CAS: 611-95-0; 4-Benzoylbenzoic Acid

该化合物是含有分子式C14H10O3的白色晶状固体,主要用作有机合成的中间体,特别是用于生产紫外线可涂料和墨水的光导剂,该化合物既具有苯并基,又具有盒状酸功能组,在凝聚和蒸发反应中具有多功能性.其高纯度和稳定性使它适合在聚合物化学和制药中精确应用. 4-苯并基苯甲酸在水中表现出低溶性,但很容易溶于乙醇和丙酮等有机溶剂中,其一贯性能和特性保证了工业和研究环境中的可靠性.

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CAS号124-38-9 二氧化碳 | CAS号134-84-9 4-甲基二苯甲酮 | CAS号90-90-4 4-溴二苯甲酮 | CAS号6136-66-9 4-碘二苯酮 | CAS号619-58-9 对碘苯甲酸 | CAS号98-88-4 苯甲酰氯 | CAS号7377-26-6 4-氯甲酰基苯甲酸甲酯 | CAS号108418-27-5 2-(4-benzoylben... | CAS号91990-88-4 4-苯甲酰苯甲酸-N-琥珀酰亚胺酯 | CAS号19672-49-2 4-(二苯羟甲基)苯甲酸 | CAS号63648-38-4 4-异氰酸基二苯甲酮 | CAS号6136-67-0 3-乙氧基二苯甲酮 | CAS号620-86-0 4-(苯基甲基)苯甲酸 | CAS号164168-40-5 (2,5-dioxopyrro... | CAS号178803-51-5 4-[(S)-[(2S,5R)... | CAS号15165-27-2 4-CARBOETHOXYBE... | CAS号26077-80-5 (4-Benzoylpheny...

合成工艺路线路线简述

    苄基甲苯置于potassium Dichromate,硫酸,水体系中,化学反应生成 4-苯甲酰苯甲酸
    参考文献:Zincke,Justus Liebigs Annalen Der Chemie,1872,Vol. 161,P. 93
    标题:Zincke,Justus Liebigs Annalen Der Chemie,1872,Vol. 161,P. 93

    海关参考信息

    专利信息


    专利号:US-6531591-B1
    优先权日:1999-07-07
    标 题 :Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates
    发明人:FENSHOLDT JEF
    权利人:EXIQON AS
    摘要:Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-oligonucleotide conjugates. These phosphoramidite reagents are stable, suitable for large-scale synthesis and designed for automated solid phase synthesis of oligomers terminating in a photoreactive moiety.

    专利号:EP-1202998-B1
    优先权日:1999-07-07
    标 题 :Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates
    发明人:FENSHOLDT JEF
    权利人:EXIQON AS
    摘要:Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-oligonucleotide conjugates. These phosphoramidite reagents are stable, suitable for large-scale synthesis and designed for automated solid phase synthesis of oligomers terminating in a photoreactive moiety.

    专利号:US-6410643-B1
    优先权日:2000-03-09
    标题 :Solid phase synthesis method and reagent
    发明人:SWANSON MELVIN J
    权利人:SURMODICS INC
    摘要:A reagent composition adapted to be coated onto a support surface in order to provide that surface with a high density of reactive groups. The surface, thus coated, can be used for any suitable purpose, and is particularly well suited for use as a solid phase synthesis support surface. The synthesis support surface, in turn, can be used in repetitive and combinatorial syntheses such as the synthesis of polynucleotides, polypeptides and polysaccharides. The polymeric coating can be used to provide increased effective surface area, particularly in situations in which the effective area of the support surface is itself limited, as on the surface of a silicon wafer. In so doing, the polymeric coating provides an optimal combination of such properties as reactive density and surface area or volume.

    专利号:US-12251674-B2
    优先权日:2012-11-14
    标 题:Substrates, systems, and methods for array synthesis and biomolecular analysis
    发明人:RAJASEKARAN JOHN J; JAYARAMAN VASANTH; WANG TIANHAO; BEI KANG; KRISHNAMURTHY HARI KRISHNAN; VEDANTHAM PUNITHA
    权利人:VIBRANT HOLDINGS LLC
    摘要:Disclosed herein are formulations, substrates, and arrays. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays, including porous arrays. Also disclosed herein are formulations and methods for one-step coupling, e.g., for synthesis of peptides in an N→C orientation. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.

    专利号:US-6180830-B1
    优先权日:1995-11-08
    标题 :Method for preparing a bimetallic ruthenium/tin catalyst and a process for the synthesis of aldehydes
    发明人:JACQUOT ROLAND
    权利人:RHODIA CHIMIE SA
    摘要:The present invention relates to a new process for the preparation of a bimetallic ruthenium/tin catalyst. The process for the preparation of a bimetallic ruthenium/tin catalyst according to the invention is characterised by the fact that it consists in carrying out the reduction of a ruthenium complex having an electrovalency of -4 and a coordination number of 6, the ligands being either a halogen atom or an anion or a tin halide. The catalyst is further employed for the preparation of aldehydes by reduction, in the vapor phase, of carboxylic acids, esters and anhydrides.

    专利号:US-6069245-A
    优先权日:1996-04-17
    标 题:Asymmetric synthesis of azepines
    发明人:MATZINGER PETER KARL; SCALONE MICHELANGELO; ZUTTER ULRICH
    权利人:HOFFMANN LA ROCHE
    摘要:A novel process for the manufacture of compounds of the formula ##STR1## wherein R 1 and R 2 independently represent aroyl. The present invention also concerns novel intermediates used in the novel process for making compounds of formula I.
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    主要参考文献

    [参考文献]: G Scholz, Et Al. Brain Pyridoxal Kinase: Photoaffinity Labeling Of The Substrate-Binding Site. J Biol Chem. 1989 Mar 15;264(8):4318-21.
    [参考文献]: Jannis Wenk, Et Al. Photosensitizing And Inhibitory Effects Of Ozonated Dissolved Organic Matter On Triplet-Induced Contaminant Transformation. Environ Sci Technol. 2015 Jul 21;49(14):8541-9.
    [参考文献]: K M Defife, Et Al. Effects Of Photochemically Immobilized Polymer Coatings On Protein Adsorption, Cell Adhesion, And The Foreign Body Reaction To Silicone Rubber. J Biomed Mater Res. 1999 Mar 5;44(3):298-307.
    [参考文献]: K M Defife, Et Al. Photochemically Immobilized Polymer Coatings: Effects On Protein Adsorption, Cell Adhesion, And Leukocyte Activation. J Biomater Sci Polym Ed. 1999;10(10):1063-74.
    [参考文献]: Randy M Wadkins, Et Al. Identification And Characterization Of Novel Benzil (Diphenylethane-1,2-Dione) Analogues As Inhibitors Of Mammalian Carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15.

    合成参考文献


    摘要:Wicha, J., Science of Synthesis, (2009) 48, 110.
    摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2018) 3, 134.
    摘要:González-Bello, C., Science of Synthesis Knowledge Updates, (2018) 1, 215.
    摘要:Takaya, J.; Iwasawa, N., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 2, 283.
    摘要:Yi, C. S., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 230.
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