专利号:US-9597327-B2 优先权日:2005-05-25 标 题:Synthesis of (R)-N-methylnaltrexone 发明人:DOSHAN HAROLD D; PEREZ JULIO 权利人:PROGENICS PHARM INC 摘要:This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.
专利号:US-2024082118-A1 优先权日:2021-05-19 标 题:Topical compositions and methods of preparing the same 发明人:ABRAMOVICH SAGI; AVIDOR GAL; LANDA BENZION 权利人:LANDA LABS 2012 LTD 摘要:There is disclosed a composition comprising a water-insoluble thermoplastic compound capable of stimulating collagen synthesis (CSSC), the CSSC having a molecular weight of more than 0.6 kDa and being dispersed in a polar carrier as nano-elements having an average diameter of 200 nm or less and a viscosity of 107 mPa·s or less. The nano-elements of CSSC can be capable of stimulating the synthesis of skin proteins and/or enabling the delivery of active agents upon their application to a surface to be treated therewith. Methods for preparing the compositions and uses thereof are also provided.
专利号:EP-2354120-A1 优先权日:2003-08-20 标题 :Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof 发明人:GALLOP MARK A; YAO FENMEI; LUDWIKOW MARIA J; PHAN THU; PENG GE 权利人:XENOPORT INC 摘要:The present invention relates to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-tluorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The present invention also relates to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
专利号:US-2023285442-A1 优先权日:2020-03-26 标题 :Use of oligochitosans and derivatives thereof for neutralizing viral agents 发明人:MOHAPATRA SUBHRA; MOHAPATRA SHYAM S; Garay Julio; HANNA MAZEN; MAYILSAMY KARTHICK 权利人:MOHAPATRA SUBHRA; MOHAPATRA SHYAM S; Garay Julio; HANNA MAZEN; MAYILSAMY KARTHICK 摘要:Described herein are methods for neutralizing a virus. The methods involve interacting the virus with an oligochitosan or a derivative thereof having a molecular weight of at least 1 KDa and a degree of deacetylation of at least 1%. The methods described herein have numems applications with respect to the treatment or prevention of viral infections caused by a human immunodeficiency virus, a paramyxovirus, an orthomyxovirus, a coronavirus, or a filovirus as well as the detection and quantification of viral load. Also described herein are the synthesis of the oligochitosan and derivatives thereof.
专利号:US-11850220-B2 优先权日:2020-05-19 标题 :Synthesis of ibuprofen hybrid conjugates as anti-inflammatory and analgesic agents 发明人:PANDA SIVA 权利人:UNIV RES INST INC AUGUSTA 摘要:Disclosed herein as ibuprofen hybrid conjugates and methods of their use to reduce inflammation, pain, and fever. The ibuprofen conjugates have potent anti-inflammatory and analgesic properties with low potential for ulcerogenic activity. An exemplary compound is an ibuprofen-amino acid-4-aminophenol hybrid. Also disclosed are methods of treating or reducing inflammation, pain, and fever in a subject.
专利号:WO-2015179088-A1 优先权日:2014-05-22 标题 :Conversion of 5-(halomethyl)-2-furaldehyde into polyesters of 5-methyl-2furoic acid 发明人:CAHANA AVIAD; MARTIN TIMOTHY J; GEORGE TIMOTHY R 权利人:XF TECHNOLOGIES INC 摘要:The present invention provides methods of synthesis of di-, tri-, and poly- ester derivatives of 5- methyl-2-furoic acid; di-, tri-, and poly- amide derivatives of 5-methyl-2-furoic acid; and di-, tri-, and poly- thioester derivatives of 5-methyl-2-furoic acid from 5-(halomethyl)-2-furaldehydes. These molecules are useful as plasticizers, solvents, coalescers, an ingredient in plastisol compositions, diluents, an ingredient in adhesive compositions, compatibilizer or compounding agent, or lubricant, as well as polymer compositions containing such ester compositions.
1: Radke PW, Joner M, Joost A, Byrne RA, Hartwig S, Bayer G, Steigerwald K, Wittchow E. Vascular effects of paclitaxel following drug-eluting balloon angioplasty in a porcine coronary model: the importance of excipients. EuroIntervention. 2011 Oct 30;7(6):730-7. doi: 10.4244/EIJV7I6A116. doi: 10.1016/j.ejpb.2010.08.007. Epub 2010 Aug 26. Review.
合成参考文献
摘要:Journal of Pharmaceutical Sciences., 53(774), 1964 [] 摘要:International Polymer Science and Technology., 3(93), 1976 摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 摘要:International Journal of Toxicology 42(Suppl. 3):7S-9S, 2023 摘要:International Journal of Toxicology 21(Suppl.2):1-17, 2002