CAS: 622-08-2; 2-(Benzyloxy)Ethanol

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CAS号100-39-0 溴化苄 | CAS号107-21-1 乙二醇 | CAS号100-44-7 氯化苄 | CAS号936-51-6 2-苯基-1,3-二四氢呋喃 | CAS号60656-87-3 苄氧基乙醛 | CAS号31600-43-8 苄氧乙酸甲酯 | CAS号96-49-1 碳酸乙烯酯 | CAS号106-44-5 对甲酚 | CAS号122-99-6 乙二醇苯醚 | CAS号38336-04-8 2-苄基-1-乙胺 | CAS号420137-14-0 3-苯甲氧基吡咯烷 | CAS号936-51-6 2-苯基-1,3-二四氢呋喃 | CAS号23043-24-5 p-Toluidine, al... | CAS号2050-25-1 二(乙二醇)苯甲醚 | CAS号107-21-1 乙二醇 | CAS号82166-21-0 2-methyl cyclohexane | CAS号1462-37-9 苄基-2-溴乙基醚 | CAS号100-39-0 溴化苄 | CAS号86259-87-2 四甘醇单苄醚

苄氧基乙醛置于a-无水葡萄糖酯,Dichloro(Pentamethylcyclopentadienyl)Rhodium (Iii) Dimer,Sodium Acetate体系中,用 1,2-二氯乙烷 作为反应溶剂,化学反应 24.0H,以75%的收率获得产物2-苄氧基乙醇
参考文献:以生物质为氢源的催化转移加氢
标题:以生物质为氢源的催化转移加氢
摘要:我们开发了一种操作简单的方法,可在基本重要的过程(例如加氢)中直接使用生物质衍生的化学实体.各种碳水化合物,淀粉和木质素用于立体选择性氢化.利用过渡金属催化剂和新颖的催化体系,证明了炔烃,烯烃和羰基的高产率还原.通过简单改变反应条件来建立区域选择性氢化以得到不同的立体异构体.这项工作基于前所未有的催化系统,代表了生物质作为还原剂在化学反应中的直接应用.
DOI:10.1002/cssc.201801770

专利信息

专利号:US-2013267680-A1
优先权日:2010-09-15
标题:Total chemical synthesis of ubiquitin, ubiquitin mutants and derivatives thereof
发明人：OVAA HUIB; EL OUALID FARID; MERKX REMCO NICOLAAS SEBASTIAAN MICHEL
权利人:OVAA HUIB; EL OUALID FARID; MERKX REMCO NICOLAAS SEBASTIAAN MICHEL; STICHTING HET NL KANKERINST
摘要:The present invention relates to the field of total chemical synthesis of ubiquitin and related peptides. More in particular, a method is provided of solid phase synthesis of ubiquitin, ubiquitin mutants and derivatives thereof. It was the object of the present invention to provide an approach for the total chemical synthesis of ubuiqitin, which allows for the chemical synthesis of virtually any Ub mutant and giving high overall efficiency and purity. The present inventors have surprisingly found that this object can be realized with a method relying on incorporation of special amino acid building blocks. This approach was found to allow for exceptionally high yields of up to 14% and to provide an synthetic entry into virtually any ubiquitin derivative.

专利号:EP-2607355-A1
优先权日:2011-12-23
标 题:Synthesis of triazolopyrimidine compounds
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.

专利号:EP-2666771-A1
优先权日:2012-05-24
标题 :Synthesis of Aminocyclopentanetriol Derivatives
发明人：STERK DAMJAN; CASAR ZDENKO
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor. nThe present invention provides in particular a process for the preparation of a compound of formula Vn ncomprising: na) providing a compound of formula IVn n, and nb) reducing the compound of formula IV with activated zinc in the presence of copper to give the compound of formula V.

专利号:US-9278972-B2
优先权日:2011-12-23
标题 :Synthesis of triazolopyrimidine compounds
发明人：MARAS NENAD; GAZIC SMILOVIC IVANA; STERK DAMJAN
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.

专利号:US-7244753-B2
优先权日:2002-07-29
标 题:Cyclooxygenase-2 selective inhibitors, compositions and methods of use
发明人：GARVEY DAVID S; KHANAPURE SUBHASH P; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D
权利人:NITROMED INC
摘要:The invention describes novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one COX-2 selective inhibitor, optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor, and/or, optionally, at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention can be optionally nitrosated and/or nitrosylated. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal and/or respiratory toxicity; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.

专利号:US-2005209355-A1
优先权日:2004-03-22
标 题:[Novel Reactions and the Products of Such Reactions]
发明人：ROITMAN LIPA L
权利人:ROITMAN LIPA L
摘要:A process for the synthesis of novel compounds is described comprising reacting tetrachloroethylene with substances containing active methylene group in the presence of free radical initiators. Also, a process for grafting tetrachloroethylene is described comprising reacting these compounds with polymers containing active methylene group in the presence of free radical initiators. Furthermore, a method of conducting such reactions to high conversion is described, comprising conducting the reactions in the reflux condensate. The present invention provides a novel and high yield route for heretofore unobtainable materials.