CAS: 40951-39-1; 4-Aminopiperidine-4-Carboxylic Acid

相似化合物

183673-66-7 183673-71-4 288154-16-5

专利信息

专利号:US-10087221-B2
优先权日:2013-03-21
标题 :Synthesis of hydantoin containing peptide products
发明人：HENKEL BERND
权利人:SANOFI AVENTIS DEUTSCHLAND
摘要:The present invention relates to a method of synthesizing a peptide product comprising at least one hydantoin group. The peptide product may be used as a reference material for the quality control of pharmaceutical peptides, particularly for the quality control of exendin peptides. Further, the invention relates to hydantoin building blocks, a method for manufacturing such building blocks and their use for the synthesis of peptide products.

专利号:US-5880295-A
优先权日:1994-02-16
标 题 :Process for the preparation of diamine intermediates useful in the synthesis of HIV protease inhibitors
发明人：KALTENBACH III ROBERT FRANK
权利人:DU PONT PHARM CO
摘要:The present invention provides a process for the preparation of compounds of formula (V) below, and analogs thereof, which are useful as intermediates for the synthesis of HIV protease inhibitors, including cyclic ureas. ##STR1##

专利号:US-6022977-A
优先权日:1997-03-26
标 题 :Dynamic resolution of isoxazoline thioesters to isoxazoline carboxylic acids
发明人：ZHANG LIN-HUA; ANZALONE LUIGI; PESTI JAAN A; YIN JIANGUO
权利人:DU PONT PHARM CO
摘要:The present invention relates generally to a novel method for preparation of substituted isoxazolin-5-yl acetic acid in high optical purity from a stereoisomeric mixture of an esterified substituted isoxazolin-5-yl acetate. The products are useful in the synthesis of compounds for pharmaceuticals, especially the treatment of thrombolytic disorders, and agricultural products.

专利号:US-5530124-A
优先权日:1994-06-30
标 题:Method for preparing cyclic ureas and their use for the synthesis of HIV protease inhibitors
发明人：RADESCA LILIAN A; HARRIS GREGORY D; WAT EDWARD K W; WALTERMIRE ROBERT E
权利人:DU PONT MERCK PHARMA
摘要:This invention provides improved synthetic processes for the preparation of hydroxy-protected cyclic urea compounds of Formula (IX), ##STR1## which are useful as intermediates for the preparation of cyclic urea human immunodeficiency virus (HIV) protease inhibitors, from N-protected aminoaldehydes. The processes of the present invention provide high yields, can be conducted on multikilogram scale, and eliminate the need for chromatographic purification of intermediates or final product.

专利号:WO-2024146948-A1
优先权日:2023-01-05
标题:Peptide synthesis method involving sterically hindered tri-tert-butyl-tryptophan (tbt) residue
发明人：EKSTEEN JACOBUS JOHANNES; SVENDSEN JOHN SIGURD; MALMEDY FLORENCE; GUEVARA JONATHAN
权利人:AMICOAT AS
摘要:The invention is directed to a method of peptide synthesis comprising reacting a compound of Formula (I) or a salt thereof with a carbodiimide reagent to form an O-acylisourea intermediate; reacting the O-acylisourea intermediate with an additive to form an activated ester; and reacting the activated ester with an amino-containing moiety which is an amino acid, a peptide or a salt thereof comprising an amino group, wherein the amino group forms an amide bond with the carbonyl marked * in Formula (I); wherein the compound of Formula (I) has the structure: and wherein R1 and R2 are as defined in the disclosure. The invention is also directed to a compound of Formula (III) as defined in the disclosure or a salt thereof.

专利号:WO-0043352-A1
优先权日:1999-01-22
标题:A method for the synthesis of compounds of formula 1 and derivatives thereof