专利号:US-8269001-B2 优先权日:2005-10-05 标题 :Process for the synthesis of HMG-CoA reductase inhibitors 发明人:CASAR ZDENKO 权利人:CASAR ZDENKO; LEK PHARMACEUTICALS 摘要:A novel synthesis of statins uses Wittig reaction of a heterocyclic core of statin with a lactonized side chain already possessing needed stereochemistry. Any separation of diastereoisomers is performed early in the course of synthesis.
专利号:US-2025042860-A1 优先权日:2022-04-22 标题:Process for Chemical Synthesis of Ergothioneine and Methods of Use 发明人:ZHU YONGXIAO; YU DONGDONG; ZHU YING; ZHU XI; LIAO KYLIN 权利人:NANJING NUTRABUILDING BIO TECH CO LTD 摘要:The present invention provides a process for chemical synthesis of different optical forms of ergothioneine (e.g., L-form or D-form or any mixture thereof). Another aspect of the invention relates to a composition comprising a non-racemic mixture of L-ergothioneine and D-ergothioneine.
专利号:US-2007088174-A1 优先权日:2005-10-19 标 题 :Synthesis of phenoxyacetic acid derivatives 发明人:WINTER ERIC; REICHEL CARSTEN; GUTHEIL DIETER 权利人:BOEHRINGER INGELHEIM INT 摘要:The present invention relates to an improved process for the preparation of substituted 2-(4-carbonylmethoxy-optionally 2,5-disubstituted-phenyl)-acetaldehydes, in particular 2-(4-alkoxycarbonylmethoxy-optionally 2,5-disubstituted-phenyl)-acetaldehydes and their use in the synthesis of optionally substituted 2-[4-[2-[[-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]-amino]ethyl]-optionally 2,5-disubstituted-phenoxy]acetic acid derivatives or the salts thereof, which may be used as pharmaceutically active substances.
专利号:US-2009247781-A1 优先权日:2004-10-26 标 题:Synthesis of phenoxyacetic acid derivatives 发明人:WINTER ERIC; REICHEL CARSTEN; GUTHEIL DIETER 权利人:KISSEI PHARMACEUTICAL 摘要:The present invention relates to an improved process for the preparation of substituted 2-(4-carbonylmethoxy-optionally 2,5-disubstituted-phenyl-acetaldehydes, in particular 2-(4-alkoxycarbonylmethoxy-optionally 2,5-disubstituted-phenyl)-acetaldehydes and their use in the synthesis of optionally substituted 2-[4-[2-[[-2-hydroxy-2-(4-hydroxyphenyl)- 1 -methylethyl]-amino]ethyl]-optionally 2,5-disubstituted-phenoxy]acetic acid derivatives or the salts thereof, which may be used as pharmaceutically active substances.
专利号:WO-2024157132-A1 优先权日:2023-01-25 标 题 :Process for the preparation of an intermediate useful for the synthesis of voclosporin 发明人:ROSITANO VINCENZO; MOLINARI MARCO; SENALDI LUCA; ALLEGRINI PIETRO 权利人:INDENA SPA 摘要:The invention relates to a process for the preparation of an intermediate useful for the synthesis of voclosporin, an immunosuppressant active ingredient inhibitor of calcineurin.
专利号:US-2015266745-A1 优先权日:2012-03-28 标 题:Metal Cyanometallate Synthesis Method 发明人:SONG JIE; LU YUHAO; WANG LONG 权利人:SHARP LAB OF AMERICA INC; UNIV TEXAS 摘要:A method is provided for synthesizing metal cyanometallate (MCM). The method provides a solution of A X M1 Y (CN) Z ; where “A†is selected from a first group of metals and M1 is selected from a second group of metals. The method adds a material including M2 to the solution to form a liquid phase material that may be either a suspension or a solution. M2 is selected from the second group of metals. The method adds acid to the liquid phase material. The addition of acid to the liquid phase material decomposes the M2 material into M2-ions. Simultaneous with the addition of the acid, a precipitate of A N M1 P M2 Q (CN) R .F H 2 O is formed, where N is in a range of 1 to 2. A variation of the above-described synthesis method is also provided.
1: David R, Nowicki J, Lee J, Dean N. Penile gangrene due to calciphylaxis: a multidisciplinary approach to a complex clinical challenge. BMJ Case Rep. 2019 Dec 5;12(12). pii: e232138. doi: 10.1136/bcr-2019-232138. Epub 2019 Nov 18. doi: 10.1016/j.phrs.2019.104536. [Epub ahead of print] doi: 10.1371/journal.pone.0224767. eCollection 2019. 7: Tajalli M, Qureshi AA. Successful treatment of calcinosis cutis of fingertip in the setting of CREST syndrome with topical 20% sodium thiosulfate. JAAD Case Rep. 2019 Oct 28;5(11):988-990. doi: 10.1016/j.jdcr.2019.08.011. eCollection 2019 Nov. 8: Teves A, Blanco D, Casaretto M, Torres J, Alvarado D, Jaramillo DE. Effectiveness of different disinfection techniques of the root canal in the elimination of a multi-species biofilm. J Clin Exp Dent. 2019 Nov 1;11(11):e978-e983. doi: 10.4317/jced.56000. eCollection 2019 Nov.
合成参考文献
摘要:Compound: Thiosulfuric acid (H2S2O3), monosodium salt