(二氯亚甲基)二磷酸四异丙酯置于potassium Fluoride,18-冠醚-6体系中,用 乙腈 用作溶剂,化学反应 168.0H,以60%的收率获得亚甲基二磷酸四异丙酯 参考文献:Hutchinson,D. W.; Semple,G.,Phosphorus And Sulfur And The Related Elements,1984,Vol. 21,P. 1-4 标题:Hutchinson,D. W.; Semple,G.,Phosphorus And Sulfur And The Related Elements,1984,Vol. 21,P. 1-4
专利号:US-3772412-A 优先权日:1971-06-28 标题 :Hypohalogenation of gem-diphosphonate esters and phosphonoacetate esters 发明人:QUIMBY O; PRENTICE J 权利人:PROCTER & GAMBLE 摘要:A PROCESS FOR THE PRODUCTION OF MONO- AND DIHALOGENEATED GEM-DIPHOSPHONATE ESTERS (C3-C8) AND MONOAND DIHALOGENTAED PHOSPHONOACETATE ESTERS (C5-C7) IS DISCLOSED. DIBROMINATED AND DIIODATED GEM-DIPHOSPHONATE ESTERS CONTAINING ALKYL GROUPS HAVING THREE TO EIGHT CARBON ATOMS, DICHLORINATED GEM-DIPHOSPHONATE ESTERS CONTAINING ALKYL GROUPS HAVING FROM 7 TO 8 CARBON ATOMS, AND MONOHALOGENATED GEM-DIPHOSPHONATE ESTERS CONTAINING ALKYL GROUPS HAVING FROM 7 TO 8 CARBON ATOMS, AS NOVEL COMPOUNDS, ARE ALSO DISCLOSED. THE GEM-DIPHOSPHONATE ESTERS ARE USEFUL AS INTERMEDIATES IN THE SYNTHESIS OF DETERGENT BUILDERS AND AS EXTREME PRESSURE AND ANTI-WEAR ADDITIVIES IN LUBRICANT CMPOSITIONS. THE PHOSPHONOACETATE ESTERS ARE USEFUL AS EXTREME PRESSURE AND ANTI-WEAR ADDITIVIES IN LUBRICANT CMPOSITIONS.
专利号:US-5442085-A 优先权日:1992-12-04 标 题:Synthesis of tetraalkyl vinylidene diphosphonate monomer 发明人:ALEXANDRATOS SPIRO D 权利人:UNIV TENNESSEE RES CORP 摘要:A method of making a monomer of tetraalkyl vinylidene-1, 1-diphosphonate. The monomer is manufactured by combining an aqueous secondary amine solution with a formaldehyde and a tetra (alkyl) methylene diphosphonate. The resulting mixture is maintained at a pH above about 6 and refluxed for two hours to enable reaction to produce the monomer of tetraalkyl vinylidene-1, 1-diphosphonate. The product monomer is then purified to produce the final end product.
专利号:WO-2010135167-A1 优先权日:2009-05-18 标 题:Copolyelectrolyte monomers bearing multiple acid groups 发明人:GOLDBACH JAMES T; BRETECHE GUILLAUME; CALLET GREGORY J P; WAN XIAOBO; MOUNTZ DAVID A 权利人:ARKEMA INC; GOLDBACH JAMES T; BRETECHE GUILLAUME; CALLET GREGORY J P; WAN XIAOBO; MOUNTZ DAVID A 摘要:The invention relates to the polymerization and copolymerization of aryl-containing monomers containing two or more acid groups. These polymers and copolymers are useful as copolyelectrolytes, and can be effectively blended with other polymers to form membranes. These membranes are useful under hydrated conditions, and may find use as membranes in fuel cells, water purification, humidification and battery separators. The invention also relates to a novel means of synthesizing certain diacid aryl monomers, useful in the synthesis of the copolyelectrolytes.
专利号:US-12163172-B2 优先权日:2023-05-03 标题 :Reagents and methods used in deprotection of 3'-O-amino polynucleotides 发明人:APARIN ILYA; SOSKINE MIKHAEL; WU WEIDONG; VEILLET ADELINE 权利人:DNA SCRIPT 摘要:This disclosure relates to an enzymatic method of synthesizing a polynucleotide, comprising a deprotecting step which uses as a deprotecting agent a specific phosphonate compound. It also pertains to a method for deprotecting 3′-O-amino elongated fragments of a polynucleotide in an enzymatic method of synthesizing a polynucleotide, comprising contacting the elongated fragments with this phosphonate compound. This disclosure further relates to a kit for synthesizing a polynucleotide comprising one or more vials of synthesis reagents, at least one of which contains an effective amount of a phosphonate compound and to a specific method for preparing said phosphonate compound.
专利号:WO-2012013168-A1 优先权日:2010-07-29 标题 :Method of the synthesis of dialkyl haloalkylphosphonates and dialkyl haloalkyloxyalkylphosphonates
专利号:EP-2598509-A1 优先权日:2010-07-29 标题 :Method of the synthesis of dialkyl haloalkylphosphonates and dialkyl haloalkyloxyalkylphosphonates
[参考文献]: L Gil, Et Al. Prostaglandin E2-Bisphosphonate Conjugates: Potential Agents For Treatment Of Osteoporosis. Bioorg Med Chem. 1999 May;7(5):901-19.
合成参考文献
参考文献:10.1039/b915468j 摘要:Heuclin H, Grünstein D, Le Goff XF, Le Floch P, Mézailles N. Phosphorus stabilized carbene complexes: bisphosphonate dianion synthesis, reactivity and DFT studies of O~C~O zirconium(IV) complexes. Dalton Trans. 2010 Jan 14;(2):492–9. doi: 10.1039/b915468j. 摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).