CAS: 3282-30-2; Pivaloyl Chloride

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CAS号1634-04-4 甲基叔丁基醚 | CAS号106-47-8 对氯苯胺 | CAS号75-98-9 三甲基乙酸 | CAS号507-20-0 氯代叔丁烷 | CAS号1493-13-6 三氟甲烷磺酸 | CAS号201230-82-2 carbon monoxide | CAS号115-11-7 2-甲基丙烯 | CAS号7719-09-7 氧氯化硫 | CAS号69151-13-9 3,3-dichloro-1,... | CAS号98-88-4 苯甲酰氯 | CAS号105019-60-1 (7-methyl-2,3-d... | CAS号101724-84-9 2-[(2,2-二甲基-1-氧... | CAS号1092119-20-4 6-新戊酰氨基吡啶-3-硼酸频哪醇酯 | CAS号1110662-40-2 2,2-dimethyl-N-... | CAS号107680-78-4 2-(2,2-dimethyl... | CAS号104478-93-5 N-(4-氨基苯基)-2,2-... | CAS号108213-04-3 2,2-dimethyl-1-... | CAS号108213-06-5 1,1'-(1-methyl-... | CAS号108213-05-4 1,1'-(1''-methy... | CAS号108213-03-2 2,2-dimethyl-1-...

三甲基乙酸置于氯化亚砜,N,N-二甲基甲酰胺体系中,用 二氯甲烷 作为反应溶剂,化学反应 2.33H,反应生成 三甲基乙酰氯
参考文献:使用 Petasis 试剂从叔酰胺中溴化烯胺:一种方便的一锅式区域选择性溴甲基酮途径
标题:使用 Petasis 试剂从叔酰胺中溴化烯胺:一种方便的一锅式区域选择性溴甲基酮途径
摘要:摘要 使用 Petasis 试剂(二甲基二茂钛)作为烯胺反应生成的关键,实现了溴甲基酮的原始一锅法合成.通过改变烷基链 R 或起始材料的氨基部分,使用几种酰胺来测试该程序的限制.使原位反应生成的烯胺在低温下与溴反应,然后水解,以极好的收率(85% 至 95%)得到溴甲基酮.简要讨论了反应的机理细节和最佳条件.本方法提供了几个优点,例如烯胺形成的区域选择性,非常好的产率,温和的反应条件和易于实验.[本文提供补充材料.去出版商'
DOI:10.1080/00397911.2013.765484

专利信息

专利号:US-12012427-B2
优先权日:2019-10-31
标 题 :Synthesis of Fmoc-protected morpholino monomers and their use in the synthesis of morpholino oligomer
发明人：SINHA SURAJIT; KUNDU JAYANTA; GHOSH UJJWAL
权利人:INDIAN ASS FOR THE CULTIVATION OF SCIENCE
摘要:Present invention relates to stable Fmoc protected Morpholino monomers and corresponding oligonucleotides (PMO) and efficient synthesis of the same involving chlorophosphoramidate and H-Phosphonate chemistry. Successful syntheses of the oligonucleotide with higher yield and lesser time have been accomplished employing solid phase synthesis and easy deprotection of Fmoc group with Piperidine.

专利号:US-5760237-A
优先权日:1995-08-25
标 题 :Synthesis of l-azatyrosine using pseudoephedrine as a chiral auxiliary
发明人：MYERS ANDREW G
权利人:CALIFORNIA INST OF TECHN
摘要:A practical synthesis of the potential chemotherapeutic agent L-azatyrosine is described. The key step involved the alkylation of (R,R)-(-)-pseudoephedrine glycinamide with 5-benzenesulfonyloxy-2-iodomethylpyridine and proceeded in 70-95% yield and 89-95% de. Simultaneous hydrolysis of the auxiliary and the benzenesulfonate protecting group afforded L-azatyrosine of ≧99% ee in 73% yield on multigram scale (recovery yield of (R,R)-(-)-pseudoephedrine: 90%).

专利号:US-7160517-B2
优先权日:2000-08-18
标题 :Apparatus and methods for the automated synthesis of oligosaccharides
发明人：SEEBERGER PETER H; PLANTE OBADIAH J
权利人:MASSACHUSETTS INST OF TECHNOLG
摘要:One aspect of the present invention relates to an apparatus for the efficient synthesis of oligosaccharides on a solid support, e.g., formed by subunit addition to terminal subunits immobilized on solid-phase particles. In certain embodiments, the apparatus of the present invention is used in combinatorial methods, e.g., as described herein, of synthesizing oligosaccharides.

专利号:US-11873305-B2
优先权日:2020-06-30
标题 :Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds
发明人：ZHANG HAIMING; XU JIE; WUITSCHIK GEORG; ANGELAUD REMY; HEROLD SEBASTIAN; STUTZ ALFRED; BRUETSCH TOBIAS; BURKHARD JOHANNES
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are processes for the preparation of indolyl intermediates using Wenker Synthesis for the total synthesis of SERD compounds useful in the treatment of cancer.

专利号:WO-2024181781-A1
优先权日:2023-02-27
标 题:Substrate for synthesis of biological polymers having anti-aggregation function and biological polymer synthesis method using same
发明人：JANG MYOUNG HOON; CHOI JAE SUN
权利人:SP2 TX INC
摘要:The present invention relates to a substrate for the synthesis of biological polymers having an anti-aggregation function, and a biological polymer synthesis method using the substrate. The substrate according to an aspect may have anti-aggregation functionality to enable high-yield and high-purity processes in the synthesis of biological polymers.

专利号:WO-2009104605-A1
优先权日:2008-02-18
标 题 :Novel intermediate for synthesis of ascofranone having various physiological activities, and novel shortened total synthesis method for ascofranone using the same
发明人：SAIMOTO HIROYUKI; HAGA YASUSHI
权利人:ARIGEN PHARMACEUTICALS INC; SAIMOTO HIROYUKI; HAGA YASUSHI
摘要:In the synthesis of ascofranone, a compound represented by formula (III), (IV), (V) or (VII) or an optical isomer thereof is used as an intermediate for the synthesis. [In the formulae, R 1 and R 2 independently represent a hydrogen atom, a C 1-7 alkyl group, a phenoxyalkyl group having a halogen atom on a carbon atom in a benzene ring therein, or a phenyl group having a C 1-7 alkoxy group or a C 1-7 alkoxycarbonyl group on a carbon atom in a benzene ring therein; and X represents a halogen atom or a group R 5 SO 3 (wherein R 5 represents a C 1-7 alkyl group or a phenyl group having a C 1-7 alkyl group on a carbon atom in a benzene ring therein).] By using the compound, it becomes possible to reduce the number of steps required for the total synthesis of ascofranone to 7 or 8 from 12 which is a number of the steps required for the conventional ascofranone total synthesis processes.