CAS: 539-74-2; Ethyl 3-Bromopropanoate

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CAS号140-88-5 丙烯酸乙酯 | CAS号623-71-2 3-氯丙酸乙酯 | CAS号41330-13-6 1,1-diethoxycyc... | CAS号590-92-1 3-溴丙酸 | CAS号64-17-5 乙醇 | CAS号57-57-8 丙内酯 | CAS号107-13-1 丙烯腈 | CAS号186581-53-3 重氮甲烷 | CAS号105-36-2 溴乙酸乙酯 | CAS号109179-39-7 ethyl 3-phenyls... | CAS号3699-67-0 3-膦酰丙酸三乙脂 | CAS号74-96-4 溴乙烷 | CAS号140-88-5 丙烯酸乙酯 | CAS号32806-70-5 2-丙基-2-(乙氧羰基)戊二酸二乙酯 | CAS号35979-69-2 4-溴-2-甲基-2-丁醇 | CAS号5439-14-5 3,4-二氢-2H-吡啶并[1... | CAS号4911-54-0 4-甲基-4-戊烯酸乙酯 | CAS号43032-38-8 3-(哌嗪-1-基)丙 酸乙酯 | CAS号142403-34-7 ethyl 3-(5-hydr...

丙烯酸乙酯置于2-甲基-2-丁烯,三甲基溴硅烷,氧气,Copper(I) Bromide体系中,用 二氯甲烷,水 作为反应溶剂,以80%的收率获得产物3-溴丙酸乙酯
参考文献:铁(II)和铜(i)控制烯烃氢溴化反应的总区域选择性
标题:铁(II)和铜(i)控制烯烃氢溴化反应的总区域选择性
摘要:描述了一种可以完全控制烯烃氢溴化反应的区域选择性的新方法.在此,我们报告了一种使用 Tmsbr 和氧作为常用试剂的自由基过程,其中在存在百万分之几的 Cu(I) 物种的情况下,反马尔可夫尼科夫产物的形成发生,而马尔可夫尼科夫产物的形成发生在存在 30 Mol% 的溴化铁 (II).密度泛函理论计算结合福井的激进磁化率支持获得的结果.
DOI:10.1021/acs.Orglett.1C02186

专利信息

专利号:US-5990341-A
优先权日:1993-11-08
标 题 :Diastereoselective synthesis hydroxyethylene dipeptide isosteres
发明人：LIOTTA DENNIS C; LAGU BHARAT RAMKRISHNA
权利人:UNIV EMORY
摘要:A process for the synthesis of hydroxyethylene dipeptide isosteres from α-N,N-di(protected)amino(alkyl or substituted alkyl) methyl ketones that can be efficiently carried out on an industrial scale. The process proceeds with excellent diastereoselectivity and chemical efficiency, and can be used to prepare a wide variety of hydroxyethylene dipeptide isosteres for a variety of uses, including as HIV-1 protease inhibitors and renin inhibitors.

专利号:US-11560357-B2
优先权日:2018-09-22
标题 :Methods of producing pyrazole compounds
发明人：GUPTA RAMESH CHANDRA; SINGARAVEL MOHAN; CHHIPA LAXMIKANT; KASUNDRA ASHOK
权利人:TORRENT PHARMACEUTICALS LTD
摘要:The present invention is directed to methods of producing substituted pyrazole based compounds through novel intermediates and unique processes for preparing such intermediates which enables synthesis of final product through commercially viable route of synthesis. The present invention is also directed to novel methods of producing substituted pyrazole based thyroid like compounds, and solid forms of 3-{4-[(7-hydroxy-6-methyl-indan-4-yl)methyl]-3,5-dimethyl-1H-pyrazol-1-yl}-propanoic acid, its pharmaceutical compositions, and methods of preparation thereof.

专利号:US-2003144441-A1
优先权日:2001-11-13
标题 :Controlled copolymerization of methyl acrylate with olefins under mild conditions
发明人：SEN AYUSMAN; ELYASHIV-BARAD SHARON; LIU SHENGSHENG
摘要:A copper-mediated process for the synthesis of random copolymers of methyl acrylate with non-polarolefins, ranging from ethene to 1-octene, norbornene and norbornene derivatives, and capable of synthesizing copolymers having greater than 5% incorporation of the olefin, as well as copolymers synthesized using the process are described. The process displays many of the characteristics of a living polymerization process: the polydispersities of the copolymers obtained are less than about 1.7, preferably from about 1.1 to about 1.4, and it is possible to synthesize novel block terpolymers of methyl acrylate with olefins by the sequential addition of the latter monomers.

专利号:US-8653238-B2
优先权日:2006-02-27
标题:Compositions and methods for transport of molecules with enhanced release properties across biological barriers
发明人：WENDER PAUL A; GOUN ELENA A; JONES LISA R
权利人:WENDER PAUL A; GOUN ELENA A; JONES LISA R; UNIV LELAND STANFORD JUNIOR
摘要:Conjugates of a cargo molecule with a transporter molecule are disclosed, where the cargo molecule and the transporter molecule are linked covalently by a releasable linker. The cargo of the conjugate can be a biologically active agent or a reporter molecule. The transporter modulates the transport of the cargo across a biological barrier (e.g., a cell membrane) compared to the transport of the unconjugated cargo. Releasable linkers suitable for rapid and facile conjugation to various types of cargo and transporters are also disclosed, along with methods for using the linkers in the synthesis of conjugates.

专利号:US-11512097-B2
优先权日:2019-11-25
标题 :Heterocyclic compounds as Delta-5 desaturase inhibitors and methods of use
发明人：ALLEN JENNIFER R; BELTRANI MICHELA; BOURBEAU MATTHEW P; DAMYANOVA TEODORA P; LINGARD IAIN; MINATTI ANA E; VINCETTI PAOLO
权利人:AMGEN INC
摘要:The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase (“D5Dâ€?). The compounds have a general Formula I n nwherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:WO-2008148560-A1
优先权日:2007-06-07
标题 :New hybrid compounds of nucleobases and organic redox molecules and their use
发明人：ASAFTEI SIMONA CARMEN
权利人:UNIV OSNABRUECK; ASAFTEI SIMONA CARMEN
摘要:The present invention relates to new compounds as well as methods for the synthesis of the same, said compounds comprise a redox active group, e.g. a 4,4-bipyridine (viologen), a 1,2-di(4-pyridyl)ethane, a 2,7-diazapyrene or 2,9-diazaperylene group and a N-heterocyclic nucleobase (HB), also referred to as base.