CAS: 85-46-1; 1-Naphthalenesulfonyl Chloride

该化合物是一种芳香磺基氯,其特点是以环烷环替换成一种环状环状的全氟辛烷基,该化合物一般是白色到浅黄色的固体,以其强烈的电益特性而著称,使其成为有机合成中的有用的试剂,具有高度反应性,特别是对于核糖分泌物而言,可参与各种化学反应,包括囊肿和全氟辛烷磺酸;该物质功能组的特点,是它能够形成磺酰胺和在与氨和酒精发生反应时产生其他衍生物. 1-Naphthalenesulfony 氯化物也用于制作磺酰氟化物药物,并且作为染料和颜料合成中的混合剂;然而,重要的是要谨慎地处理这一化合物,因为它可能具有腐蚀性,并可能导致皮肤,眼睛和呼吸系统受到刺激.适当的安全防范措施,包括使用个人防护设备,在与该化学品合作时至关重要.

英文名称1-Naphthalenesulfonyl Chloride
中文名称1-萘磺酰氯
IUPAC名称naphthalene-1-sulfonyl chloride
其它别名1-萘磺醯氯; 1-Naphthalensulyonyl Chloride
CAS编号85-46-1
MFCD编号:MFCD00003984
EINECS号:201-609-6
FDA UNII编号:3WYX4I0SJR
分子式:C10H7ClO2S
分子量:226.6791
产品CID: 1850982
产品分类有机原料→分子砌块→芳环类化合物→萘类化合物

相似结构搜索
InChIKey: DASJFYAPNPUBGG-UHFFFAOYSA-N
InChI=1S/C10H7ClO2S/c11-14(12,13)10-7-3-5-8-4-1-2-6-9(8)10/h1-7H…
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数1.0

相似化合物

93-11-8 13827-62-8 6291-07-2

物理性质

熔点64-67°C
沸点194-195°C at 760 mmHg
闪点194-195 °C/13mm
密度1.414 g/cm3
PSA:34.14
LogP:2.7673
折射率1.643
蒸汽压0.000143 mmHg at 25 °C
溶解性Chloroform: Soluble25mg/mL, Clear To Very Slightly Hazy, Colorless To Yellow
敏感性易受潮
外观形态白色至几乎白色粉末至晶体
储存条件惰性气氛,室温
产品应用该化合物用于该化合物用于改进对含有地雷和芬醇的子代谢体的分析.

MSDS等安全信息

GHS象形图
GHS符号GHS05;
注释: Corrosion
危险类别皮肤腐蚀类别1B
严重眼损伤类别1
金属腐蚀物类别1
皮肤腐蚀类别1C
警示词Danger(危险)
危险描述H314 |造成严重皮肤灼伤和眼损伤.
H318 |造成严重眼损伤.
H290 |可能对金属造成腐蚀.
防范说明P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
危险等级8
UN编号3261.0
危险品标志C
风险等级Corrosive
包装等级Ⅱ
安全声明26-36/37/39-45-27
危险类别码34
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

130-14-3 = 85-46-1
反应条件:1.1 Reagents: Phosphorus Pentachloride
标题:Conformational Analysis And Photochemical Behavior Of Sulfoxides In The Naphtho[1,2-B]Thiopyran And Naphtho[2,1-B]Thiopyran Series
作者:Still,Ian W. J.; Et Al
参考文献:Canadian Journal Of Chemistry 日期:1981 卷标:59(2) 页码:199-209]

65227-54-5 = 85-46-1
反应条件:1.1 Reagents: Chlorosuccinimide Solvents: Acetonitrile; 2 H,Rt
标题:Facile Synthesis Of Sulfonyl Chlorides/bromides From Sulfonyl Hydrazides
作者:Chen,Rongxiang; Et Al
参考文献:Molecules 日期:2021 卷标:26(18)]

= 85-46-1
反应条件:1.1 Reagents: Chlorosulfonic Acid Solvents: Chloroform; 0 - 5 °C
标题:Synthesis,Pharmacological Activity And Comparative Qsar Modeling Of 1,5-N,N'-Substituted-2-(Substituted Naphthalenesulphonyl) Glutamamides As Possible Anticancer Agents
作者:Halder,Amit Kumar; Et Al
参考文献:European Journal Of Medicinal Chemistry 日期:2010 卷标:45(5) 页码:1760-1771]

85-47-2 = 85-46-1
反应条件:1.1 Reagents: Phosphorus Oxychloride
标题:Gas Chromatographic Analysis Of Aromatic Sulfonic Acids. The Sulfonation Of Aromatic Hydrocarbons And Related Compounds
作者:Cesarz,Kathrin; Et Al
参考文献:Journal Fuer Praktische Chemie (Leipzig) 日期:1989 卷标:331(6) 页码:1011-13]

130-14-3 = 85-46-1
反应条件:1.1 Reagents: Thionyl Chloride
标题:Synthesis Of Some Naphthalene Sulfonohydrazides And Related Compounds Of Potential Biological Activity
作者:Islam,A. M.; Et Al
参考文献:Egyptian Journal Of Chemistry 日期:1987 卷标:29(4) 页码:405-31]

130-14-3 = 85-46-1
反应条件:1.1 Reagents: Phosphorus Oxychloride; 3 H,110 - 115 °C; 115 °C -> 60 °C1.2 Reagents: Water Solvents: Toluene; 20 Min,Ph 7,20 °C
标题:Synthesis,Characterization And Antimicrobial Activity Studies Of 1- & 2-[{2-(3,4-Dimethoxyphenyl)Ethyl}Methylamino]Sulphonylnaphthalenes
作者:Dayalan,A.; Et Al
参考文献:Asian Journal Of Chemistry 日期:2008 卷标:20(2) 页码:1411-1419]

10075-72-6 = 85-46-1
反应条件:1.1 Reagents: Chlorine Solvents: Chlorobenzene,Water
标题:Process For The Preparation Of Aromatic Or Heteroaromatic Sulfonyl Halides
参考文献:World Intellectual Property Organization]

13922-41-3 = 85-46-1
反应条件:1.1 Reagents: Tripotassium Phosphate Catalysts: [2′-(Amino-Kn)[1,1′-Biphenyl]-2-Yl-Kc][2′-(Diphenylphosphino-Kp)-N2,N2,N6,N6-Tet... Solvents: Acetone; 3 Min,Rt1.2 Reagents: Chlorosulfuric Acid,Phenyl Ester; 12 H,60 °C
标题:Synthesis Of Aryl Sulfonamides Via Palladium-Catalyzed Chlorosulfonylation Of Arylboronic Acids
作者:Debergh,J. Robb; Et Al
参考文献:Journal Of The American Chemical Society 日期:2013 卷标:135(29) 页码:10638-10641]

= 85-46-1
反应条件:1.1 Reagents: Chlorosulfonic Acid
标题:Synthesis,Antimicrobial And Antioxidant Activity Of Pyrazole Based Sulfonamide Derivatives
作者:Badgujar,Jagdish R.; Et Al
参考文献:Indian Journal Of Microbiology 日期:2018 卷标:58(1) 页码:93-99]

= 85-46-1
反应条件:1.1 Reagents: Chlorosulfonic Acid Solvents: Dichloromethane; 0.5 H,0 °C; 3 H,Rt
标题:Organocatalyzed Photoredox Polymerization From Aromatic Sulfonyl Halides: Facilitating Graft From Aromatic C-H Bonds
作者:Zhao,Yucheng; Et Al
参考文献:Macromolecules (Washington 日期:2018 卷标:51(3) 页码:938-946]

90-11-9 = 85-46-1
反应条件:1.1 Reagents: Butyllithium Solvents: Diethyl Ether; 20 Min,-20 °C1.2 Reagents: Sulfuryl Chloride; 1.5 H,-20 °C -> Rt
标题:A New Method For The Synthesis Of Dinaphtho[1,2-B;2',1'-D]Thiophenes And Selenophenes
作者:Alam,Ashraful; Et Al
参考文献:Heteroatom Chemistry 日期:2007 卷标:18(3) 页码:239-248]

65902-13-8 = 85-46-1
反应条件:1.1 Reagents: Chlorosuccinimide,Hydrochloric Acid Solvents: Acetonitrile; 0 °C; 0 °C -> 20 °C; 30 Min,10 - 20 °C
标题:Synthesis,Anti-Inflammatory And Analgesic Activities Of 4-Benzenesulfonyl-2(3H)-Benzoxazolone Derivatives
作者:Ma,Wen-Hua; Et Al
参考文献:Zhongguo Yaowu Huaxue Zazhi 日期:2013 卷标:23(5) 页码:358-362]

85-47-2 = 85-46-1
反应条件:1.1 Catalysts: Sodium Carbonate2.1 Reagents: Phosphorus Pentachloride
标题:Conformational Analysis And Photochemical Behavior Of Sulfoxides In The Naphtho[1,2-B]Thiopyran And Naphtho[2,1-B]Thiopyran Series
作者:Still,Ian W. J.; Et Al
参考文献:Canadian Journal Of Chemistry 日期:1981 卷标:59(2) 页码:199-209]

19387-24-7 = 85-46-1
反应条件:1.1 4 H,260 °C2.1 Reagents: Chlorosuccinimide,Hydrochloric Acid Solvents: Acetonitrile; 0 °C; 0 °C -> 20 °C; 30 Min,10 - 20 °C
标题:Synthesis,Anti-Inflammatory And Analgesic Activities Of 4-Benzenesulfonyl-2(3H)-Benzoxazolone Derivatives
作者:Ma,Wen-Hua; Et Al
参考文献:Zhongguo Yaowu Huaxue Zazhi 日期:2013 卷标:23(5) 页码:358-362]

16420-13-6 + 90-15-3 = 85-46-1
反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Methanol; Rt; 4 H,Rt1.2 10 H,Rt2.1 4 H,260 °C3.1 Reagents: Chlorosuccinimide,Hydrochloric Acid Solvents: Acetonitrile; 0 °C; 0 °C -> 20 °C; 30 Min,10 - 20 °C
标题:Synthesis,Anti-Inflammatory And Analgesic Activities Of 4-Benzenesulfonyl-2(3H)-Benzoxazolone Derivatives
作者:Ma,Wen-Hua; Et Al
参考文献:Zhongguo Yaowu Huaxue Zazhi 日期:2013 卷标:23(5) 页码:358-362]

= 85-46-1 + 93-11-8
反应条件:1.1 Reagents: Chlorosulfonic Acid Solvents: 1,2-Dichloroethane; 50 °C; 50 °C -> 80 °C; 1 H,80 °C
标题:Preparation And Characterization Of Thiophenol Compounds
作者:Feng,Baicheng; Et Al
参考文献:Qingdao Keji Daxue Xuebao 日期:2011 卷标:32(3) 页码:252-255

1-奈硫酚置于n-氯代丁二酰亚胺,四丁基氯化铵,水体系中,用乙腈作为反应溶剂,化学反应生成 1-萘磺酰氯
参考文献:使用 N-氯代琥珀酰亚胺从硫醇中方便地一锅法合成磺酰胺和磺酰叠氮化物
标题:使用 N-氯代琥珀酰亚胺从硫醇中方便地一锅法合成磺酰胺和磺酰叠氮化物
摘要:描述了从硫醇中方便地合成磺酰胺和磺酰叠氮化物.从硫醇原位制备磺酰氯是通过用 N-氯琥珀酰亚胺 (Ncs),四丁基氯化铵和水氧化来完成的.然后使磺酰氯在同一反应容器中进一步与过量的胺或叠氮化钠反应.
DOI:10.1055/s-0030-1261232

海关参考信息

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专利信息

专利号:US-4217279-A
优先权日:1978-12-18
标题 :Synthesis of steroids
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:The synthesis of 25-hydroxycholesterol and 1Î±,25-dihydroxycholesterol in which the sterol nucleus of an ester of hyodeoxycholic acid is stabilized by protection of the 3 and 6Î±-hydroxyl groups with alkyl groups, alkyl ether groups, preferably with the 3Î²-methoxyethoxymethyl group or with the heterocyclic 2-tetrahydropyran group, then extending the chain from the carbon at the 24-position to a cyanide group at the 25-position and then subjecting the sterol so formed to a series of reactions by which it is transformed into 1Î±,25-dihydroxycholesterol or by a modified series of reactions to 25-hydroxycholesterol.

专利号:US-4937367-A
优先权日:1987-07-15
标题:Process for the preparation of intermediates for the synthesis of fosfomycin
发明人：CASTALDI GRAZIANO; GIORDANO CLAUDIO
权利人:ZAMBON SPA
摘要:A process is described for the preparation of intermediates useful in the synthesis of Fosfomycin. n More particularly, an enantioselective process is described for the preparation of derivatives of (1S,2S)-1,2-dihydroxypropyl-phosphonic acid of formula ##STR1## wherein R 2 and R 3 have the meanings reported in the specification.

专利号:US-5349067-A
优先权日:1992-04-10
标题:Method for the synthesis of quaternary ammonium salts
发明人：NAKANO SHINJI; MORIMOTO TAKAO; ENDO TAKESHI
权利人:NIPPON PAINT CO LTD
摘要:Provided is a convenient method for the synthesis of quaternary ammonium sulfonate compounds which are useful as curing catalysts for one-part thermosetting resin compositions which maintain storage stability at room temperature. The compounds are synthesized by subjecting in one step a benzyl alcohol optionally having on the benzene ring and/or the Î±-position one or more substituent groups to reaction with a corresponding tertiary amine and an organic sulfonic acid chloride.

专利号:US-5663342-A
优先权日:1994-03-08
标题 :2-chloro and 2-bromo derivatives of 1,5-iminosugars
发明人：BARTA THOMAS E; MUELLER RICHARD A
权利人:SEARLE & CO
摘要:Novel 2-chloro and 2-bromo derivatives of 1,5-iminosugars are disclosed, especially such derivatives of 1,5-dideoxy-1,5-imino-D-glucitol. These compounds are useful inhibitors of glucosidase enzymes and also are useful as antiviral agents and as intermediates for the synthesis of other enzyme inhibitors and antiviral compounds.

专利号:WO-9958474-A9
优先权日:1998-05-12
标题 :Generation of combinatorial libraries of compounds corresponding to virtual libraries of compounds
发明人：GRIFFEY RICHARD; SWAYZE ERIC
权利人:ISIS PHARMACEUTICALS INC; GRIFFEY RICHARD; SWAYZE ERIC
摘要:The present invention provides methods for the generation of virtual libraries of compounds and using these libraries to build combinatorial libraries. The virtual compounds are generated in silico. The present invention encompasses methods for tracking the addition of fragments, use of reagents, and transformations performed. Further, methods for interfacing the information necessary to generate libraries of compounds with instrumentation that conducts the actual synthesis of the compounds are provided.

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SÃ˜REN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SÃ˜RENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLÃ˜K FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim BirkebÃ¦; PEDERSEN LENE; NÃ˜RREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRÃ˜DER; NEVE SÃ˜REN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SÃ˜REN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SÃ˜RENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLÃ˜K FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim BirkebÃ¦; PEDERSEN LENE; NÃ˜RREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRÃ˜DER; NEVE SÃ˜REN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

其他信息查阅

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主要参考文献

[参考文献]: Kevin G Liu, Et Al. 1-Sulfonylindazoles As Potent And Selective 5-Ht6 Ligands. Bioorg Med Chem Lett. 2009 May 1;19(9):2413-5.

合成参考文献

摘要:Kawęcki, R., Science of Synthesis Knowledge Updates, (2018) 4, 284.
摘要:Guram, A. S.; Milne, J. E.; Tedrow, J. S.; Walker, S. D., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 111.
摘要:Zhang, M.; Su, W., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 127.
摘要:Kwiecień, H. U., Science of Synthesis: Knowledge Updates, (2024) 3, 164.

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