLLONE AMALIA; D ANDREA PIERO; FATTORI DANIELA
摘要:The present invention relates to a novel process of synthesis of epoxides, 6-fluoro-2- (oxiran-2-yl) chroman (Figure 1), intermediates for the synthesis of nebivolol, depicted in Scheme (1), enabling to obtain the above- mentioned epoxides in a racemic or semichiral form.

专利号:US-10392361-B2
优先权日:2016-01-21
标题:Process for the synthesis of intermediates of Nebivolol
发明人：BARTOLI SANDRA; MANNUCCI SERENA; GRISELLI ALESSIO; STEFANINI ALESSIO
权利人:MENARINI INT OPERATIONS LUXEMBOURG SA
摘要:The present invention relates to a novel process for the synthesis of the intermediate compounds constituted by chromanyl haloketones of formula III and 6-fluoro-2-(oxiran-2-yl)chromans of formula I. n The intermediates thus obtained can be used for the synthesis of Nebivolol.

专利号:EP-2163551-B1
优先权日:2008-09-08
标题 :An improved process for the preparation of nebivolol hydrochloride
发明人：KHAMAR BAKULESH MAFATLAL; THAKOR INDRAJIT; PATEL MAHESH; JADAV KALPESH; PARIKH ANKUR; JOSHI ATUL CHHOTALAL; PONNAIAH RAVI; MODI INDRAVADAN AMBALAL
权利人:CADILA PHARMACEUTICALS LTD
摘要:The present invention provides an improved process for the synthesis of Nebivolol and its pharmaceutically acceptable salts, more particularly hydrochloride salt of formula (I). Invention involves one pot synthesis of Nebivolol from epoxy monomer, which proceeds stereo specifically in high yield, without isolation of benzylated Nebivolol intermediate or its purification and does not require an additional purification of final compound.

专利号:US-8785664-B2
优先权日:2010-02-11
标 题 :Process for the preparation of nebivolol
发明人：BARTOLI SANDRA; CIPOLLONE AMALIA; FATTORI DANIELA
权利人:MENARINI INT OPERATIONS LU SA
摘要:The present invention relates to a novel process for the synthesis of Nebivolol product represented in Scheme (1), comprised of a reduced number of high-yield steps, and characterized by the kinetic resolution of the two epoxide pairs diastereoisomeric therebetween (mixture 1), allowing to avoid complex chromatographic separations.

专利号:US-8487122-B2
优先权日:2010-02-11
标题 :Process for the preparation of nebivolol
发明人：BARTOLI SANDRA; CIPOLLONE AMALIA; FATTORI DANIELA
权利人:BARTOLI SANDRA; CIPOLLONE AMALIA; FATTORI DANIELA; MENARINI INT OPERATIONS LU SA
摘要:The present invention relates to a novel process for the synthesis of Nebivolol product represented in Scheme (1), comprised of a reduced number of high-yield steps, and characterized by the kinetic resolution of the two epoxide pairs diastereoisomeric therebetween (mixture 1), allowing to avoid complex chromatographic separations.

专利号:US-2011250454-A1
优先权日:2010-04-09
标 题:Preparation of nebivolol
发明人：HALDAR PRANAB; GOLLA CHINA MALAKONDAIAH; SWAPNA AKULA; KUMAR KARRI VIJAYA; JAWLEKAR SUHAS; TUMMALA ARJUN KUMAR; PATRO DEEPALI; YARRAGUNTLA SESHA REDDY; RAMAKRISHNAN SRIVIDYA; CHIMALA VENKATA RAMANA REDDY
权利人:HALDAR PRANAB; GOLLA CHINA MALAKONDAIAH; SWAPNA AKULA; KUMAR KARRI VIJAYA; JAWLEKAR SUHAS; TUMMALA ARJUN KUMAR; PATRO DEEPALI; YARRAGUNTLA SESHA REDDY; RAMAKRISHNAN SRIVIDYA; CHIMALA VENKATA RAMANA REDDY
摘要:Processes for the synthesis of pharmacologically active 2,2-iminobisethanol derivatives, e.g., 2H-1-benzopyran-2 methanol-α,α′-iminobis(methylene)]bis-[6-fluoro-3,4-dihydro-[2R*[R*[R*(S*)]]]], and their pharmaceutically acceptable salts.