CAS: 139-65-1; 4,4-Thiodianiline

该化合物其结构特征为结构结构,具有两个氨基组(-NH2),附于二苯硫化物脊椎,一般在室温时是一种固体,在染料和颜料合成中,特别是在纺织业中,已知该化合物有潜在用途,在有机溶剂中表现出中等溶解性,但一般在水中溶解.氨基组的存在使该化合物成为有机合成中的一种多用途中间体,允许各种化学反应,包括混合反应.然而,必须指出,4,4欧元-二氮基硫化物与健康风险有关,包括潜在的致癌性,这需要在工业应用中谨慎处理和监管.安全数据表建议,在与该化合物合作减少接触风险时使用适当的个人保护设备.总体说,尽管该化合物具有有用的用途,但安全特征需要严格的防范措施.

结构式图片

相似化合物

101-59-7 1223-31-0 1135-14-4

上下游产品

bis(4-aminophenyl)disulfide 4-thi°Cyanatoaniline 4-amino-4'-nitrodiphenyl sulfide diphenyl sulfide 2-[(4-{4-[bis(2-hydroxyethyl)amino]phenylthio}phenyl)(2-hydroxyethyl)amino]ethan-1-ol bis-(4-furfurylidenamino-phenyl)-sulfide bis-[4-(2-carboxy-benzoylamino)-phenyl]-sulfide diphenyl sulfide

合成工艺路线路线简述

    对氯苯胺置于potassium Thioacyanate,十六烷基三甲基溴化铵,Potassium Hydroxide体系中,用 水 用作溶剂,化学反应 12.0H,以55%的收率获得4,4-二氨基二苯硫醚
    参考文献:高效且可重复使用的聚苯乙烯支撑的铜(II)催化体系,用于水中芳基卤化物对硫氰酸钾的s-芳基化反应
    标题:高效且可重复使用的聚苯乙烯支撑的铜(II)催化体系,用于水中芳基卤化物对硫氰酸钾的s-芳基化反应
    摘要:成功合成了一种廉价,高效且环保的负载在聚苯乙烯上的铜(II)催化剂,并用作异氰酸酯通过芳基卤化物硫氰酸钾的s-芳基化反应的催化剂.同样,该催化剂可以被回收并重复使用几次而其催化活性没有任何明显的降低.版权所有©2016 John Wiley&sons,Ltd.
    Doi:10.1002/aoc.3471

    海关参考信息

    专利信息


    专利号:US-4766242-A
    优先权日:1982-02-01
    标 题:Synthesis of substituted aryl sulfides
    发明人:HANSON HARRY T; SAPP JR JOHN B
    权利人:HOECHST CELANESE CORP
    摘要:Provided is a novel and effective process for the synthesis of aryl sulfides substituted with an alkanoylamino or (N-alkyl)alkanoylamino substituent. The process comprises reacting an appropriately substituted aromatic compound with a sulfur dihalide, preferably sulfur dichloride, in the presence of an alkali metal tetrafluoroborate catalyst and an ether comprising solvent.

    专利号:US-9845289-B2
    优先权日:2014-08-01
    标题 :Process for the synthesis of Dapsone and its intermediates
    发明人:BARATELLA MARCO; CASTALDI GRAZIANO; CASTALDI MARTA; GABOARDI MAURO; PALLANZA GIUSEPPE
    权利人:SEEGPHARM SA
    摘要:A process for the synthesis of Dapsone and intermediates thereof are described.

    专利号:US-5003078-A
    优先权日:1989-05-16
    标 题:Synthesis of phthalonitrile resins containing ether and imide linkages
    发明人:KELLER TEDDY M
    权利人:US NAVY
    摘要:Imide-containing phthalonitrile monomers are prepared from a phthalonitrile and an aromatic dianhydride. The monomer and a method for preparing the monomer is disclosed. These monomers are synthesized into heat resistant polymers and copolymers with aromatic ring structure incorporating imide and ether linkages. The synthesis of the high temperature thermosetting polymers and copolymers is also disclosed.

    专利号:US-5292854-A
    优先权日:1989-05-16
    标题 :Synthesis of phthalonitrile resins containing ether and imide linkages with aromatic diamine curing agent
    发明人:KELLER TEDDY M
    权利人:US ARMY
    摘要:Imide-containing phthalonitrile monomers are prepared from a phthalonitrile and an aromatic dianhydride. The monomer and a method for preparing the monomer is disclosed. These monomers are synthesized into heat resistant polymers and copolymers with aromatic ring structure incorporating imide and ether linkages. The synthesis of the high temperature thermosetting polymers and copolymers is also disclosed.

    专利号:US-2013045416-A1
    优先权日:2011-08-15
    标题 :Gold micro- and nanotubes, their synthesis and use
    发明人:SEFEROS DWIGHT S; BRIDGES COLIN; DICARMINE PAUL
    权利人:UNIV TORONTO; SEFEROS DWIGHT S; BRIDGES COLIN; DICARMINE PAUL
    摘要:Synthesis of gold microtubes and nanotubes suspendable in solution is presented. The synthesis is accomplished using an AAO template route, wherein a polymer tube is used as a sacrificial core. The synthesis produces hollow structures that consist of only gold. These nanostructures exhibit two SPR modes, which correspond to both the transverse and longitudinal modes. The mode assignment was confirmed by measuring SPR behavior as both aligned arrays and in solution. The performance of gold nanotubes as refractive index detectors was quantified and determined to be more sensitive than analogous solid nanorods prepared under identical conditions, and are among the most sensitive nanostructured plasmon sensors to date. Due to their intense and sensitive resonances in the NIR spectrum, these solution-suspendable nanoparticles have potential to be used as in vitro or in vivo sensors.

    专利号:US-6500904-B1
    优先权日:2001-11-02
    标 题:High molecular weight poly(imide)s and methods of synthesis thereof
    发明人:HAYES ROBERT F
    权利人:GEN ELECTRIC
    摘要:A method for the synthesis of high molecular weight poly(imide)s comprising coupling poly(imide) precursors having complementary functional groups and a weight average molecular weight of less than about 50,000 Daltons to form high molecular weight poly (imides)s having a weight average molecular weight greater than 50,000 Daltons.
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    主要参考文献

    [参考文献]: David R Worthen, Et Al. In Vivo Evaluation Of Diaminodiphenyls: Anticonvulsant Agents With Minimal Acute Neurotoxicity. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5012-5.
    [参考文献]: Francesca Mattioli, Et Al. Dna Fragmentation And Dna Repair Synthesis Induced In Rat And Human Thyroid Cells By Four Rat Thyroid Carcinogens. Toxicol Appl Pharmacol. 2005 Mar 1;203(2):99-105.
    [参考文献]: Ilaria Massarelli, Et Al. Development Of Qsar Models For Predicting Hepatocarcinogenic Toxicity Of Chemicals. Eur J Med Chem. 2009 Sep;44(9):3658-64.
    [参考文献]: L Pomorski, Et Al. Carcinogenic Effect Of Combined Administration Of 2,4-Diaminoanisole Sulfate, 4,4'-Thiodianiline And N,N'-Diethylthiourea In Male Wistar Rats. Neoplasma. 2002;49(4):247-50.
    [参考文献]: National Toxicology Program, Et Al. 4,4'-Thiodianiline. Rep Carcinog. 2011:12:404-5.

    合成参考文献


    摘要:Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure, Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982, -(43), 1982
    摘要:U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals., NX#01564
    摘要:Pomorski L et al; Neoplasma 49 (4): 247-50 (2002).
    摘要:Franke C et al; Chemosphere 29: 1501-14 (1994)
    摘要:
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